Article
Biochemistry & Molecular Biology
Lina Jakubauskiene, Matas Jakubauskas, Gintare Razanskiene, Bettina Leber, Jennifer Weber, Lisa Rohrhofer, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The study demonstrates that pretreatment with relaxin, erythropoietin, or their combination can effectively reduce uterine tissue damage caused by ischemia-reperfusion injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Review
Pharmacology & Pharmacy
Minglang Gao, Ziyao Zhang, Kai Lai, Yu Deng, Chuanbing Zhao, Zilong Lu, Qing Geng
Summary: Puerarin has protective effects on ischemia-reperfusion injuries of organs such as the heart and brain, achieved through vasodilation and anti-free radical generation. With further research, puerarin is expected to be an effective drug for the treatment of ischemia-reperfusion injuries.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amanda Moya-Gomez, Lena Perez Font, Andreea Burlacu, Yeranddy A. A. Alpizar, Miriam Maranon Cardonne, Bert Brone, Annelies Bronckaers
Summary: ELF-EMS has significant benefits in rodent models of permanent stroke by enhancing cerebrovascular perfusion and endothelial cell nitric oxide production. However, its effect on the neuroinflammatory response and efficacy in reperfusion stroke models remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Asmaa A. Khalifa, Mennatallah A. Ali, Nahed H. Elsokkary, Samar S. Elblehi, Mahmoud M. El-Mas
Summary: This study investigated the protective effects of simultaneous exposure to a minimal dose of erythropoietin (EPO) and remote ischemic preconditioning (RIPC) against skeletal muscle ischemia and reperfusion (S-I/R) injury. The results showed that the combined application of RIPC and EPO significantly ameliorated the structural and functional abnormalities as well as mitochondrial oxidative and apoptotic damage caused by S-I/R injury.
Article
Pathology
Juthipong Benjanuwattra, Nattayaporn Apaijai, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Kannaporn Intachai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: In a model of myocardial ischemia/reperfusion injury, the timing of erythropoietin (EPO) administration was found to have varying effects on cardioprotection. EPO given during ischemia or reperfusion was shown to attenuate arrhythmia, improve cardiac function, reduce infarct size and apoptosis.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Review
Medicine, Research & Experimental
Fatemeh Sabet Sarvestani, Negar Azarpira, Ismail H. Al-Abdullah, Ali-Mohammad Tamaddon
Summary: Ischemia reperfusion injury can lead to tissue damage, especially during organ transplantation. By manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Xinming Li, Zongxin Cheng, Xiaohong Chen, Dejiang Yang, Huanhuan Li, Youqing Deng
Summary: This study found that Purpurogallin (PPG) has neuroprotective effects on cerebral ischemia/reperfusion (I/R) injury. PPG attenuates brain I/R damage by suppressing endoplasmic reticulum (ER) stress and neuroinflammation via inactivation of the TLR4/NF-kappa B pathway. PPG may be a potential candidate drug for treating cerebral I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qianqian Zhang, Min Yao, Jiajia Qi, Rui Song, Lei Wang, Jiacheng Li, Xian Zhou, Dennis Chang, Qi Huang, Lili Li, Ning Wang
Summary: The natural compound Puerarin (PUE) has a therapeutic effect on cerebral ischemia-reperfusion injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway. Experimental results showed that PUE could improve neurological deficits in rats and reduce oxidative stress levels.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Yanhui Han, Honglei Wang, Yan Wang, Pingshuan Dong, Jingjing Jia, Shaohui Yang
Summary: This study investigated the roles of puerarin and LncRNA ANRIL in myocardial ischemia-reperfusion injury. The findings suggest that puerarin protects myocardial tissues by up-regulating ANRIL and inhibiting autophagy.
CELL AND TISSUE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xiudi Zhou, Qiang Chen, Chunjing Guo, Yanguo Su, Huimin Guo, Min Cao, Zhongxin Liu, Dandan Zhang, Ningning Diao, Huaying Fan, Daquan Chen
Summary: A novel drug delivery system has been developed to precisely deliver drugs to pathological renal tissue for attenuating renal ischemia-reperfusion injury. The system exhibits responsive properties to reactive oxygen species, biocompatibility, and cell penetration. The intracellular concentration of hydrogen sulfide released by the system is threefold higher than that in the control group, and it demonstrates anti-inflammatory effects by blocking the NF-KB signaling pathway. This research provides a promising strategy for pharmaceutical treatment of renal ischemia-reperfusion injury.
Review
Biochemistry & Molecular Biology
Pasquale Pagliaro, Claudia Penna
Summary: Myocardial ischemia-reperfusion injury (MIRI) is caused by various mechanisms, including ROS production, altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ROS are also involved, leading to the opening of mPTP. NLRP3 inflammasome priming and activation play a role in these processes and are associated with cell death and endothelial dysfunction. ROS inhibitors and NLRP3 inhibitors have been studied as potential therapeutic agents in ischemic heart disease, but further research is needed to confirm their clinical use.
Review
Biochemistry & Molecular Biology
Eman Maher Zahran, Ahmed M. Sayed, Rania Alaaeldin, Mahmoud A. Elrehany, Amira R. Khattab, Usama Ramadan Abdelmohsen
Summary: This article conducts a comprehensive survey on functional food bioactives for managing or protecting against the health consequences of myocardial and cerebral ischemia. Mechanistic studies and in silico-based analyses were performed to explore their potential in targeting the complex pathophysiology of ischemic conditions. The results suggest that these functional food bioactives exhibit multifactorial effects and can be used as valuable therapeutic agents in combination with conventional drugs.
Review
Immunology
Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Summary: Recent advances in minimizing ischemia have shown promising results in reducing initial xenograft dysfunction in pig-to-non-human primate heart transplantation, indicating the significant role of ischemia reperfusion injury (IRI) in cardiac xenotransplantation. Understanding the molecular, cellular, and immune mechanisms of IRI and primary graft dysfunction in allotransplantation can help develop genetic modifications and technical strategies to minimize IRI and improve clinical xenotransplantation outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Alaa Ousta, Lin Piao, Yong Hu Fang, Adrianna Vera, Thara Nallamothu, Alfredo J. Garcia, Willard W. Sharp
Summary: This study using a mouse model found that brief asystolic CA can induce microglial activation and neurodegeneration, leading to severe neurological injury.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Bao-Hua Chao, Feng Yan, Yang Hua, Jian-Min Liu, Ge Yang, Xun-Ming Ji, Bin Peng, Guo-Guang Zhao, Yong-Jun Wang, De-Zhi Kang, Yi-Long Wang, Jin-Sheng Zeng, Lan Chu, Tian-Xiao Li, Yu-Ming Xu, Ming Liu, Li He, Yun Xu, Jiang Wu, Min Lou, Wei Yue, Lei Cao, Wen-Jun Tu, Long-De Wang
Summary: The China Stroke Prevention Project Committee has been actively promoting stroke prevention and control in China. With over 8.3 million people screened and followed up from 2012 to 2018, the committee has helped establish 380 stroke centers in mainland China and improved stroke care quality through monitoring and reporting. Further nationwide promotion of the program is needed to continue the progress.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Endocrinology & Metabolism
Wenning Fu, Chao Wang, Li Zou, Heng Jiang, Mia Miller, Yong Gan, Shiyi Cao, Hongbin Xu, Jing Mao, Shijiao Yan, Wei Yue, Feng Yan, Qingfeng Tian, Zuxun Lu
Summary: This study found significant positive relationships between obesity indicators such as BMI, WC, LAP, VAI, and BAI with the risk of diabetes. Among these indices, WC had the strongest impact on diabetes prevalence, while BAI had the weakest impact.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Clinical Neurology
Jianfeng Zhuang, Yucong Peng, Chi Gu, Huihui Chen, Zheng Lin, Hang Zhou, Xiao Wu, Jianru Li, Xiaobo Yu, Yang Cao, Hanhai Zeng, Xiongjie Fu, Chaoran Xu, Peiyu Huang, Shenglong Cao, Chun Wang, Feng Yan, Gao Chen
Summary: Wogonin enhances phagocytosis, reduces inflammation, and oxidative stress, facilitating hematoma clearance and improving neurobehavioral recovery after ICH.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Cell Biology
Huaijun Chen, Xiaobo Yu, Libin Hu, Yucong Peng, Qian Yu, Hang Zhou, Chaoran Xu, Hanhai Zeng, Yang Cao, Jianfeng Zhuang, Xiongjie Fu, Guoyang Zhou, Jianru Li, Feng Yan, Lin Wang, Gao Chen, Jingyin Chen
Summary: The pharmacological activation of Nurr1 with AQ alleviated neuron injury and neuroinflammation, potentially through the Nurr1/NF-kappa B/MMP9 pathway. AQ showed promise as a treatment strategy for subarachnoid hemorrhage by improving outcomes, reducing brain edema, and inhibiting proinflammatory cytokines.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Clinical Neurology
Xiongjie Fu, Hanhai Zeng, Jikuang Zhao, Guoyang Zhou, Hang Zhou, Jianfeng Zhuang, Chaoran Xu, Jianru Li, Yucong Peng, Yang Cao, Yin Li, Huaijun Chen, Lin Wang, Feng Yan, Gao Chen
Summary: The study shows that Dectin-1 plays a role in regulating microglia/macrophage phenotype and neuroinflammation after intracerebral hemorrhage, potentially contributing to functional recovery through the activation of the Syk/Card9/NF-kB pathway.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Wen-Jun Tu, Feng Yan, Bao-Hua Chao, Xun-Ming Ji, Longde Wang
Summary: Among stroke patients, admission to a designated SU was associated with modestly lower mortality at discharge, reduced probability of death, or being disabled at the end of follow-up.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hanhai Zeng, Xiongjie Fu, Jing Cai, Chenjun Sun, Mengyan Yu, Yucong Peng, Jianfeng Zhuang, Jingyin Chen, Huaijun Chen, Qian Yu, Chaoran Xu, Hang Zhou, Yang Cao, Libin Hu, Jianru Li, Shenglong Cao, Chi Gu, Feng Yan, Gao Chen
Summary: Neuroinflammation in patients with subarachnoid hemorrhage (SAH) is closely associated with poor prognosis, and neutrophil extracellular traps (NETs) play a key role in promoting inflammation. Inhibiting NET formation can attenuate the damage caused by neuroinflammation after SAH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Microbiology
Xiaobo Yu, Guoyang Zhou, Bo Shao, Hang Zhou, Chaoran Xu, Feng Yan, Lin Wang, Gao Chen, Jianru Li, Xiongjie Fu
Summary: Intracerebral hemorrhage (ICH) can disrupt gut microbiota balance, leading to changes in immune responses and neuroinflammation. Restoring a healthy microbiota can alleviate functional deficits and neuroinflammation after ICH.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Fangfang Zhao, Haiping Zhao, Junfen Fan, Rongliang Wang, Ziping Han, Zhen Tao, Yangmin Zheng, Feng Yan, Yuyou Huang, Lei Yu, Xu Zhang, Lianfeng Zhang, Yumin Luo, Yuanwu Ma
Summary: The study showed that knockout of miR-29a in rats aggravated neurological damage in experimental stroke rat models by promoting M1 microglial polarization and increasing glutamate release. MiR-29a-5p levels decreased in the blood and brain tissue of rat MCAO models, as well as in the peripheral blood of acute stroke patients. Additionally, miR-29a knockout enhanced infarct volume and showed M1 polarization of microglia in the MCAO rat brain.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Hanhai Zeng, Huaijun Chen, Min Li, Jianfeng Zhuang, Yucong Peng, Hang Zhou, Chaoran Xu, Qian Yu, Xiongjie Fu, Shenglong Cao, Jing Cai, Feng Yan, Gao Chen
Summary: The study revealed that NRBF2 has a protective effect on endoplasmic reticulum stress-associated neuroinflammation and oxidative stress after SAH by promoting autophagosome maturation through interactions with Rab7.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang, Feng Yan
Summary: Our study revealed that inhibiting P2X4R can promote neurofunctional recovery after ICH, transform pro-inflammatory microglia induced by ICH into an anti-inflammatory phenotype, and alleviate ICH-induced WMI. Additionally, TrkB blockage can reverse the protective effects of WMI, suggesting that P2X4R plays a crucial role in regulating WMI and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Hang Zhou, Libin Hu, Jianru Li, Wu Ruan, Yang Cao, Jianfeng Zhuang, Hangzhe Xu, Yucong Peng, Zhongyuan Zhang, Chaoran Xu, Qian Yu, Yin Li, Zhangqi Dou, Junwen Hu, Xinyan Wu, Xiaobo Yu, Chi Gu, Shenglong Cao, Feng Yan, Gao Chen
Summary: The study demonstrates the role of AXL in transforming astrocytes into a phagocytic phenotype after TBI through the AXL/STAT1/ABCA1 pathway, which helps limit neuroinflammation and improve neurological impairments. The findings provide a potential therapeutic target for TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Correction
Clinical Neurology
Xiongjie Fu, Hanhai Zeng, Jikuang Zhao, Guoyang Zhou, Hang Zhou, Jianfeng Zhuang, Chaoran Xu, Jianru Li, Yucong Peng, Yang Cao, Yin Li, Huaijun Chen, Lin Wang, Feng Yan, Gao Chen
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Wenzhen Li, Dajie Chen, Shuai Liu, Xiaojun Wang, Xiaojie Chen, Jiafeng Chen, Jing Ma, Fujian Song, Hui Li, Shijiao Yan, Xiaoxv Yin, Shiyi Cao, Yanhong Gong, Junan Liu, Wei Yue, Feng Yan, Chuanzhu Lv, Zhihong Wang, Zuxun Lu
Summary: After the update of the hypertension definition by the 2017 ACC/AHA guidelines, the prevalence of hypertension significantly increased, with newly labeled as hypertensive mainly seen in north China. Efforts should focus on improving health education, management, and interventions in the northern region.
Article
Cell Biology
Zeng Hanhai, Qin Bin, Zhou Shengjun, Li Jingbo, Guo Yinghan, Cai Lingxin, Cao Shenglong, Zhou Hang, Chen Huaijun, Zhuang Jianfeng, Peng Yucong, Fu Xiongjie, Yu Xiaobo, Tan Xiaoxiao, Li Jianru, Gu Chi, Yan Feng, Chen Gao
Summary: Neutrophils in peripheral blood were found to be higher in subarachnoid hemorrhage patients compared to healthy subjects. The presence of neutrophil extracellular traps released post-SAH could shift microglia towards a more proinflammatory phenotype, contributing to neuroinflammation and poor outcome.