Inhibition of Mammalian Target of Rapamycin Attenuates Recurrent Seizures Associated Cardiac Damage in a Zebrafish Kindling Model of Chronic Epilepsy

The Epileptic Heart: Concept and clinical evidence

(2020) Richard L. Verrier et al.   EPILEPSY & BEHAVIOR

Deciphering key regulators involved in epilepsy‐induced cardiac damage through whole transcriptome and proteome analysis in a rat model

(2020) Supriya Sharma et al.   EPILEPSIA

Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents

(2020) Savita Kumari et al.   JOURNAL OF NEUROSCIENCE METHODS

Update on the Genetic Basis of Sudden Unexpected Death in Epilepsy

(2019) Monica Coll et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva

(2019) Savita Kumari et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Spontaneous recurrent seizures mediated cardiac dysfunction via mTOR pathway upregulation: A putative target for SUDEP management

(2019) Supriya Sharma et al.   CNS & Neurological Disorders-Drug Targets

Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures

(2019) Garima Tanwar et al.   Scientific Reports

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds

(2019) Christina M. Hull et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Use of Zebrafish in Drug Discovery Toxicology

(2019) Steven Cassar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rapamycin regulates the balance between�cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling

(2019) Guangyuan Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus

(2018) Pallavi Sharma et al.   NUTRITIONAL NEUROSCIENCE

Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy

(2018) Arindam Ghosh Mazumder et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular and Genetic Aspects of Guanylyl Cyclase Natriuretic Peptide Receptor-A in Regulation of Blood Pressure and Renal Function

(2018) Kailash N. Pandey   PHYSIOLOGICAL GENOMICS

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies

(2018) Daniel J Beard et al.   International Journal of Stroke

SCN5A Variants: Association With Cardiac Disorders

(2018) Wenjia Li et al.   Frontiers in Physiology

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapamycin alleviates oxidative stress-induced damage in rat erythrocytes

(2016) Abhishek Kumar Singh et al.   Biochemistry and Cell Biology

Anticancer Mammalian Target of Rapamycin (mTOR) Signaling Pathway Inhibitors: Current Status, Challenges and Future Prospects in Management of Epilepsy

(2016) Arindam Ghosh Mazumder et al.   CNS & Neurological Disorders-Drug Targets

B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced SurvivalNovelty and Significance

(2015) Sara J. Holditch et al.   HYPERTENSION

Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish

(2015) Anna Maria Siebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia

(2015) Pablo Calap-Quintana et al.   PLoS One

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

(2015) Masataka Ikeda et al.   Scientific Reports

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins

(2014) Cristina S. Mesquita et al.   ANALYTICAL BIOCHEMISTRY

Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins

(2014) Kentaro Hirose et al.   BMC DEVELOPMENTAL BIOLOGY

Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention

(2014) Cory A. Massey et al.   Nature Reviews Neurology

Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice

(2014) ZHEN HE et al.   ONCOLOGY REPORTS

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Augmented Cardiac Formation of Oxidatively-Induced Carbonylated Proteins Accompanies the Increased Functional Severity of Post-Myocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus

(2013) Kathleen E. Dennis et al.   CARDIOVASCULAR PATHOLOGY

Seizures Induced by Pentylenetetrazole in the Adult Zebrafish: A Detailed Behavioral Characterization

(2013) Ben Hur M. Mussulini et al.   PLoS One

Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade

(2013) Kalkidan Bishu et al.   PLoS One

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1

(2013) M. Volkers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

(2013) W. E. Parker et al.   Science Translational Medicine

Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy

(2012) Robin C. C. Ryther et al.   Current Neurology and Neuroscience Reports

Epilepsy in poor regions of the world

(2012) Charles R Newton et al.   LANCET

The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice

(2012) Adam L. Hartman et al.   PLoS One

Specific antioxidant selenoproteins are induced in the heart during hypertrophy

(2011) FuKun W. Hoffmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

(2011) Ruomin Di et al.   BIOCHEMICAL JOURNAL

Perspectives of zebrafish models of epilepsy: What, how and where next?

(2011) Adam Michael Stewart et al.   BRAIN RESEARCH BULLETIN

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells

(2011) B. W. Luikart et al.   JOURNAL OF NEUROSCIENCE

Oxidation of Myofibrillar Proteins in Human Heart Failure

(2011) Marcella Canton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac oxidative stress is involved in heart failure induced by thiamine deprivation in rats

(2010) Carolina Rosa Gioda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Potential Relevance of Bell-Shaped and U-Shaped Dose-Responses for the Therapeutic Targeting of Angiogenesis in Cancer

(2010) Andrew R. Reynolds   Dose-Response

Autonomic alterations and cardiac changes in epilepsy

(2010) Cristian Sevcencu et al.   EPILEPSIA

Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model

(2010) Yukihiro Ohno et al.   EPILEPSY RESEARCH

Beneficial Effects of Mammalian Target of Rapamycin Inhibition on Left Ventricular Remodeling After Myocardial Infarction

(2009) Sebastian J. Buss et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

(2008) Anthony J. Muslin   CLINICAL SCIENCE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY