Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
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Title
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
Authors
Keywords
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Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 3, Pages 1026-1043
Publisher
American Society for Clinical Investigation
Online
2011-02-22
DOI
10.1172/jci44972
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Note: Only part of the references are listed.- The face of Noonan syndrome: Does phenotype predict genotype
- (2010) Judith E. Allanson et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
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- (2010) J. M. Shillingford et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3 Signaling
- (2010) T. Edouard et al. MOLECULAR AND CELLULAR BIOLOGY
- A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population
- (2010) Jianjian Chen et al. MOLECULAR CARCINOGENESIS
- Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
- (2010) Xonia Carvajal-Vergara et al. NATURE
- Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes
- (2010) C. Mihl et al. Netherlands Heart Journal
- Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling
- (2009) Masaki Ieda et al. DEVELOPMENTAL CELL
- Genetic and Pathogenetic Aspects of Noonan Syndrome and Related Disorders
- (2009) Martin Zenker HORMONE RESEARCH
- Mammalian Target of Rapamycin Is a Critical Regulator of Cardiac Hypertrophy in Spontaneously Hypertensive Rats
- (2009) Will Soesanto et al. HYPERTENSION
- Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
- (2009) Norifumi Takeda et al. JOURNAL OF CLINICAL INVESTIGATION
- The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease
- (2009) W. Lieberthal et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
- (2009) Viviana Cordeddu et al. NATURE GENETICS
- A restricted spectrum of NRAS mutations causes Noonan syndrome
- (2009) Ion C Cirstea et al. NATURE GENETICS
- Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation
- (2009) T. Araki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evaluating Temsirolimus Activity in Multiple Tumors: A Review of Clinical Trials
- (2009) Janet E. Dancey et al. SEMINARS IN ONCOLOGY
- Mammalian Target of Rapamycin and Autosomal Dominant Polycystic Kidney Disease
- (2009) R.P. Wüthrich et al. TRANSPLANTATION PROCEEDINGS
- Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
- (2009) Nancy Lee et al. BMC Pharmacology & Toxicology
- The tyrosine phosphatase Shp2 (PTPN11) in cancer
- (2008) Gordon Chan et al. CANCER AND METASTASIS REVIEWS
- Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways
- (2008) Maria I. Kontaridis et al. CIRCULATION
- Shp2 Negatively Regulates Growth in Cardiomyocytes by Controlling Focal Adhesion Kinase/Src and mTOR Pathways
- (2008) Talita M. Marin et al. CIRCULATION RESEARCH
- Noonan, Costello and cardio–facio–cutaneous syndromes: dysregulation of the Ras–MAPK pathway
- (2008) William E. Tidyman et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development
- (2008) Kimihiko Oishi et al. HUMAN MOLECULAR GENETICS
- Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function
- (2008) Wei-Hua Shen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypertrophic cardiomyopathy: current understanding and treatment objectives
- (2008) G S Soor et al. JOURNAL OF CLINICAL PATHOLOGY
- The mTOR pathway and its role in human genetic diseases
- (2008) M ROSNER et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
- (2008) Thomas Thum et al. NATURE
- Leopard syndrome
- (2008) Anna Sarkozy et al. Orphanet Journal of Rare Diseases
- Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome
- (2008) M. Krenz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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