A Super-Resolved View of the Alzheimer’s Disease-Related Amyloidogenic Pathway in Hippocampal Neurons

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

(2021) Yang Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid-beta mediates homeostatic synaptic plasticity

(2021) Christos Galanis et al.   JOURNAL OF NEUROSCIENCE

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer’s Disease Pathology

(2020) Sophia Schedin-Weiss et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional cycle of EEA1-positive early endosome: Direct evidence for pre-existing compartment of degradative pathway

(2020) Rimma Kamentseva et al.   PLoS One

Stimulation-induced differential redistributions of clathrin and clathrin-coated vesicles in axons compared to soma/dendrites

(2020) Jung-Hwa Tao-Cheng   Molecular Brain

Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

(2020) Sabrina Simoes et al.   Science Translational Medicine

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

APP depletion alters selective pre- and post-synaptic proteins

(2019) Isak Martinsson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms

(2019) Natali L. Chanaday et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production

(2018) Cláudia Guimas Almeida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

High resolution approaches for the identification of amyloid fragments in brain

(2018) J.A. Ross et al.   JOURNAL OF NEUROSCIENCE METHODS

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

(2018) Gaël Barthet et al.   Nature Communications

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene

(2017) Håkan Thonberg et al.   Acta Neuropathologica Communications

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

(2016) Sophia Schedin-Weiss et al.   Acta Neuropathologica Communications

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

(2015) Per Nilsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

(2015) Joel Raskin et al.   Current Alzheimer Research

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner

(2014) Leonhard Möckl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Neuron-to-Neuron Transmission of Neurodegenerative Pathology

(2013) Martin Hallbeck et al.   NEUROSCIENTIST

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

(2012) Akhil Bhalla et al.   NEUROBIOLOGY OF DISEASE

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Fast, three-dimensional super-resolution imaging of live cells

(2011) Sara A Jones et al.   NATURE METHODS

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

(2011) Silke Brunholz et al.   EXPERIMENTAL BRAIN RESEARCH

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

(2010) Masakazu Hashimoto et al.   ACTA NEUROPATHOLOGICA

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

Amyloid β-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimerʼs brain

(2010) Mikio Aoki et al.   NEUROREPORT

Primary support cultures of hippocampal and substantia nigra neurons

(2009) Thomas Fath et al.   Nature Protocols

Intramembrane Proteolysis by γ-Secretase

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY