Review
Oncology
Mengjia Chen, Jianing Xue, Maoling Wang, Junyao Yang, Ting Chen
Summary: The potential coexistence of cardiovascular disease and cancer is more likely in long-term survivors due to advancements in cancer therapy. Cardiotoxicity is a well-known and concerning adverse effect of cancer treatments, which can lead to the discontinuation of life-saving anticancer treatments and negatively impact patient survival. Different anticancer treatments have varying effects on the cardiovascular system, and the incidence of cardiovascular events also varies among different tumor protocols. Comprehensive cardiovascular risk assessment and clinical monitoring should be considered for cancer treatments, with emphasis on baseline cardiovascular evaluation risk before initiating therapy. Additionally, cardio-oncology services are needed to identify and reduce cardiovascular side effects, as well as minimize long-term cardiotoxic effects.
Review
Cardiac & Cardiovascular Systems
Yinghui Wang, Yonggang Wang, Xiaorong Han, Jian Sun, Cheng Li, Binay Kumar Adhikari, Jin Zhang, Xiao Miao, Zhaoyang Chen
Summary: Cardiovascular disease (CVD) and cancer are leading causes of death worldwide. The adverse effects of anti-tumor therapy, particularly on the cardiovascular system, have gained significant attention. Incidence of cardiovascular events is higher than tumor recurrence rate, and CVD and malignant tumors share common risk factors. Clinicians should understand this relationship, provide primary and secondary prevention strategies, and follow proper treatment methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Anja Karlstaedt, Matthew Barrett, Ray Hu, Seth Thomas Gammons, Bonnie Ky
Summary: An important priority in cardiovascular care for oncology patients is to reduce morbidity and mortality, and improve the quality of life in cancer survivors. Basic and translational research efforts are crucial for understanding the molecular mechanisms of cardiovascular diseases in cancer patients and survivors, and for identifying new therapeutic targets. Understanding the metabolic interaction between cancer and the heart, along with providing imaging techniques to support research studies and clinical management, are essential for advancing our understanding of metabolism in cardio-oncology.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Irma Bisceglia, Maria Laura Canale, Nicola Silvestris, Giuseppina Gallucci, Andrea Camerini, Alessandro Inno, Massimiliano Camilli, Fabio Maria Turazza, Giulia Russo, Andrea Paccone, Raffaella Mistrulli, Leonardo De Luca, Stefania Angela Di Fusco, Luigi Tarantini, Fabiana Luca, Stefano Oliva, Antonella Moreo, Nicola Maurea, Vincenzo Quagliariello, Giuseppina Rosaria Ricciardi, Chiara Lestuzzi, Damiana Fiscella, Iris Parrini, Vito Racanelli, Antonio Russo, Lorena Incorvaia, Fabio Calabro, Giuseppe Curigliano, Saverio Cinieri, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
Summary: In cancer, patients are considered survivors throughout their entire journey from initial diagnosis to the end of life. The increase in the number of cancer survivors calls for attention to therapy-related cardiovascular toxicity. Personalized care and multidisciplinary collaboration are crucial for the healthcare of cancer survivors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Immunology
Gengyu Sha, Zhengting Jiang, Wenjie Zhang, Chuwen Jiang, Daorong Wang, Dong Tang
Summary: Heat shock protein 70 (HSP70) is a highly conserved protein that acts as a molecular chaperone. It plays a regulatory role in apoptosis pathways and has both pro-tumor and anti-tumor effects. HSP70 can promote tumor progression and resistance, as well as induce anti-cancer responses. It also has potential as a target for cancer treatment, affecting chemotherapy, radiotherapy, and immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Anja Karlstaedt, Heinrich Taegtmeyer
Summary: This article discusses the role of metabolic remodeling in cancer and cardiovascular diseases, highlighting the shared mechanisms and risk factors between the two. Understanding these mechanisms will help develop better therapies and identify the risk of developing heart disease in cancer survivors.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Flavio D'Ascenzi, Francesca Anselmi, Caterina Fiorentini, Roberta Mannucci, Marco Bonifazi, Sergio Mondillo
Summary: This review focuses on investigating the origin, prevention, and reversal strategies of cardiac damage, and explores the beneficial effects of physical exercise on cancer patients. It suggests personalized exercise prescriptions and emphasizes the importance of cardiac evaluation in prescribing exercise for these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Graeme J. Koelwyn, Joseph Pierre Aboumsallem, Kathryn J. Moore, Rudolf A. de Boer
Summary: Recent studies have shown a complex relationship between cardiovascular disease (CVD) and cancer, where development of CVD before or after a cancer diagnosis can lead to increased risk of cancer and worsened outcomes for patients. This emerging concept of 'reverse-cardio-oncology' suggests that CVD can accelerate cancer pathogenesis.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joerg Herrmann, Daniel Lenihan, Saro Armenian, Ana Barac, Anne Blaes, Daniela Cardinale, Joseph Carver, Susan Dent, Bonnie Ky, Alexander R. Lyon, Teresa Lopez-Fernandez, Michael G. Fradley, Sarju Ganatra, Giuseppe Curigliano, Joshua D. Mitchell, Giorgio Minotti, Ninian N. Lang, Jennifer E. Liu, Tomas G. Neilan, Anju Nohria, Rupal O'Quinn, Iskra Pusic, Charles Porter, Kerry L. Reynolds, Kathryn J. Ruddy, Paaladinesh Thavendiranathan, Peter Valent
Summary: The discipline of Cardio-Oncology focuses on the cardiovascular care of cancer patients and the management of cardiovascular complications of cancer therapies. This document provides consensus definitions for common cardiovascular toxicities and aims to improve communication and outcomes in clinical practice and research.
EUROPEAN HEART JOURNAL
(2022)
Article
Oncology
Peter G. Doukas, Ruchi N. Patel, Vishnu Venkatesh, Sadiya S. Khan, Abigail Baldridge, Nausheen Akhter
Summary: The study aimed to optimize cardiac health of cancer patients in a cardio-oncology clinic. The research focused on breast cancer patients and found the importance of optimizing cardiovascular health in this patient population.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Camara L. Casson, Sofia A. John, Meghan C. Ferrall-Fairbanks
Summary: Cardiotoxicity is a common side-effect of cancer therapeutics, but the mechanisms underlying it are not well understood. Cardio-oncology focuses on understanding the effects of cancer and its treatment on the human heart. Mechanistic modeling approaches have been used to study the cardiovascular system and the effects of cancer treatments on the heart.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Rachel E. Ohman, Eric H. Yang, Melissa L. Abel
Summary: Minority and underresourced communities face higher rates of fatal cancer and cardiovascular disease. Disparities in treatment-associated cardiotoxicity show that black breast cancer survivors have elevated risk, while female patients treated with certain drugs have higher risks compared with male patients. Large-scale studies are needed to better understand racial, ethnic, socioeconomic, and gender disparities in cardio-oncology.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Juan C. Lopez-Mattei, Eric H. Yang, Maros Ferencik, Lauren A. Baldassarre, Susan Dent, Matthew J. Budoff
Summary: Cardiac computed tomography (CT) plays a crucial role in identifying cardiovascular diseases, evaluating myocardial toxicity, and is especially important in patients who are not suitable for cardiac magnetic resonance imaging.
JACC: CARDIOONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessandra Cuomo, Valentina Mercurio, Gilda Varricchi, Maria Rosaria Galdiero, Francesca Wanda Rossi, Antonio Carannante, Grazia Arpino, Luigi Formisano, Roberto Bianco, Chiara Carlomagno, Carmine De Angelis, Mario Giuliano, Elide Matano, Marco Picardi, Domenico Salvatore, Ferdinando De Vita, Erika Martinelli, Carminia Maria Della Corte, Floriana Morgillo, Michele Orditura, Stefania Napolitano, Teresa Troiani, Carlo G. Tocchetti
Summary: A large Cardio-Oncology unit in Southern Italy has described the impact on 231 consecutive patients referred to their unit, categorizing patients into three types based on their chemotherapeutic statuses. Results showed that patients already being treated with oncological treatments (Type 2) had the highest incidence of cardiovascular events, withdrawals from oncological treatments, and worst 48-month survival compared to other types.
Article
Cardiac & Cardiovascular Systems
Egle Ciburiene, Sigita Aidietiene, Greta Scerbickaite, Birute Brasiuniene, Monika Drobniene, Edita Baltruskeviciene, Tadas Zvirblis, Jelena Celutkiene
Summary: Cardio-oncology (CO) is a rapidly growing subspecialty of cardiology that aims to prevent and reverse cardiac damage caused by cancer therapies to improve the survival of cancer patients. The study findings indicate that age, previous cancer, tumor progression, kidney dysfunction, left ventricular diastolic dysfunction, and NYHA stages are associated with increased mortality.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Zamaneh Kassiri, Kara Hansell Keehan, Keith R. Brunt, Jason R. Carter, Jonathan A. Kirk, Petra Kleinbongard, Amanda J. LeBlanc, Crystal M. Ripplinger
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas G. Martin, Sara Tawfik, Christine S. Moravec, Toni R. Pak, Jonathan A. Kirk
Summary: Mutations in the sarcomere-localized cochaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and have a greater impact in male patients. The expression of BAG3 is regulated by the heat shock transcription factor-1 (HSF-1) in noncardiac cells, with a positive correlation found between HSF-1 expression and BAG3 expression in the heart. In nonischemic DCM, myofilament BAG3 expression decreases in males but remains stable in females, with this difference being linked to HSF-1 expression.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Shuchi Guo, Ama Dedo Okyere, Erin McEachern, Joshua L. Strong, Rhonda L. Carter, Viren C. Patwa, Toby P. Thomas, Melissa Landy, Jianliang Song, Ana Maria Lucchese, Thomas G. Martin, Erhe Gao, Sudarsan Rajan, Jonathan A. Kirk, Walter J. Koch, Joseph Y. Cheung, Douglas G. Tilley
Summary: This study demonstrates the importance of EGFR in maintaining contractile homeostasis in the adult heart under physiological conditions, highlighting the role of PR72 expression regulation in this process.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk
Summary: The authors demonstrate that decreased expression of BAG3 in the heart leads to reduced sarcomere protein turnover, impacting mechanical function, and that sarcomere force-generating capacity can be restored through BAG3 gene therapy.
NATURE COMMUNICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Keith R. Brunt, Jonathan A. Kirk, Petra Kleinbongard, John W. Calvert, Lisandra E. de Castro Bras, Kristine Y. DeLeon-Pennell, Dominic P. Del Re, Nikolaos G. Frangogiannis, Stefan Frantz, Richard J. Gumina, Ganesh V. Halade, Steven P. Jones, Rebecca H. Ritchie, Francis G. Spinale, Edward B. Thorp, Crystal M. Ripplinger, Zamaneh Kassiri
Summary: This study evaluated different methods for inducing myocardial infarction in mouse models, identified opportunities for consolidating methods, and recognized that reperfused and nonreperfused myocardial infarctions yield different responses. The overall goal of compiling this consensus statement is to unify best practices regarding mouse myocardial infarction models to enhance interpretation and enable comparative examination across studies and laboratories. These guidelines aim to establish rigor and reproducibility, providing greater potential for clinical translation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Papadaki, Theerachat Kampaengsri, Samantha K. Barrick, Stuart G. Campbell, Dirk von Lewinski, Peter P. Rainer, Samantha P. Harris, Michael J. Greenberg, Jonathan A. Kirk
Summary: The study found that increased glycation of sarcomeric actin in diabetic patients may contribute to the development of HF. This suggests that myofilament glycation could be a promising therapeutic target for preventing HF in diabetics.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Poettler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner
Summary: This study evaluated the effects of the pan-HDAC inhibitor SAHA on cardiac function in a heart failure model and found that SAHA can improve cardiomyocyte and contractile protein function by increasing myofilament calcium sensitivity and reducing diastolic tension.
Editorial Material
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Jason R. Carter, Crystal M. Ripplinger, Zamaneh Kassiri, Kara Hansell Keehan, Keith R. Brunt, Jonathan A. Kirk, Petra Kleinbongard, Amanda J. LeBlanc
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Zamaneh Kassiri, Amanda J. LeBlanc, Crystal M. Ripplinger, Jonathan A. Kirk, Jason R. Carter, Petra Kleinbongard, Keith R. Brunt
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Petra Kleinbongard, Zamaneh Kassiri, Jason R. Carter, Kara Hansell Keehan, Crystal M. Ripplinger, Amanda J. LeBlanc, Keith R. Brunt, Jonathan A. Kirk
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Physiology
Weikang Ma, Kyoung Hwan Lee, Christine E. Delligatti, M. Therese Davis, Yahan Zheng, Henry Gong, Jonathan A. Kirk, Roger Craig, Thomas Irving
Summary: Our study validates the use of liquid nitrogen-frozen and cryostored porcine myocardium as a test bed for biophysical studies of cardiac muscle, which can lead to consistent results with reduced animal usage. These studies are important for understanding the physiological and pathological aspects of heart muscle. Liquid nitrogen preservation is a practical approach for structural and functional studies of myocardium.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jonathan A. Kirk
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Jonathan A. Kirk, Joseph Y. Cheung, Arthur M. Feldman
Summary: BAG3 is a protein that is expressed ubiquitously in humans, with highest levels in the heart, skeletal muscle, and central nervous system, as well as in many cancers. It plays diverse roles in both the heart and cancer cells, including apoptosis inhibition, autophagy promotion, and maintenance of cellular structure. However, targeting BAG3 function in cancer cells may pose challenges due to its essential roles in the heart.
JOURNAL OF CLINICAL INVESTIGATION
(2021)