Omega-3 Versus Omega-6 Fatty Acid Availability is Controlled by Hydrophobic Site Geometries of Phospholipase A2s
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Omega-3 Versus Omega-6 Fatty Acid Availability is Controlled by Hydrophobic Site Geometries of Phospholipase A2s
Authors
Keywords
-
Journal
JOURNAL OF LIPID RESEARCH
Volume -, Issue -, Pages 100113
Publisher
Elsevier BV
Online
2021-08-30
DOI
10.1016/j.jlr.2021.100113
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A2s to Adrenic Acid Mobilization in Murine Macrophages
- (2020) Patricia Monge et al. Biomolecules
- Substrate specific inhibition constants for phospholipase A2 acting on unique phospholipid substrates in mixed micelles and membranes using lipidomics
- (2019) Varnavas D Mouchlis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterization of Lipid–Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation
- (2019) Melanie P. Muller et al. CHEMICAL REVIEWS
- Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity
- (2018) Varnavas D. Mouchlis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Factors regulating the substrate specificity of cytosolic phospholipase A 2 -alpha in vitro
- (2016) Krishna Chaithanya Batchu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A 2
- (2016) Varnavas D. Mouchlis et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure–Activity Relationships
- (2016) Varnavas D. Mouchlis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease
- (2016) Fabrizio Giordanetto et al. ACS Medicinal Chemistry Letters
- DHA Effects in Brain Development and Function
- (2016) Lotte Lauritzen et al. Nutrients
- CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
- (2015) Jumin Lee et al. Journal of Chemical Theory and Computation
- A new era of secreted phospholipase A2
- (2015) Makoto Murakami et al. JOURNAL OF LIPID RESEARCH
- Calcium-independent phospholipases A2and their roles in biological processes and diseases
- (2015) Sasanka Ramanadham et al. JOURNAL OF LIPID RESEARCH
- Cytosolic phospholipase A2: physiological function and role in disease
- (2015) Christina C. Leslie JOURNAL OF LIPID RESEARCH
- Selectivity of cytosolic phospholipase A2 type IV toward arachidonyl phospholipids
- (2015) Melanie Grandits et al. JOURNAL OF MOLECULAR RECOGNITION
- Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates
- (2015) Varnavas D. Mouchlis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations
- (2014) Emilia L. Wu et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A2-VIA (iPLA2β)-knockout mice
- (2012) Yewon Cheon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Fluoroketone Inhibition of Ca2+-Independent Phospholipase A2 through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics
- (2012) Yuan-Hao Hsu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
- (2011) Edward A. Dennis et al. CHEMICAL REVIEWS
- Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A2 Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes
- (2011) G. Beck et al. JOURNAL OF NEUROSCIENCE
- Evidence for proteolytic processing and stimulated organelle redistribution of iPLA2β
- (2010) Haowei Song et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice
- (2010) Mireille Basselin et al. JOURNAL OF LIPID RESEARCH
- Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
- (2010) Jeffery B. Klauda et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Thematic Review Series: Proteomics.An integrated omics analysis of eicosanoid biology,
- (2009) Matthew W. Buczynski et al. JOURNAL OF LIPID RESEARCH
- Location of Inhibitors Bound to Group IVA Phospholipase A2Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry
- (2009) John E. Burke et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rapid β-oxidation of eicosapentaenoic acid in mouse brain: An in situ study
- (2009) Chuck T. Chen et al. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now