An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

(2018) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E 2 suppresses human group 2 innate lymphoid cell function

(2018) Jovana Maric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology

(2018) Sachin K. Samuchiwal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

(2018) Bart Hilvering et al.   Mucosal Immunology

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

(2018) Maria M. M. Kaisar et al.   PLOS BIOLOGY

Aspirin-Exacerbated Respiratory Disease

(2018) Andrew A. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma

(2018) Kavita Pal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

(2018) Rick M. Maizels et al.   IMMUNITY

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

(2017) Megan Osbourn et al.   IMMUNITY

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways

(2017) Katharina Dietz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lack of long-term add-on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps

(2017) Laura Van Gerven et al.   LARYNGOSCOPE

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

(2017) Chris J. C. Johnston et al.   Nature Communications

Imbalance of endogenous prostanoids in moderate-to-severe asthma

(2017) Masaya Takemura et al.   ALLERGOLOGY INTERNATIONAL

Prostaglandin I2Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses

(2016) Weisong Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current concepts of severe asthma

(2016) Anuradha Ray et al.   JOURNAL OF CLINICAL INVESTIGATION

PGE2 -treated macrophages inhibit development of allergic lung inflammation in mice

(2016) Christina Draijer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

(2016) Kei E Fujimura et al.   NATURE MEDICINE

Aspirin-Exacerbated Respiratory Disease — New Prime Suspects

(2016) Tanya M. Laidlaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Prostaglandin E2 inhibits mast cell–dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor

(2015) Jesper Säfholm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

TLR2-dependent amelioration of allergic airway inflammation by parasitic nematode type II MIF in mice

(2015) M. K. Cho et al.   PARASITE IMMUNOLOGY

TNF Counterbalances the Emergence of M2 Tumor Macrophages

(2015) Franz Kratochvill et al.   Cell Reports

Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge

(2014) S. A. Mathie et al.   ALLERGY

Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling

(2014) Weisong Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotriene B4amplifies eosinophil accumulation in response to nematodes

(2014) Michael L. Patnode et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

(2014) C. Schnoeller et al.   JOURNAL OF IMMUNOLOGY

Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma

(2014) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy

(2014) H J McSorley et al.   Mucosal Immunology

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

(2013) F. O. Martinez et al.   BLOOD

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells

(2013) Zbigniew Zasłona et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Myeloid Hypoxia-Inducible Factor-1  Is Essential for Skeletal Muscle Regeneration in Mice

(2013) N. Scheerer et al.   JOURNAL OF IMMUNOLOGY

Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation

(2013) D L Clarke et al.   Mucosal Immunology

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

(2013) Julia Esser-von Bieren et al.   PLoS Pathogens

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

(2013) Mario M. Zaiss et al.   PLoS Pathogens

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus

(2012) Henry J. McSorley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Myeloid hypoxia-inducible factor 1α prevents airway allergy in mice through macrophage-mediated immunoregulation

(2012) M Toussaint et al.   Mucosal Immunology

Alternative bacterial two-component small heat shock protein systems

(2012) A. Bepperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation

(2012) T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

(2011) Nora A. Barrett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

(2011) Christian Klotz et al.   PLoS Pathogens

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

(2009) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid cells control termination of lung inflammation through the NF-κB pathway

(2008) Wei Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY