Article
Immunology
Anne-Charlotte Antoni, Ekaterina Pylaeva, Bettina Budeus, Jadwiga Jablonska, Ludger Klein-Hitpass, Marcel Dudda, Stefanie B. Flohe
Summary: CD8(+) T cells sense TLR2 signals and control the number and function of de novo differentiating DCs in the bone marrow during sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Luis Alejandro Zuniga, Torben Lessmann, Karan Uppal, Nicola Bisek, Enping Hong, Caroline E. Rasmussen, Jens-Jakob Karlsson, Joachim Zettler, Lars Holten-Andersen, Kathy Bang, Dhruv Thakar, Yu-Chi Lee, Salomon Martinez, Simran Singh Sabharwal, Sebastian Stark, Frank Faltinger, Oliver Kracker, Samuel Weisbrod, Robin Mueller, Tobias Voigt, Kornelia Bigott, Mohammad Tabrizifard, Vibeke Miller Breinholt, Amer M. Mirza, David B. Rosen, Kennett Sprogoe, Juha Punnonen
Summary: The TransCon TLR7/8 Agonist has been developed as a sustained-release prodrug of resiquimod, showing potent anti-tumor effects and activation of immune cells in the tumor microenvironment when used alone or in combination with systemic immunotherapy. This study highlights the potential of TransCon TLR7/8 Agonist as a novel intratumoral TLR agonist for cancer therapy.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Xin Li, Shuai Jiang, Li Sun
Summary: This study identified two muscle-type creatine kinases (CsCKM-1 and CsCKM-2) from the tongue sole fish and revealed their role in antimicrobial immunity. The results showed that CsCKM-1/2 function as damage-associated molecular pattern (DAMP) molecules and play an important role in antimicrobial immunity via interaction with TLR2. Furthermore, bacterial infection regulated the expression of CsCKM-1/2 in tongue sole tissues and induced their release into serum.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yanlin Chen, Siying Zhi, Jiaxin Ou, Junbin Gao, Lu Zheng, Meixin Huang, Shaohua Du, Liu Shi, Yingfeng Tu, Kui Cheng
Summary: Immunotherapy has potential but low clinical response rate, so combined therapy is needed. This study designs cancer cell membrane-coated nanoparticles that combine PDT, TLR7 agonist, and tumor antigen to enhance therapeutic efficacy.
Article
Immunology
Andreja Novak, Elder Pupo, Esther van't Veld, Victor P. M. G. Rutten, Femke Broere, Arjen Sloots
Summary: This study reveals that TLR2 and TLR4 are involved in the recognition of Leptospira strains used in canine Leptospira vaccines. The findings contribute to the understanding of Leptospira-induced innate immune responses in dogs, humans, and mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xinhai Zhu, Ke Li, Guichao Liu, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu, Ligong Lu, Peng Li
Summary: Recent studies have shown that gut microbiota and their metabolites can modulate the antitumor immunity of immune cells, but the underlying mechanisms are unclear. This study found that the serum level of butyric acid is correlated with the expression of PD-1 on CD8(+) and V?9 Vd2 T cells in patients with NSCLC. Patients who responded to anti-PD-1 therapy had higher levels of acetic acid, propionic acid, and butyric acid. Depletion of gut microbiota decreased butyrate levels in feces and serum of tumor-bearing mice.
Article
Chemistry, Applied
Hong-Yan Wang, Ji-Chun Ge, Feng-Yun Zhang, Xue-Qiang Zha, Jian Liu, Qiang-Ming Li, Jian-Ping Luo
Summary: The study demonstrated that homogeneous Dendrobium officinale polysaccharide can inhibit tumor growth by promoting M1 polarization of TAMs.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Marie-Christine Bartens, Amanda J. Gibson, Graham J. Etherington, Federica Di Palma, Angela Holder, Dirk Werling, Sam Willcocks
Summary: Research suggests that there are differences in the response to mycobacterial antigens between Brown Swiss and Holstein Friesian cattle, potentially due to single nucleotide polymorphisms in the TLR2 gene.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marie-Christine Bartens, Amanda J. Gibson, Graham J. Etherington, Federica Di Palma, Angela Holder, Dirk Werling, Sam Willcocks
Summary: TLR2 gene polymorphisms, particularly the H326Q SNP, significantly influence macrophage responses to mycobacterial antigens and lipopeptide ligands in cows. Differences in TLR2 responses between Bos taurus and Bos indicus cattle may contribute to their varying susceptibility to mycobacterial infection. The study also demonstrates the importance of TLR2 as a major pattern recognition receptor in the response to mycobacterial antigens in mammalian species.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuquan Zhang, Yu Liu, Ji Zhou, Jiaxin Wang, Guangyi Jin, Xiaodong Wang
Summary: A novel tumor vaccine containing MUC1 antigen and two adjuvants was developed by the research group, which effectively and safely prevented and treated tumors expressing MUC1 antigen by enhancing specific humoral and cellular immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Kennedy K. S. Tobin, Hidehiro Yamane, Charles-Antoine Dutertre, Ahad Khalilnezhad, Glennys Reynoso, Vincent L. Coble, Geoffrey M. Lynn, Matthew P. Mule, Andrew J. Martins, John P. Finnigan, Xiao Meng Zhang, Jessica A. Hamerman, Nina Bhardwaj, John S. Tsang, Heather D. Hickman, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: The study demonstrates that using a self-assembling nanoparticle vaccine and adjuvant can expand stem-like CD8(+) T cells, optimize anti-tumor immunity, and enhance the strength and effectiveness of the anti-tumor response.
Article
Oncology
Stephanie Corgnac, Isabelle Damei, Gwendoline Gros, Aziza Caidi, Stephane Terry, Salem Chouaib, Marc Deloger, Fathia Mami-Chouaib
Summary: This study investigates the immunological characteristics of human lung cancer stem cells (CSC) and their interactions with resident memory T cells in the tumor microenvironment. The researchers found that CSC exhibit partial resistance to T-cell-mediated cytotoxicity and gain sensitivity to non-memory T-cell-mediated killing by expressing intercellular adhesion molecule-1 (ICAM-1). These findings support the rational design of immunotherapeutic strategies targeting CSC to optimize anticancer treatments by enhancing their responsiveness to specific T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Yatong Chen, Jing Xu, Xiaodong Wu, Hui Yao, Zhou Yan, Ting Guo, Wenjing Wang, Peixiao Wang, Yu Li, Xiangmin Yang, Hao Li, Huijie Bian, Zhi-Nan Chen
Summary: Deletion of CD147 in T cells limits tumor growth in mouse melanoma and lung cancer. CD147 is upregulated in CD8(+) TILs and coexpressed with immune-checkpoint molecules, leading to increased antitumor responses and potential as a target for cancer immunotherapy.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Jianchun Zhou, Yu Xu, Guansong Wang, Tonghua Mei, Hao Yang, Yuliang Liu
Summary: Treatment with TLR7 agonist R848 has shown effectiveness in lung cancer by targeting macrophages and activating immune responses, resulting in reduced tumor burden and prolonged survival. R848 treatment promotes the activation of DCs and NK cells, increases T helper cell-associated cytokines, and alters the proportion of immune cells in the tumor microenvironment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Qian Li, Jun Wang, Heba Islam, Carsten Kirschning, Hongzhou Lu, Daniel Hoffmann, Ulf Dittmer, Mengji Lu
Summary: Host immune control is crucial in resolving primary hepatitis B virus (HBV) infections. This study found that TLR2 mRNA accumulation is most impacted during woodchuck hepatitis virus (WHV) infection resolution, with B-cell TLR2 activation playing a key role in HBV infection resolution.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Shuwen Liu, Yuanyuan Chen, Tianming Du, Wencong Zhao, Xuejing Liu, Heng Zhang, Qing Yuan, Liang Gao, Yuhui Dong, Xueyun Gao, Yong Gong, Peng Cao
Summary: In cyanobacteria and algae, flavodoxin (Fld) acts as an electron carrier during photosynthesis under stress conditions. This study presents the crystal structures of apo-Fld from Synechococcus sp. PCC 7942, revealing a potential dimer-monomer transition mechanism. The dimer serves as a standby state to stabilize itself, while the monomer is ready to bind FMN. Additionally, a docking model of the cyanobacterial Fld-FNR complex is proposed, highlighting the interactions between Fld and FNR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Huimei Wu, Jiaxin Ou, Kangxin Li, Tingting Wang, Kutty Selva Nandakumar
Summary: Psoriasis is a genetically determined and immune system-mediated autoimmune disease that is triggered by environmental factors. Different animal models, such as mannan-induced and imiquimod-induced models, are used to study the complex pathological mechanisms of psoriasis. Mannan-induced psoriasis model produces more severe symptoms and better disease relapse than the imiquimod model. Furthermore, the immune response and cytokine expression differ between the two models. Dexamethasone treatment effectively reduces the symptoms induced by mannan. The mannan-induced psoriasis model is simpler, more cost-effective, and less harmful to mice, making it a potential choice for studying chronic psoriasis.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Immunology
Yanpeng Li, Haodong Cui, Shipeng Li, Xingyan Li, Hongtao Guo, Kutty Selva Nandakumar, Zhilei Li
Summary: Research has shown that Kaempferol can improve psoriasis and alleviate its skin lesions. It exerts its therapeutic effects by modulating the IFN-gamma-induced JAK-STAT signaling pathway and reducing the number of inflammatory cells. These findings provide a basis for clinical application.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Immunology
Kutty Selva Nandakumar
Article
Engineering, Environmental
Shuwen Liu, Qiulong Gao, Kaiming Hou, Zhangpeng Li, Jinqing Wang, Shengrong Yang
Summary: From the standpoint of fusion of solid and liquid lubrication, solvent-free MXene nanofluids were synthesized and demonstrated excellent friction-reduction and anti-wear properties even under high velocity, elevated temperature, and heavy load conditions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Food Science & Technology
Tian Lan, Jiaqi Wang, Shihan Bao, Qinyu Zhao, Xiangyu Sun, Yulin Fang, Tingting Ma, Shuwen Liu
Summary: This review systematically examines the relationship between fruit and vegetable juice (FVJ) processing and its nutrition and function in the past 10 years, highlighting the impact of processing technology on the nutrient and functional components of FVJ, and providing new perspectives for future studies.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Computer Science, Artificial Intelligence
Yun Zhu, Chengjian Gong, Shuwen Liu, Zhiyue Yu, Hanzeng Shao, Gaohang Yu
Summary: This paper proposes a multi-channel weighted truncated WSNM model based on the WSNM optimization framework for RGB colour image denoising. The proposed model is significantly improved by the optimization methods of superposition and truncation. It is also generalized to the tensor space and employed for the infrared imaging target detection based on the spatial-temporal tensor model for the first time. The efficiency and accuracy of the algorithm are verified through extensive experiments on real infrared data.
IET IMAGE PROCESSING
(2023)
Article
Chemistry, Multidisciplinary
Abdullah Khamis Ali Al Saidi, Adibehalsadat Ghazanfari, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Dejun Zhao, Ying Liu, So Hyeon Yang, Dong Wook Hwang, Ji-ung Yang, Ji Ae Park, Jae Chang Jung, Sung-Wook Nam, Yongmin Chang, Gang Ho Lee
Summary: Ultrasmall platinum nanoparticles (Pt-NPs) coated with three types of hydrophilic and biocompatible polymers were successfully synthesized using a one-pot polyol method. The polymer-coated Pt-NPs showed excellent stability and low cellular toxicity. They also exhibited stronger X-ray attenuation power compared to a commercial iodine contrast agent, indicating their potential as computed tomography contrast agents.
Review
Cell Biology
Haifeng Zeng, Shaoshen Guo, Xuancheng Ren, Zhenkun Wu, Shuwen Liu, Xingang Yao
Summary: Extracellular vesicles, including ectosomes and exosomes, have emerged as promising natural carriers for drug delivery. Exosomes, which are 30-100 nm in diameter and possess a lipid bilayer, have high biocompatibility, stability, and low immunogenicity, making them desirable for cargo delivery. Loading cargo into exosomes, however, remains challenging despite various strategies developed. This review provides an overview of current cargo delivery strategies using exosomes and summarizes recent approaches for loading small-molecule, nucleic acid, and protein drugs into exosomes, offering insights for more efficient drug delivery.
Review
Immunology
Akhilesh Kumar Shakya, Buddhadev Mallick, Kutty Selva Nandakumar
Summary: Oral immune tolerance is a physiological process to achieve tolerance against autoimmunity by ingesting self-antigens or other therapeutics. At the cellular level, it suppresses autoimmune diseases by activating regulatory T cells (Tregs) and causing anergy or deletion of autoreactive T cells, affecting B cell tolerance. Various antigen/drug delivery tools and approaches have been explored to successfully demonstrate oral immune tolerance, but limitations such as variation in results, dose optimization, and undesirable immune system activation exist. This review discusses the phenomenon, mechanisms, delivery tools and strategies, and challenges of oral tolerance.
Article
Geography
Han Zhang, Bing-Bing Zhou, Shuwen Liu, Guohua Hu, Xing Meng, Xiaojuan Liu, Hong Shi, Yukun Gao, Haiyan Hou, Xia Li
Summary: With the patient-mobility policy and intercity transportation in China, interprovincial patient mobility has become important, but its impact on high-quality healthcare delivery is still unknown. This study analyzed the accessibility of township-level divisions to tertiary hospitals in various patient-mobility scenarios considering different transportation systems. The results showed that high-speed rail had the largest influence on high-quality healthcare utilization, while air transport was insignificant. High-speed rail can promote equitable distribution of healthcare, reducing the Gini index and urban-rural disparity in accessibility.
Review
Immunology
Akhilesh Kumar Shakya, Kutty Selva Nandakumar
Summary: Activation of the immune system is crucial for designing new antigen/drug delivery systems and studying disease pathogenesis. Polymers are often needed to assist in controlling the release of antigens and efficiently activating the immune system. Different functional groups of polymers have different applications, such as protein-based antigens and nucleic acid-based antigens. Polymers can also be used in cancer immunotherapy and developing disease models.
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Immunology
Peng Gu, Ruofan Liu, Qin Yang, Li Xie, Rongjuan Wei, Jiaxin Li, Fengyi Mei, Tao Chen, Zhenhua Zeng, Yan He, Hongwei Zhou, Hongjuan Peng, Kutty Selva Nandakumar, Huikuan Chu, Yong Jiang, Wei Gong, Ye Chen, Bernd Schnabl, Peng Chen
Summary: The level of Candida albicans was decreased in bacterial sepsis patients, and the supernatant of Candida albicans culture showed bactericidal activity and improved sepsis symptoms. Phenylpyruvate (PPA) derived from Candida albicans enhanced the bactericidal activity of macrophages by binding to SIRT2 and increasing ROS production. PPA also correlated with the severity of sepsis in patients, highlighting the role of commensal fungi in bacterial disease modulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biology
Huimei Wu, Kutty Selva Nandakumar
Summary: This article introduces a new psoriasis model which has the features of convenient and rapid induction, severe disease course and short duration. It can be used to study and evaluate the development and treatment of psoriasis.