Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro
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Title
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro
Authors
Keywords
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Journal
Frontiers in Molecular Neuroscience
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-02-24
DOI
10.3389/fnmol.2017.00046
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Note: Only part of the references are listed.- Contribution of TARDBP to Alzheimer's Disease Genetic Etiology
- (2017) Nathalie Brouwers et al. JOURNAL OF ALZHEIMERS DISEASE
- The TDP-43 N-terminal domain structure at high resolution
- (2016) Miguel Mompeán et al. FEBS Journal
- ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
- (2016) Alexander E. Conicella et al. STRUCTURE
- In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes
- (2016) Hermann Broder Schmidt et al. Cell Reports
- ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
- (2016) Liangzhong Lim et al. PLOS BIOLOGY
- Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation
- (2016) Chien-Hao Chiang et al. Scientific Reports
- Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity
- (2016) Akira Kitamura et al. Scientific Reports
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- Frontotemporal dementia
- (2015) Jee Bang et al. LANCET
- Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism
- (2015) Lies Vanden Broeck et al. NEUROBIOLOGY OF AGING
- TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons
- (2015) R. Mutihac et al. NEUROBIOLOGY OF DISEASE
- The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity
- (2015) Quan Li et al. Nature Communications
- A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques
- (2015) Fermin Moreno et al. Acta Neuropathologica Communications
- Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress
- (2014) Rafah Mackeh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual Vulnerability of TDP-43 to Calpain and Caspase-3 Proteolysis after Neurotoxic Conditions and Traumatic Brain Injury
- (2014) Zhihui Yang et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo
- (2014) Vineeta Bhasker Tripathi et al. NEUROBIOLOGY OF DISEASE
- The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids
- (2014) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling
- (2014) Simon D’Alton et al. PLoS One
- TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo
- (2013) Darshana K. Choksi et al. HUMAN MOLECULAR GENETICS
- Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones
- (2013) Maria Udan-Johns et al. HUMAN MOLECULAR GENETICS
- Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice
- (2013) Jonathan Janssens et al. MOLECULAR NEUROBIOLOGY
- Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations
- (2013) Zhijun Zhang et al. PLoS One
- The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis
- (2013) Yoshinori Nishimoto et al. Molecular Brain
- Accelerated Disease Onset with Stabilized Familial Amyotrophic Lateral Sclerosis (ALS)-linked Mutant TDP-43 Proteins
- (2012) Shoji Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel TARDBP mutations in Nordic ALS patients
- (2012) Huei-Hsin Chiang et al. JOURNAL OF HUMAN GENETICS
- Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
- (2012) Anaïs Aulas et al. Molecular Neurodegeneration
- Screening of the TARDBP gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin
- (2012) Zhang-Yu Zou et al. NEUROBIOLOGY OF AGING
- Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
- (2012) B. Bilican et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
- (2011) Todd J Cohen et al. EMBO JOURNAL
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study
- (2011) A. Chio et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
- (2011) Ya-Fei Xu et al. Molecular Neurodegeneration
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy
- (2010) N. F. Liachko et al. JOURNAL OF NEUROSCIENCE
- Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese
- (2010) Aritoshi Iida et al. NEUROBIOLOGY OF AGING
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
- (2010) Hongxia Zhou et al. PLoS Genetics
- Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
- (2009) Manuela Neumann et al. ACTA NEUROPATHOLOGICA
- Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
- (2009) Fabienne C Fiesel et al. EMBO JOURNAL
- Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
- (2009) Takashi Nonaka et al. HUMAN MOLECULAR GENETICS
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43A315T mutation in familial motor neuron disease
- (2008) Michael A. Gitcho et al. ANNALS OF NEUROLOGY
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- Two German Kindreds With Familial Amyotrophic Lateral Sclerosis Due to TARDBP Mutations
- (2008) Peter Kühnlein et al. ARCHIVES OF NEUROLOGY
- Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
- (2008) Takashi Nonaka et al. FEBS LETTERS
- A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro
- (2008) Matthew J. Winton et al. FEBS LETTERS
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
- (2008) Vivianna M Van Deerlin et al. LANCET NEUROLOGY
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- TDP-43 Is Not a Common Cause of Sporadic Amyotrophic Lateral Sclerosis
- (2008) Rita J. Guerreiro et al. PLoS One
- A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
- (2008) B. S. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
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