The Role of the Membrane in Transporter Folding and Activity

Activation of G-protein coupled receptors is thermodynamically linked to lipid solvation

(2021) Alison N. Leonard et al.   BIOPHYSICAL JOURNAL

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

(2021) Rahul Chadda et al.   eLife

Lipid-Protein Interactions Are a Unique Property and Defining Feature of G Protein-Coupled Receptors

(2020) Besian I. Sejdiu et al.   BIOPHYSICAL JOURNAL

Membrane mediated toppling mechanism of the folate energy coupling factor transporter

(2020) Ignacio Faustino et al.   Nature Communications

An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

(2020) Vincent Debruycker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell-free expression tools to study co-translational folding of alpha helical membrane transporters

(2020) Nicola J. Harris et al.   Scientific Reports

The structural basis of promiscuity in small multidrug resistance transporters

(2020) Ali A. Kermani et al.   Nature Communications

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

(2019) Maria E Falzone et al.   eLife

Emerging Diversity in Lipid–Protein Interactions

(2019) Valentina Corradi et al.   CHEMICAL REVIEWS

Lipid-Assisted Membrane Protein Folding and Topogenesis

(2019) William Dowhan et al.   PROTEIN JOURNAL

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

(2019) Valeria Kalienkova et al.   eLife

Local Enrichment of Unsaturated Chains around the A2A Adenosine Receptor

(2019) Lewen Yang et al.   BIOCHEMISTRY

Force-induced conformational changes in PIEZO1

(2019) Yi-Chih Lin et al.   NATURE

Dynamic membrane topology in an unassembled membrane protein

(2019) Maximilian Seurig et al.   Nature Chemical Biology

Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness

(2019) Delin Sun et al.   BIOPHYSICAL JOURNAL

Direct Derivation of Free Energies of Membrane Deformation and Other Solvent Density Variations From Enhanced Sampling Molecular Dynamics

(2019) Giacomo Fiorin et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins

(2019) George Khelashvili et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The energetics of protein–lipid interactions as viewed by molecular simulations

(2019) Robin A. Corey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Large-scale state-dependent membrane remodeling by a transporter protein

(2019) Wenchang Zhou et al.   eLife

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

(2018) Louise Laursen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers

(2018) Rahul Chadda et al.   JOURNAL OF GENERAL PHYSIOLOGY

­­Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force­

(2018) Claudio Anselmi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Unfolding of a ClC chloride transporter retains memory of its evolutionary history

(2018) Duyoung Min et al.   Nature Chemical Biology

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid bilayer composition modulates the unfolding free energy of a knotted α-helical membrane protein

(2018) M. R. Sanders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanidinium export is the primal function of SMR family transporters

(2018) Ali A. Kermani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery revealed within lipid binding events to membrane proteins

(2018) John W. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

(2018) Talia Zeppelin et al.   PLoS Computational Biology

A facile approach for the in vitro assembly of multimeric membrane transport proteins

(2018) Erika A Riederer et al.   eLife

Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins

(2018) Valentina Corradi et al.   ACS Central Science

Crystal Structure of a ligand-bound LacY–Nanobody Complex

(2018) Hemant Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

Structure and activity of lipid bilayer within a membrane-protein transporter

(2018) Weihua Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Protein–phospholipid interplay revealed with crystals of a calcium pump

(2017) Yoshiyuki Norimatsu et al.   NATURE

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(2017) David Dickens et al.   Scientific Reports

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Homeoviscous Adaptation and the Regulation of Membrane Lipids

(2016) Robert Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

The Continuing Mystery of Lipid Rafts

(2016) Ilya Levental et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insight in the toppling mechanism of an energy-coupling factor transporter

(2016) Lotteke J. Y. M. Swier et al.   Nature Communications

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

The dimerization equilibrium of a ClC Cl−/H+ antiporter in lipid bilayers

(2016) Rahul Chadda et al.   eLife

Structural Symmetry in Membrane Proteins

(2015) Lucy R. Forrest   Annual Review of Biophysics

Lipid agonism: The PIP2 paradigm of ligand-gated ion channels

(2015) Scott B. Hansen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin

(2015) Henriette Bjerregaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Monomerization of a ClC-Type Fluoride Transporter

(2015) Nicholas B. Last et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Integral Membrane Protein Insertion and Folding

(2015) Florian Cymer et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structures of a double-barrelled fluoride ion channel

(2015) Randy B. Stockbridge et al.   NATURE

Transport domain unlocking sets the uptake rate of an aspartate transporter

(2015) Nurunisa Akyuz et al.   NATURE

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

Lipid–protein interactions as determinants of membrane protein structure and function

(2015) William Dowhan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structures of bacterial homologues of SWEET transporters in two distinct conformations

(2014) Yan Xu et al.   NATURE

Structural evidence for functional lipid interactions in the betaine transporter BetP

(2013) Caroline Koshy et al.   EMBO JOURNAL

Energetics and Location of Phosphoinositide Binding in Human Kir2.1 Channels

(2013) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

(2013) Guus B. Erkens et al.   NATURE

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein

(2013) Heidi Vitrac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of cholesterol in dopamine transporter function

(2012) Kymry T. Jones et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP

(2012) Camilo Perez et al.   NATURE

The role of trimerization in the osmoregulated betaine transporter BetP

(2011) Camilo Perez et al.   EMBO REPORTS

Dramatic Destabilization of Transmembrane Helix Interactions by Features of Natural Membrane Environments

(2011) Heedeok Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

Stable folding core in the folding transition state of an  -helical integral membrane protein

(2011) P. Curnow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers

(2011) C. P. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The reconstitutedEscherichia coliMsbA protein displays lipid flippase activity

(2010) Paul D. W. Eckford et al.   BIOCHEMICAL JOURNAL

Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals

(2010) Richard K Hite et al.   EMBO JOURNAL

Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding

(2010) Weimin C. Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Specific Activation of Human Inward Rectifier K+Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, function and structure of a monomeric ClC transporter

(2010) Janice L. Robertson et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Method to measure strong protein-protein interactions in lipid bilayers using a steric trap

(2010) H. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro Unfolding and Refolding of the Small Multidrug Transporter EmrE

(2009) David Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a prokaryotic virtual proton pump at 3.2 Å resolution

(2009) Yiling Fang et al.   NATURE

Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel

(2009) Yi Wang et al.   NATURE

Protein modulation of lipids, and vice-versa, in membranes

(2008) Derek Marsh   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Association energetics of membrane spanning α-helices

(2008) K MACKENZIE et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY