Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

(2019) Mia Petljak et al.   CELL

pM to µM – Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

(2019) Mina Henes et al.   ACS Chemical Biology

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

(2019) William C Solomon et al.   NUCLEIC ACIDS RESEARCH

Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation

(2019) Tadahiko Matsumoto et al.   Scientific Reports

APOBEC3A is a prominent cytidine deaminase in breast cancer

(2019) Luis M. Cortez et al.   PLoS Genetics

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

(2018) Atanu Maiti et al.   Nature Communications

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

(2018) Tania V. Silvas et al.   Scientific Reports

Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H

(2018) Fumiaki Ito et al.   Scientific Reports

Determinants of Oligonucleotide Selectivity of APOBEC3B

(2018) Jeffrey R. Wagner et al.   Journal of Chemical Information and Modeling

Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B

(2018) Shurong Hou et al.   Journal of Chemical Theory and Computation

Base editing: precision chemistry on the genome and transcriptome of living cells

(2018) Holly A. Rees et al.   NATURE REVIEWS GENETICS

Interdependence of Inhibitor Recognition in HIV-1 Protease

(2017) Janet L. Paulsen et al.   Journal of Chemical Theory and Computation

Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins

(2017) Fumiaki Ito et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation

(2017) Xiao Xiao et al.   NUCLEIC ACIDS RESEARCH

In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

(2017) Eunji Kim et al.   Nature Communications

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

(2017) Takahide Kouno et al.   Nature Communications

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

(2017) Alexis C. Komor et al.   Science Advances

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B

(2017) Ke Shi et al.   Scientific Reports

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

(2016) Nadine M. Shaban et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease

(2016) Djadé I. Soumana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

(2016) Ciaran M Lee et al.   MOLECULAR THERAPY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

(2016) K. Nishida et al.   SCIENCE

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

Crystal structures of APOBEC3G N-domain alone and its complex with DNA

(2016) Xiao Xiao et al.   Nature Communications

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization

(2015) Markus-Frederik Bohn et al.   STRUCTURE

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of DNA Cytidine Deaminase ABOBEC3G Catalytic Deamination Domain Suggests a Binding Mode of Full-length Enzyme to Single-stranded DNA

(2014) Xiuxiu Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease

(2014) Ayşegül Özen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A computational analysis of the structural determinants of APOBEC3’s catalytic activity and vulnerability to HIV-1 Vif

(2014) Shivender M.D. Shandilya et al.   VIROLOGY

The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5′-CC to 5′-TC by a Single Amino Acid Substitution

(2013) Anurag Rathore et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

(2013) S. Harjes et al.   JOURNAL OF VIROLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

(2013) M. Mitra et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain

(2013) Markus-Frederik Bohn et al.   STRUCTURE

Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F

(2013) Karen K. Siu et al.   Nature Communications

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G

(2010) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rationalisation of the Differences between APOBEC3G Structures from Crystallography and NMR Studies by Molecular Dynamics Simulations

(2010) Flavia Autore et al.   PLoS One

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

(2010) Shivender M.D. Shandilya et al.   STRUCTURE

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

(2009) Elena Harjes et al.   JOURNAL OF MOLECULAR BIOLOGY

A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

(2008) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cytidine Deaminase APOBEC3H Restricts HIV-1 Replication

(2008) Ying Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins

(2008) R. S. LaRue et al.   JOURNAL OF VIROLOGY

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

(2008) Lauren G. Holden et al.   NATURE

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE