Local memory CD4 T cell niches in respiratory viral infection

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

(2021) Young Min Son et al.   Science Immunology

T resident helper cells promote humoral responses in the lung

(2021) Nivedya Swarnalekha et al.   Science Immunology

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

(2021) Peter A. Szabo et al.   IMMUNITY

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

(2021) Brigette C. Duckworth et al.   NATURE IMMUNOLOGY

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

(2021) Yu Zhao et al.   Science Immunology

Vaccine Breakthrough Infections with SARS-CoV-2 Variants

(2021) Ezgi Hacisuleyman et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm

(2020) Mikel Ruterbusch et al.   Annual Review of Immunology

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection

(2020) J. Michael Stolley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung

(2020) Kun He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-term maintenance of lung resident memory T cells is mediated by persistent antigen

(2020) Ida Uddbäck et al.   Mucosal Immunology

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

(2020) Rachel Wong et al.   IMMUNITY

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok

(2019) Thomas Ciucci et al.   IMMUNITY

The Multifaceted B Cell Response to Influenza Virus

(2019) Jonathan H. Lam et al.   JOURNAL OF IMMUNOLOGY

De novo design of potent and selective mimics of IL-2 and IL-15

(2019) Daniel-Adriano Silva et al.   NATURE

CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses

(2019) Lalit K. Beura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

(2019) Madelene W. Dahlgren et al.   IMMUNITY

Location, location, location: Tissue resident memory T cells in mice and humans

(2019) Peter A. Szabo et al.   Science Immunology

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

(2019) Maria Carolina Amezcua Vesely et al.   CELL

Lessons From Influenza Pandemics of the Last 100 Years

(2019) Arnold S Monto et al.   CLINICAL INFECTIOUS DISEASES

Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection

(2019) Aleks Guvenel et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

(2018) Andrea J. Sant et al.   IMMUNOLOGICAL REVIEWS

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

(2017) A E Oja et al.   Mucosal Immunology

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Do Memory B Cells Form Secondary Germinal Centers?

(2017) Mark J. Shlomchik   Cold Spring Harbor Perspectives in Biology

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

(2016) Salvador Iborra et al.   IMMUNITY

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma

(2016) Brian D. Hondowicz et al.   IMMUNITY

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection

(2016) Nikki B. Marshall et al.   JOURNAL OF IMMUNOLOGY

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Thy1+IL-7+lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

(2016) Kenta Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

(2016) Katelyn M. Gostic et al.   SCIENCE

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells

(2016) Dana Vu Van et al.   Nature Communications

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

(2016) Niels Peter H. Knudsen et al.   Scientific Reports

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis

(2015) Albanus O. Moguche et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFN gene delivery suppresses regulatory T cells within tumors

(2014) H Hashimoto et al.   CANCER GENE THERAPY

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

(2014) Saïdi M’Homa Soudja et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Attenuation of Respiratory Syncytial Virus-Induced and RIG-I-Dependent Type I IFN Responses in Human Neonates and Very Young Children

(2014) N. Marr et al.   JOURNAL OF IMMUNOLOGY

Immunodominant CD4+ T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein

(2014) L. Chen et al.   JOURNAL OF VIROLOGY

Limited Type I Interferons and Plasmacytoid Dendritic Cells during Neonatal Respiratory Syncytial Virus Infection Permit Immunopathogenesis upon Reinfection

(2014) S. A. Cormier et al.   JOURNAL OF VIROLOGY

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

(2014) N. Iijima et al.   SCIENCE

Late Engagement of CD86 after Influenza Virus Clearance Promotes Recovery in a FoxP3+ Regulatory T Cell Dependent Manner

(2014) Emily K. Moser et al.   PLoS Pathogens

IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection

(2013) Derek A. Pociask et al.   AMERICAN JOURNAL OF PATHOLOGY

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus

(2013) Bram Slütter et al.   IMMUNITY

Viral Antigen Induces Differentiation of Foxp3+ Natural Regulatory T Cells in Influenza Virus-Infected Mice

(2013) F. Bedoya et al.   JOURNAL OF IMMUNOLOGY

IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates

(2013) Dahui You et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection

(2013) L. Hua et al.   JOURNAL OF VIROLOGY

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors

(2012) T. M. Strutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection

(2011) Daniela Damjanovic et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease

(2011) Sumanta Mukherjee et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens

(2011) Dong-Young Kim et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Control of Rapid Recall by Memory CD4 T Cells

(2011) W. Lai et al.   JOURNAL OF IMMUNOLOGY

CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation

(2011) H. Z. Qui et al.   JOURNAL OF IMMUNOLOGY

Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

(2011) M. H. Lahoud et al.   JOURNAL OF IMMUNOLOGY

Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response

(2011) R. J. Betts et al.   JOURNAL OF VIROLOGY

CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs

(2011) Jie Sun et al.   NATURE IMMUNOLOGY

Origins of CD4+ effector and central memory T cells

(2011) Marion Pepper et al.   NATURE IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Rapid Reactivation of Extralymphoid CD4 T Cells during Secondary Infection

(2011) Timothy J. Chapman et al.   PLoS One

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

Identification of a Unique Population of Tissue-Memory CD4+ T Cells in the Airways after Influenza Infection That Is Dependent on the Integrin VLA-1

(2010) T. J. Chapman et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection

(2010) R. B. Fulton et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD4 T Cells Generated from Encounter with Seasonal Influenza Viruses and Vaccines Have Broad Protein Specificity and Can Directly Recognize Naturally Generated Epitopes Derived from the Live Pandemic H1N1 Virus

(2010) K. A. Richards et al.   JOURNAL OF IMMUNOLOGY

Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice

(2010) A. Kudva et al.   JOURNAL OF IMMUNOLOGY

CD25+ Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection

(2010) D. C. P. Lee et al.   JOURNAL OF VIROLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

A Detrimental Effect of Interleukin-10 on Protective Pulmonary Humoral Immunity during Primary Influenza A Virus Infection

(2010) K. Sun et al.   JOURNAL OF VIROLOGY

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical Role of IL-17RA in Immunopathology of Influenza Infection

(2009) C. R. Crowe et al.   JOURNAL OF IMMUNOLOGY

IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge

(2009) K. K. McKinstry et al.   JOURNAL OF IMMUNOLOGY

A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

(2009) M. L. Moore et al.   JOURNAL OF VIROLOGY

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

(2009) Marion Pepper et al.   NATURE IMMUNOLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4+ T Cells

(2008) Lie Wang et al.   IMMUNITY

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

(2008) Laurel Yong-Hwa Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

(2008) L. M. Wakim et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology