Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

(2021) Cristina Olivieri et al.   Communications Biology

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

(2020) Cristina Olivieri et al.   eLife

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

(2019) Caitlin Walker et al.   Science Advances

Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA ): the expected, the unexpected, and what might be next

(2018) Constantine A Stratakis   JOURNAL OF PATHOLOGY

NMR methods to dissect the molecular mechanisms of disease-related mutations (DRMs): Understanding how DRMs remodel functional free energy landscapes

(2018) Jung Ah Byun et al.   METHODS

Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas WithoutPRKACAp.Leu206Arg Mutation

(2016) Cristina L. Ronchi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A genetic and molecular update on adrenocortical causes of Cushing syndrome

(2016) Maya Lodish et al.   Nature Reviews Endocrinology

PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia: a single-center study of 60 cases

(2015) A. Thiel et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

cAMP signaling in cortisol-producing adrenal adenoma

(2015) Davide Calebiro et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cushing's syndrome

(2015) André Lacroix et al.   LANCET

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

(2015) Zachariah H. Foda et al.   Nature Communications

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]

(2014) Yasuyo Nakajima et al.   ENDOCRINE JOURNAL

Novel Somatic Mutations in the Catalytic Subunit of the Protein Kinase A as a Cause of Adrenal Cushing's Syndrome: A European Multicentric Study

(2014) Guido Di Dalmazi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

pmx: Automated protein structure and topology generation for alchemical perturbations

(2014) Vytautas Gapsys et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

(2014) Gerald Goh et al.   NATURE GENETICS

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

(2014) Felix Beuschlein et al.   NEW ENGLAND JOURNAL OF MEDICINE

NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding

(2014) Alessandro Cembran et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Dynamic architecture of a protein kinase

(2014) C. L. McClendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome

(2014) Y. Cao et al.   SCIENCE

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome

(2014) Y. Sato et al.   SCIENCE

PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit

(2014) Davide Calebiro et al.   Nature Communications

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

(2014) Stephen Boulton et al.   Scientific Reports

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations

(2012) Alessandro Cembran et al.   BIOCHEMISTRY

xPyder: A PyMOL Plugin To Analyze Coupled Residues and Their Networks in Protein Structures.

(2012) Marco Pasi et al.   Journal of Chemical Information and Modeling

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

(2011) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface

(2010) Friedrich W. Herberg et al.   PROTEIN SCIENCE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Comparative surface geometry of the protein kinase family

(2009) Elaine E. Thompson et al.   PROTEIN SCIENCE

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Cooperativity in macromolecular assembly

(2008) James R Williamson   Nature Chemical Biology

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA