Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy

TLR2 Agonistic Small Molecules: Detailed Structure–Activity Relationship, Applications, and Future Prospects

(2020) Arshpreet Kaur et al.   JOURNAL OF MEDICINAL CHEMISTRY

TLR1/2 Specific Small‐Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes

(2019) Xiaohong Cen et al.   Advanced Science

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

(2019) Lijing Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors

(2019) Zhipeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer

(2018) Si-si Wang et al.   Cellular & Molecular Immunology

Structure-based discovery of a specific TLR1–TLR2 small molecule agonist from the ZINC drug library database

(2018) Zhipeng Chen et al.   CHEMICAL COMMUNICATIONS

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

(2018) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

(2018) Matthew D. Morin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine–Quinolone Carboxamides

(2018) Ziwei Hu et al.   ACS Medicinal Chemistry Letters

Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

(2018) Gijs G. Zom et al.   Journal for ImmunoTherapy of Cancer

Naive CD4+T Cells Carrying a TLR2 Agonist Overcome TGF-β–Mediated Tumor Immune Evasion

(2017) Mohsen Ibrahim et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

(2017) Hiroaki Shime et al.   OncoImmunology

Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia

(2015) Nina Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

(2015) Mark A. Olson et al.   Scientific Reports

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

(2015) Melissa Santone et al.   Human Vaccines & Immunotherapeutics

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

(2015) K. Cheng et al.   Science Advances

Synergistic Anticancer Effects of Pam3CSK4 and Ara-C on B-Cell Lymphoma Cells

(2014) S.-K. Lee et al.   CLINICAL CANCER RESEARCH

Systemic injection of TLR1/2 agonist improves adoptive antigen-specific T cell therapy in glioma-bearing mice

(2014) Yufei Zhang et al.   CLINICAL IMMUNOLOGY

The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses

(2014) Brendon Y Chua et al.   IMMUNOLOGY AND CELL BIOLOGY

Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines

(2014) Mallesh Beesu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand-Peptide Conjugates

(2014) G. G. Zom et al.   Cancer Immunology Research

Targeting Toll-like receptors with small molecule agents

(2013) Xiaohui Wang et al.   CHEMICAL SOCIETY REVIEWS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex

(2012) Kui Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation and Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory Agents

(2011) Jianzhang Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of the TLR3/dsRNA Complex

(2011) Kui Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like receptor signaling in cell proliferation and survival

(2009) Xinyan Li et al.   CYTOKINE