The multifaceted role of cathepsins in liver disease

Inhibition of JNK increases the sensitivity of hepatocellular carcinoma cells to lysosomotropic drugs via LAMP2A destabilization

(2021) Enrico Desideri et al.   Cell Death Discovery

Yeast β-D-glucan exerts anti-tumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis

(2020) Ningning Wang et al.   Redox Biology

TBBPA regulates calcium-mediated lysosomal exocytosis and thereby promotes invasion and migration in hepatocellular carcinoma

(2020) Liang Lyu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis

(2020) Wenqian Fang et al.   Translational Research

CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma

(2020) Shi-Jie Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

(2020) Tulasi Yadati et al.   Cells

Quantitative proteomics identifies a plasma multi-protein model for detection of hepatocellular carcinoma

(2020) Zhenhua Du et al.   Scientific Reports

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

(2020) Ines C. M. Simoes et al.   Antioxidants

Daurisoline inhibits hepatocellular carcinoma progression by restraining autophagy and promoting cispaltin-induced cell death

(2020) Legang Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis—A multicentre study

(2020) Ayman S. Bannaga et al.   EBioMedicine

Proteases: History, discovery, and roles in health and disease

(2019) Judith S. Bond   JOURNAL OF BIOLOGICAL CHEMISTRY

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux

(2019) Xiaoting Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cathepsin C Interacts with TNF-α/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma

(2019) Guo-Pei Zhang et al.   Cancer Research and Treatment

Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in Sprague–Dawley Rats †

(2019) Princy Khurana et al.   Biomolecules

Targeted Nanoparticles for Co-Delivery of 5-FU and Nitroxoline, a Cathepsin B Inhibitor, in HepG2 Cells of Hepatocellular Carcinoma

(2019) Jaleh Varshosaz et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis

(2019) Ye Tao et al.   CHEMOSPHERE

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis

(2018) Xiaojuan Wang et al.   FASEB JOURNAL

Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation

(2018) Yong Tang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

NLRP3 inflammasome activation in hepatic stellate cells induces murine liver fibrosis

(2018) Maria Eugenia Inzaugarat et al.   HEPATOLOGY

Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

(2018) Tianming Qiu et al.   Cell Death & Disease

Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid–binding protein

(2017) Simeon Thibeaux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin D regulates lipid metabolism in murine steatohepatitis

(2017) Tom Houben et al.   Scientific Reports

LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes

(2016) Allyson N. Hamlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

(2016) Jian Ruan et al.   Molecular Cancer

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

(2016) Sofie M. A. Walenbergh et al.   Scientific Reports

Plasma Cathepsin D Levels: A Novel Tool to Predict Pediatric Hepatic Inflammation

(2015) Sofie M A Walenbergh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis

(2015) Tzu-Min Hung et al.   AMERICAN JOURNAL OF PATHOLOGY

Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting

(2015) Sandra Markmann et al.   TRAFFIC

Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma

(2015) ZHI ZHANG et al.   Oncology Letters

Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma

(2014) Terence Kin-Wah Lee et al.   HEPATOLOGY

Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression

(2014) ZONG-ZHEN XU et al.   Molecular Medicine Reports

A4383C and C76G SNP in Cathepsin B is respectively associated with the high risk and tumor size of hepatocarcinoma

(2014) Tsung-Po Chen et al.   TUMOR BIOLOGY

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

(2013) Yuka Fukuo et al.   HEPATOLOGY RESEARCH

Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

(2013) Qun Wang et al.   Journal of Translational Medicine

Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro

(2012) Qi Fan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

(2012) Chiara Ullio et al.   JOURNAL OF LIPID RESEARCH

Interaction of the Hepatitis B Spliced Protein with Cathepsin B Promotes Hepatoma Cell Migration and Invasion

(2012) W.-N. Chen et al.   JOURNAL OF VIROLOGY

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice

(2011) Joshua E. Basford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin B Overexpression Due to Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann-Pick Disease

(2011) Anna Moles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis

(2010) Anna Moles et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteomic Expression Signature Distinguishes Cancerous and Nonmalignant Tissues in Hepatocellular Carcinoma

(2009) Nikki P. Lee et al.   JOURNAL OF PROTEOME RESEARCH

Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma

(2009) Zhuo   Molecular Medicine Reports

Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers

(2008) László Herszényi et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

(2008) Alisan Kahraman et al.   HEPATOLOGY

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

(2008) Anna Moles et al.   HEPATOLOGY

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells

(2008) Gunter Maubach et al.   MOLECULAR BIOLOGY OF THE CELL