Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation

Isatin dimers and their biological activities

(2020) Ya‐Zhou Zhang et al.   ARCHIV DER PHARMAZIE

Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors

(2020) Mohamed A. Salem et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular docking study based on novel fused pyrazolothiazole scaffold

(2020) Hala F. Rizk et al.   Journal of the Iranian Chemical Society

Modulation of chloroplast components and defense responses during programmed cell death in tobacco infected with Pseudomonas syringae

(2020) Bao Quoc Tran et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies

(2020) Yousry A. Ammar et al.   BIOORGANIC CHEMISTRY

In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies

(2020) Eman A. Fayed et al.   BIOORGANIC CHEMISTRY

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity

(2020) Ashraf S. Hassan et al.   MOLECULES

The importance of indole and azaindole scaffold in the development of antitumor agents

(2020) Yu Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors

(2020) Mohammed M.S. Wassel et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers

(2019) Ahmed M. Sh. El-Sharief et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents

(2019) Eman A. Fayed et al.   MEDICINAL CHEMISTRY RESEARCH

Caspase-3 mediated programmed cell death by a gold-stabilised peptide carbene

(2019) Astha Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules

(2019) Hesham A. Abou-Zied et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line

(2019) Mina Hanifeh Ahagh et al.   BIOORGANIC CHEMISTRY

One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor

(2019) Mohamed A. Salem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

(2018) Dhiraj Kumar et al.   BMC CANCER

The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats

(2018) Arzu Keskin-Aktan et al.   BRAIN RESEARCH BULLETIN

Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity

(2018) Yousry A. Ammar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents

(2018) Eman A. Fayed et al.   MOLECULAR DIVERSITY

Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS

(2017) Stephen J. Capuzzi et al.   Journal of Chemical Information and Modeling

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

(2017) et al.   MOLECULES

New chalcones bearing isatin scaffold: synthesis, molecular modeling and biological evaluation as anticancer agents

(2017) Yousry A. Ammar et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Preclinical evaluation and molecular docking of 1,3-benzodioxole propargyl ether derivatives as novel inhibitor for combating the histone deacetylase enzyme in cancer

(2017) Neeraj Kumar et al.   Artificial Cells Nanomedicine and Biotechnology

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities

(2016) Yousry A. Ammar et al.   CURRENT ORGANIC SYNTHESIS

Design and synthesis of isatin/triazole conjugates that induce apoptosis and inhibit migration of MGC-803 cells

(2016) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Review on EGFR Inhibitors: Critical Updates

(2016) Davinder Singh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: synthesis, reactions and evaluation of antibacterial and antifungal activities

(2016) Marwa A.M.Sh. El-Sharief et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Synthesis and evaluation of antitumour activities of novel fused tri- and tetracyclic uracil derivatives

(2016) Samar ElKalyoubi et al.   JOURNAL OF CHEMICAL RESEARCH

Mitochondrial apoptosis: killing cancer using the enemy within

(2015) J Lopez et al.   BRITISH JOURNAL OF CANCER

New small-molecule drug design strategies for fighting resistant influenza A

(2015) Zuyuan Shen et al.   Acta Pharmaceutica Sinica B

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives

(2014) Tamer Nasr et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis

(2014) B.R. Vijay Avin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus

(2014) Nisha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity

(2014) Parvaneh Pakravan et al.   Pharmacological Reports

Stoichiometry-controlled cycloaddition of azomethine ylide with dipolarophiles: chemoselective and regioselective synthesis of bis- and tris-spirooxindole derivatives

(2014) Srinu Lanka et al.   TETRAHEDRON LETTERS

Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2013) Nguyen-Hai Nam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

(2013) Chengyuan Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cellular Mechanisms Controlling Caspase Activation and Function

(2013) A. B. Parrish et al.   Cold Spring Harbor Perspectives in Biology

Role of epidermal growth factor receptor in breast cancer

(2012) Hiroko Masuda et al.   BREAST CANCER RESEARCH AND TREATMENT

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents

(2012) Nan Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis

(2012) Anwen M. Krause-Heuer et al.   MedChemComm

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Hybrid pharmacophore design and synthesis of isatin–benzothiazole analogs for their anti-breast cancer activity

(2009) V. Raja Solomon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antibacterial and antifungal activity of metal(II) complexes of acylhydrazones of 3-isatin and 3-(N-methyl)isatin

(2009) María C. Rodríguez-Argüelles et al.   POLYHEDRON

Luminescent Biological Probes Derived from Ruthenium(II) Estradiol Polypyridine Complexes

(2007) Kenneth Kam-Wing Lo et al.   INORGANIC CHEMISTRY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY