Puerarin attenuates intracerebral hemorrhage‐induced early brain injury possibly by PI3K/Akt signal activation‐mediated suppression of NF‐κB pathway

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Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease

(2019) Tongkai Chen et al.   ACS Applied Materials & Interfaces

Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease

(2019) WenJun Yu et al.   Aging-US

Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells

(2018) Hua-fei Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

(2018) Qiquan Zhu et al.   Journal of Neuroinflammation

Puerarin prevents LPS-induced acute lung injury via inhibiting inflammatory response

(2018) Xinye Wang et al.   MICROBIAL PATHOGENESIS

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

(2018) Zhi-Gang Mei et al.   Neural Regeneration Research

Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

(2018) Zhiyi Xie et al.   NEUROPHARMACOLOGY

Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

(2018) Biyu Hou et al.   Oxidative Medicine and Cellular Longevity

Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice

(2018) Yu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

CXCL8 gene silencing promotes neuroglial cells activation while inhibiting neuroinflammation through the PI3K/Akt/NF-κB-signaling pathway in mice with ischemic stroke

(2018) Hui Lv et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB

(2017) Hua-Fei Deng et al.   LIFE SCIENCES

Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA

(2017) Hui Kong et al.   MOLECULES

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes

(2017) He Hongyun et al.   NEUROSCIENCE LETTERS

Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in an in vivo model of cerebral ischemia

(2017) Jinhao Tao et al.   Oncotarget

The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats

(2016) Dapeng Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage

(2016) Haiping Zheng et al.   CEREBROVASCULAR DISEASES

Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway

(2016) Chan-Min Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

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(2016) Qian Zhang et al.   Evidence-based Complementary and Alternative Medicine

Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-κB signaling pathway

(2016) Chi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway

(2016) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

(2016) Xin Hu et al.   Oxidative Medicine and Cellular Longevity

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Nuclear factor-κB activation in perihematomal brain tissue correlates with outcome in patients with intracerebral hemorrhage

(2015) Ze-Li Zhang et al.   Journal of Neuroinflammation

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

(2015) Sebastian Urday et al.   Nature Reviews Neurology

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats

(2015) R. Ding et al.   NEUROSCIENCE

The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia–reperfusion injury is linked to cyclin-dependent kinase 5

(2015) Feng Tian et al.   NEUROSCIENCE LETTERS

Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice

(2015) Shan-shan Zhao et al.   NEUROTOXICOLOGY

Receptor for Advanced Glycation End-Product Antagonist Reduces Blood-Brain Barrier Damage After Intracerebral Hemorrhage

(2015) F. Yang et al.   STROKE

Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response

(2015) Yuanyuan Yao et al.   Neural Regeneration Research

Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway

(2014) Xiao-ke Hao et al.   BRAIN RESEARCH

Blood–brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation

(2014) Rui Ding et al.   BRAIN RESEARCH

Repetitive Ischemic Preconditioning Attenuates Inflammatory Reaction and Brain Damage After Focal Cerebral Ischemia in Rats: Involvement of PI3K/Akt and ERK1/2 Signaling Pathway

(2014) Xian-kun Tu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

(2014) Ming Liu et al.   MEDIATORS OF INFLAMMATION

Puerarin Protects Against β-Amyloid-Induced Microglia Apoptosis Via a PI3K-Dependent Signaling Pathway

(2014) Cui Wang et al.   NEUROCHEMICAL RESEARCH

Ceftriaxone alleviates early brain injury after subarachnoid hemorrhage by increasing excitatory amino acid transporter 2 expression via the PI3K/Akt/NF-κB signaling pathway

(2014) D. Feng et al.   NEUROSCIENCE

An Update on Inflammation in the Acute Phase of Intracerebral Hemorrhage

(2014) Sheng Chen et al.   Translational Stroke Research

[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage

(2013) Tao Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice

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RadixPuerariae: An overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use

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Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat

(2013) Shuo Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury

(2013) Jia-Wei Wang et al.   JOURNAL OF SURGICAL RESEARCH

Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition

(2013) Nan Wang et al.   NEUROPHARMACOLOGY

The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats

(2013) Feng Tian et al.   NEUROSCIENCE LETTERS

Neuroprotective Effects of Puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's Disease Model in Mice

(2013) Guoqi Zhu et al.   PHYTOTHERAPY RESEARCH

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage

(2013) Basak Caner Topkoru et al.   STROKE

PHA-543613 Preserves Blood–Brain Barrier Integrity After Intracerebral Hemorrhage in Mice

(2013) Paul R. Krafft et al.   STROKE

Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats

(2012) Hock-Kean Liew et al.   Journal of Neuroinflammation

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

(2012) Bin Huang et al.   NEUROBIOLOGY OF DISEASE

Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death

(2012) Guoqi Zhu et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway

(2011) Guihua Xing et al.   BRAIN RESEARCH BULLETIN

The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia–reperfusion injury in rats

(2011) Feng Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

TLR2 Ligand Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of Phosphoinositide 3-Kinase/Akt Signaling

(2011) C. Lu et al.   JOURNAL OF IMMUNOLOGY

α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats

(2011) Kamil Duris et al.   STROKE

α7 Nicotinic Acetylcholine Receptor Agonism Confers Neuroprotection Through GSK-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage

(2011) Paul R. Krafft et al.   STROKE

Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo

(2010) Jiaming Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of nuclear factor-κB by 6-O-acetyl shanzhiside methyl ester protects brain against injury in a rat model of ischemia and reperfusion

(2010) Wanglin Jiang et al.   Journal of Neuroinflammation

Puerarinprotects against ischemic brain injury in a rat model of transient focal ischemia

(2009) Li Gao et al.   NEUROLOGICAL RESEARCH