ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

(2020) Xingya Guo et al.   Molecular Cancer

ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner

(2020) Xiaolei Zhang et al.   Annals of Translational Medicine

FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling

(2020) Hao Huang et al.   CANCER RESEARCH

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

(2020) Yunhao Chen et al.   Molecular Cancer

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting oncogene mRNA translation in B cell malignancies with eFT226, a potent and selective inhibitor of eIF4A1

(2020) Peggy A Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism

(2020) Xiaochuan Liu et al.   MOLECULAR THERAPY

S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer

(2020) Hua Shen et al.   ONCOGENE

ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2α mediated glycolysis

(2020) Hao Yu et al.   Molecular Therapy-Nucleic Acids

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

(2020) Junjie Xu et al.   Molecular Cancer

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

(2020) Aline Kowalski-Chauvel et al.   Cancers

m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner

(2019) Ruifan Wu et al.   Cell Death & Disease

Ovarian Cancer: An Integrated Review

(2019) Christine Stewart et al.   Seminars in Oncology Nursing

N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance

(2019) Takeshi Fukumoto et al.   CANCER RESEARCH

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

(2019) Hongtao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Re: Loss of Nuclear Functions of HOXA10 is Associated with Testicular Cancer Proliferation

(2019) Jerome P. Richie   JOURNAL OF UROLOGY

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Regulation of Gene Expression by N-methyladenosine in Cancer

(2019) Jun Liu et al.   TRENDS IN CELL BIOLOGY

In vivo modelling of chemo-resistant neuroblastoma provides new insights into chemo-refractory disease and metastasis.

(2019) Orli Yogev et al.   CANCER RESEARCH

NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019

(2019) Deborah K. Armstrong et al.   Journal of the National Comprehensive Cancer Network

Upregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6

(2019) Mi Gong et al.   OncoTargets and Therapy

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

(2019) Dan Jin et al.   Journal of Hematology & Oncology

Tumor-suppressor role of miR-139-5p in endometrial cancer

(2018) JinHui Liu et al.   Cancer Cell International

MIR142 loss-of-function mutations derepress ASH1L to increase HOXA gene expression and promote leukemogenesis

(2018) Maria C. Trissal et al.   CANCER RESEARCH

MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10

(2018) Jinhui Liu et al.   Molecular Medicine Reports

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition

(2018) Wenfeng Hua et al.   GYNECOLOGIC ONCOLOGY

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Human m6A writers: Two subunits, 2 roles

(2017) Xiang Wang et al.   RNA Biology

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

(2015) Valentina Turinetto et al.   NUCLEIC ACIDS RESEARCH

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression

(2014) Weiwei Tang et al.   CELLULAR SIGNALLING

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE