Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 23, Pages 2074-2080Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.147934
Keywords
nerve regeneration; brain injury; puerarin; cerebral ischemia; reperfusion injury; rats; inflammatory reaction; Toll-like receptor-4; nuclear factor kappa B; myeloid differentiation factor 88; tumor necrosis factor-alpha; middle cerebral artery occlusion; neural regeneration
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Funding
- Chinese Traditional Medical Science Foundation of Zhejiang Province in China [2010ZA072]
- Health Bureau Foundation of Zhejiang Province in China [2012ZDA023]
- Qianjiang Project of Zhejiang Science and Technology Bureau in China [2010 R10073]
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Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin (100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin significantly improved neurological deficit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-a in the ischemic region. These data indicate that puerarin exerts an anti-inflammatory protective effect on brain tissue with ischemia/reperfusion damage by down-regulating the expression of multiple inflammatory factors.
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