Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds

Zebrafish as a model of mammalian cardiac function: Optically mapping the interplay of temperature and rate on voltage and calcium dynamics

(2018) Kaveh Rayani et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

(2018) Chantal J.M. van Opbergen et al.   Theranostics

Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation

(2015) Eric Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Zebrafish heart as a model for human cardiac electrophysiology

(2015) Matti Vornanen et al.   Channels

Stoichiometry of altered hERG1 channel gating by small molecule activators

(2014) Wei Wu et al.   JOURNAL OF GENERAL PHYSIOLOGY

An In Vivo Cardiac Assay to Determine the Functional Consequences of Putative Long QT Syndrome Mutations

(2013) Chuanchau J. Jou et al.   CIRCULATION RESEARCH

HERG1 channel agonists and cardiac arrhythmia

(2013) Michael C Sanguinetti   CURRENT OPINION IN PHARMACOLOGY

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

(2013) Yen May Cheng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin

(2013) Haiyan Mao et al.   PLoS One

Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation

(2013) Girish Hari Chaudhari et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Enhanced Repolarization Capacity: New Potential Antiarrhythmic Strategy Based on hERG Channel Activation

(2011) G. Szabo et al.   CURRENT MEDICINAL CHEMISTRY

Zebrafish as a model for long QT syndrome: the evidence and the means of manipulating zebrafish gene expression

(2010) I. U. S. Leong et al.   Acta Physiologica

Calcium handling in zebrafish ventricular myocytes

(2010) Ping-Cheng Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Identification and expression analysis of kcnh2 genes in the zebrafish

(2010) Ivone Un San Leong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

(2010) David S. Peal et al.   CIRCULATION

Congenital long QT syndrome and 2:1 atrioventricular block: An optimistic outcome in the current era

(2010) Peter F. Aziz et al.   HEART RHYTHM

Molecular Determinants of Human ether-a-go-go-Related Gene 1 (hERG1) K+ Channel Activation by NS1643

(2010) M. Grunnet et al.   MOLECULAR PHARMACOLOGY

Biophysical properties of zebrafish ether-à-go-go related gene potassium channels

(2009) Eberhard P. Scholz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

(2009) David J. Milan et al.   CIRCULATION

Adult zebrafish heart as a model for human heart? An electrophysiological study

(2009) Petros Nemtsas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

(2009) M. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio)

(2008) Fabien Brette et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

(2008) H R Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome

(2008) Thomas G. Diness et al.   CARDIOVASCULAR RESEARCH

Deficient Zebrafish Ether-à-Go-Go –Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants

(2008) David Hassel et al.   CIRCULATION

Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome

(2008) Chinmay Patel et al.   HEART RHYTHM

Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

(2008) X. Xu et al.   MOLECULAR PHARMACOLOGY

Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart

(2007) M. J. Killeen et al.   Acta Physiologica

A Single Amino Acid Difference between Ether-a-go-go- Related Gene Channel Subtypes Determines Differential Sensitivity to a Small Molecule Activator

(2007) M. Perry et al.   MOLECULAR PHARMACOLOGY