Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development

UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop

(2020) Xu Liu et al.   Cell Death & Disease

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

(2020) Linda Kachuri et al.   Nature Communications

Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany

(2020) Haixin Yu et al.   Clinical Epigenetics

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

(2019) Vitor H. Teixeira et al.   NATURE MEDICINE

Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons

(2019) Shanshan Lin et al.   Clinical Epigenetics

Paternal benzo[a]pyrene exposure alters the sperm DNA methylation levels of imprinting genes in F0 generation mice and their unexposed F1-2 male offspring

(2019) Wenping Zhang et al.   CHEMOSPHERE

Appraising the causal relevance of DNA methylation for risk of lung cancer

(2019) Thomas Battram et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Particulate matter air pollution and the expression of microRNAs and pro-inflammatory genes: Association and mediation among children in Jinan, China

(2019) Jie Li et al.   JOURNAL OF HAZARDOUS MATERIALS

LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[ a ]pyrene

(2018) Ye Fu et al.   CHEMOSPHERE

The influence of specific atmospheric circulation types on PM 10 -bound benzo(a)pyrene inhalation related lung cancer risk in Barcelona, Spain

(2018) Konstantinos Dimitriou et al.   ENVIRONMENT INTERNATIONAL

Embryonic exposure to benzo(a)pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation

(2018) Dongxu Gao et al.   ENVIRONMENTAL POLLUTION

Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1

(2018) Suping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

(2018) Elmar W. Tobi et al.   Science Advances

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells

(2018) Volodymyr Tryndyak et al.   FOOD AND CHEMICAL TOXICOLOGY

Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset

(2018) Kifayat Ullah et al.   FEBS Journal

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

(2018) Erick Forno et al.   Lancet Respiratory Medicine

Benzo(a)pyrene degradation by cytochrome P450 hydroxylase and the functional metabolism network of Bacillus thuringiensis

(2018) Qiying Lu et al.   JOURNAL OF HAZARDOUS MATERIALS

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers

(2017) Theresa Ryan Stueve et al.   HUMAN MOLECULAR GENETICS

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Risk factors for lung cancer worldwide

(2016) Jyoti Malhotra et al.   EUROPEAN RESPIRATORY JOURNAL

DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk

(2016) Laura Baglietto et al.   INTERNATIONAL JOURNAL OF CANCER

Development and Validation of Risk Models to Select Ever-Smokers for CT Lung Cancer Screening

(2016) Hormuzd A. Katki et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of environmental benzo[ a ]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case–control study

(2016) Meiping Tian et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes

(2015) Eric Soupene et al.   JOURNAL OF LIPID RESEARCH

Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer

(2015) Andrew E. Teschendorff et al.   JAMA Oncology

Benzo(a)pyrene promotes A549 cell migration and invasion through up-regulating Twist

(2014) Yadong Wang et al.   ARCHIVES OF TOXICOLOGY

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy

(2014) A Paziewska et al.   BRITISH JOURNAL OF CANCER

Screening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation

(2013) Linda L. Humphrey et al.   ANNALS OF INTERNAL MEDICINE

Dose-Response Relationships of Polycyclic Aromatic Hydrocarbons Exposure and Oxidative Damage to DNA and Lipid in Coke Oven Workers

(2013) Dan Kuang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

TNFα signals through specialized factories where responsive coding and miRNA genes are transcribed

(2012) Argyris Papantonis et al.   EMBO JOURNAL

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[ a ]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood

(2012) Julie B. Herbstman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Maternal Exposure to Polycyclic Aromatic Hydrocarbons and 5’-CpG Methylation of Interferon-γ in Cord White Blood Cells

(2012) Wan-yee Tang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nature and sources of particle associated polycyclic aromatic hydrocarbons (PAH) in the atmospheric environment of an urban area

(2012) M.S. Callén et al.   ENVIRONMENTAL POLLUTION

Prolonged Exposure to Particulate Pollution, Genes Associated with Glutathione Pathways, and DNA Methylation in a Cohort of Older Men

(2011) Jaime Madrigano et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Lung cancer risk in relation to traffic-related nano/ultrafine particle-bound PAHs exposure: A preliminary probabilistic assessment

(2011) Chung-Min Liao et al.   JOURNAL OF HAZARDOUS MATERIALS

Reduction of benzo[a]pyrene with acid-activated magnesium metal in ethanol: A possible application for environmental remediation

(2011) Marc R. Elie et al.   JOURNAL OF HAZARDOUS MATERIALS

Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer

(2011) Yong-Jae Kwon et al.   Journal of Thoracic Oncology

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Role of Interferon α (IFNα)-inducible Schlafen-5 in Regulation of Anchorage-independent Growth and Invasion of Malignant Melanoma Cells

(2010) Efstratios Katsoulidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[ a ]pyrene

(2009) Shengli Shi et al.   CARCINOGENESIS