5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway

Neuroprotection of granulocyte colony-stimulating factor during the acute phase of transient forebrain ischemia in gerbils

(2014) Feng Lu et al.   BRAIN RESEARCH

Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats

(2014) Lin Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke

(2014) Dhirendra Pratap Singh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

(2014) Gu Gong et al.   PLoS One

Advances and challenges in treatment and prevention of ischemic stroke

(2013) Aaron W. Grossman et al.   ANNALS OF NEUROLOGY

5-Lipoxygenase Inhibitor Zileuton Inhibits Neuronal Apoptosis Following Focal Cerebral Ischemia

(2013) Song-sheng Shi et al.   INFLAMMATION

Progesterone inhibits the expression of cycloxygenase-2 and interleukin-1β in neonatal rats with hypoxic ischemic brain damage

(2013) Xiaoyin Wang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Leptin Attenuates Cerebral Ischemia Injury through the Promotion of Energy Metabolism via the PI3K/Akt Pathway

(2013) Jinying Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability

(2013) Lipeng Dong et al.   MEDIATORS OF INFLAMMATION

Prognostic Value of Inflammatory Mediators in 1-Year Outcome of Acute Ischemic Stroke with Middle Cerebral Artery Stenosis

(2013) Xiping Gong et al.   MEDIATORS OF INFLAMMATION

Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke

(2013) Lu Yu et al.   PLoS One

Effects of Zileuton on Airway Smooth Muscle Remodeling after Repeated Allergen Challenge in Brown Norway Rats

(2013) Wei-Ji Chen et al.   RESPIRATION

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia

(2012) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model

(2012) Kumar Vaibhav et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

(2012) Peng Zhang et al.   NEUROSCIENCE LETTERS

bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways

(2012) Zhouguang Wang et al.   TOXICOLOGY LETTERS

Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats

(2011) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Acute anti-inflammatory approaches to ischemic stroke

(2010) Gregory J. Del Zoppo   Annals of the New York Academy of Sciences

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

(2010) A Rossi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats

(2010) Xian-kun Tu et al.   INFLAMMATION

New Approaches to Neuroprotective Drug Development

(2010) M. Fisher   STROKE

The cardioprotective effects of zileuton, a 5-lipoxygenase inhibitor, are mediated by COX-2 via activation of PKCδ

(2009) Hyun-Jeong Kwak et al.   CELLULAR SIGNALLING

5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9

(2009) Xian-Kun Tu et al.   NEUROLOGICAL RESEARCH

Pharmacologic Interventions for Stroke

(2009) Juan C. Chavez et al.   STROKE

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

National US Estimates of Recombinant Tissue Plasminogen Activator Use

(2008) Dawn Kleindorfer et al.   STROKE

Effects of zileuton and montelukast in mouse experimental spinal cord injury

(2007) T Genovese et al.   BRITISH JOURNAL OF PHARMACOLOGY