Development of Membrane-Active Honokiol/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA)

Triphenyl-sesquineolignan analogues derived from Illicium simonsii Maxim exhibit potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial membranes

(2021) Yong Guo et al.   BIOORGANIC CHEMISTRY

The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents

(2021) Christian Hobson et al.   CHEMICAL REVIEWS

Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model

(2020) Jing Li et al.   ACS Chemical Neuroscience

The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later

(2020) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Hydrophobicity-Modulated Small Antibacterial Molecule Eradicates Biofilm with Potent Efficacy against Skin Infections

(2020) Mohini Mohan Konai et al.   ACS Infectious Diseases

Antimicrobial Resistance in ESKAPE Pathogens

(2020) David M. P. De Oliveira et al.   CLINICAL MICROBIOLOGY REVIEWS

In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria

(2020) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens

(2020) Meirong Song et al.   Nature Microbiology

CT1-3, a novel magnolol-sulforaphane hybrid suppresses tumorigenesis through inducing mitochondria-mediated apoptosis and inhibiting epithelial mesenchymal transition

(2020) Cheng Tao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections

(2020) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The value of antimicrobial peptides in the age of resistance

(2020) Maria Magana et al.   LANCET INFECTIOUS DISEASES

Discovery, synthesis and biological evaluation of dunnianol-based Mannich bases against methicillin-resistant Staphylococcus aureus (MRSA)

(2020) Yong Guo et al.   ACS Infectious Diseases

Discovery of thiosemicarbazones derivatives as effective New Delhi metallo‒ ‒lactamase‒1 (NDM‒1) inhibitors against NDM‒1 producing clinical isolates

(2020) Bing Zhao et al.   Acta Pharmaceutica Sinica B

Mechanistic Landscape of Membrane-Permeabilizing Peptides

(2019) Shantanu Guha et al.   CHEMICAL REVIEWS

Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance

(2019) Chandradhish Ghosh et al.   TRENDS IN MICROBIOLOGY

Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

(2019) Jing Yan et al.   Cell Host & Microbe

Synthesis and Bioactivities of New Membrane-Active Agents with Aromatic Linker: High Selectivity and Broad-Spectrum Antibacterial Activity

(2019) Wenchao Chu et al.   ACS Infectious Diseases

A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

(2019) Cristian Ochoa et al.   ACS Infectious Diseases

Natural products as sources of new antioxidants: Synthesis and antioxidant evaluation of Mannich bases of novel sesamol derivatives

(2019) Yong Guo et al.   INDUSTRIAL CROPS AND PRODUCTS

Design, synthesis and antibacterial evaluation of honokiol derivatives

(2018) Bo Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Bioactivity of Polymer-Based Synthetic Mimics of Antimicrobial Peptides (SMAMPs) Made from Asymmetrically Disubstituted Itaconates

(2018) David Boschert et al.   CHEMISTRY-A EUROPEAN JOURNAL

OUP accepted manuscript

(2018)   CLINICAL INFECTIOUS DISEASES

Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents

(2018) Youhong Niu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Harnessing the Chemical Diversity of the Natural Product Magnolol for the Synthesis of Renewable, Degradable Neolignan Thermosets with Tunable Thermomechanical Characteristics and Antioxidant Activity

(2018) Kevin T. Wacker et al.   BIOMACROMOLECULES

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

(2017) Ma Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail

(2017) Debra A Goff et al.   LANCET INFECTIOUS DISEASES

Opportunities for natural products in 21st century antibiotic discovery

(2017) Gerard D. Wright   NATURAL PRODUCT REPORTS

The drug-resistant bacteria that pose the greatest health threats

(2017) Cassandra Willyard   NATURE

Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli

(2017) Guo-Biao Zhang et al.   Science China-Chemistry

Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria

(2017) Amy E. Solinski et al.   ACS Infectious Diseases

Activity of Fusidic Acid Tested against Staphylococci Isolated from Patients in U.S. Medical Centers in 2014

(2016) David J. Farrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitroantimicrobial activity of honokiol againstStaphylococcus aureusin biofilm mode

(2016) Wen-Li Li et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-Infective

(2016) Regis P. Kowalski et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Natural Products as a Source for Novel Antibiotics

(2016) Mark G. Moloney   TRENDS IN PHARMACOLOGICAL SCIENCES

The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)

(2015) Eun-Jin Choi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus

(2015) Megan C. Jennings et al.   ACS Infectious Diseases

Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16

(2014) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Designing Mimics of Membrane Active Proteins

(2013) Federica Sgolastra et al.   ACCOUNTS OF CHEMICAL RESEARCH

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultrashort Peptide Bioconjugates Are Exclusively Antifungal Agents and Synergize with Cyclodextrin and Amphotericin B

(2011) Christopher J. Arnusch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption

(2011) Johan Isaksson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A miniature mimic of host defense peptides with systemic antibacterial efficacy

(2010) Hadar Sarig et al.   FASEB JOURNAL

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA