Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation

The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies

(2021) Jing Wang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling

(2021) Qian Ren et al.   PHYTOMEDICINE

Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota

(2020) Jiaojiao Han et al.   FASEB JOURNAL

The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

(2020) Xiu Liu et al.   PeerJ

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

(2020) Xifan Wang et al.   GUT

“Kidney Tea” and Its Bioactive Secondary Metabolites for Treatment of Gout

(2020) Wei-Di Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Allopurinol on the Progression of Chronic Kidney Disease

(2020) Sunil V. Badve et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Metabolomics Reveal the Role of AHR/GPR35 Mediated Kynurenic acid Gradient Sensing in Chemotherapy-induced Intestinal Damage

(2020) Di Wang et al.   Acta Pharmaceutica Sinica B

Amino Acid Metabolites Associated with Chronic Kidney Disease: An Eight-Year Follow-Up Korean Epidemiology Study

(2020) Hansongyi Lee et al.   Biomedicines

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson’s Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis

(2020) Yuanhui Zhu et al.   ACS Chemical Neuroscience

Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

(2020) Jing-Ru Liu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice

(2020) Jing Pan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson’s Disease

(2020) Tian-Jiao Chen et al.   Frontiers in Neuroscience

Serum Uric Acid-Lowering Effects of Combined Glycine and Tryptophan Treatments in Subjects with Mild Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

(2019) Shunji Oshima et al.   Nutrients

The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD

(2019) Yuka Sato et al.   Nature Reviews Nephrology

New Perspectives for Fisetin

(2019) Grzegorz Grynkiewicz et al.   Frontiers in Chemistry

Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia

(2019) Libin Pan et al.   Acta Pharmaceutica Sinica B

The physiology of uric acid and the impact of end-stage kidney disease and dialysis

(2018) Mariana Murea et al.   SEMINARS IN DIALYSIS

Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage

(2018) Fernando E. García-Arroyo et al.   PLoS One

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

(2018) Yiran Yu et al.   Frontiers in Microbiology

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis

(2018) Haina Wang et al.   NUTRITION

Comparative effectiveness of allopurinol, febuxostat and benzbromarone on renal function in chronic kidney disease patients with hyperuricemia: a 13-year inception cohort study

(2017) Hsu-Wen Chou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Simultaneous Quantification of Amino Metabolites in Multiple Metabolic Pathways Using Ultra-High Performance Liquid Chromatography with Tandem-mass Spectrometry

(2017) Jin Wang et al.   Scientific Reports

Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts

(2016) Malihe-Sadat Poormasjedi-Meibod et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gout

(2016) Nicola Dalbeth et al.   LANCET

Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine

(2016) N. Yamada et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study

(2016) Naama Karu et al.   BMC Nephrology

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

(2016) Zhuang Guo et al.   Scientific Reports

Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice

(2015) Yu-Tang Tung et al.   BMC Complementary and Alternative Medicine

EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy

(2015) N. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Helicobacter pyloriand serum kynurenine-tryptophan ratio in patients with colorectal cancer

(2015) Ayse Basak Engin   WORLD JOURNAL OF GASTROENTEROLOGY

Ligand Binding and Functional Selectivity of l-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR)

(2014) Roberto Nuti et al.   Journal of Chemical Information and Modeling

Altered tryptophan metabolism and CKD-associated fatigue

(2014) Henricus A.M. Mutsaers et al.   KIDNEY INTERNATIONAL

Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study

(2014) J. Jing et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

(2014) Marion Sallée et al.   Toxins

Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)

(2013) Anita C.A. Dankers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Plasma and Urinary Amino Acid Metabolomic Profiling in Patients with Different Levels of Kidney Function

(2013) F. Duranton et al.   Clinical Journal of the American Society of Nephrology

Role of Host Xanthine Oxidase in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli

(2013) John K. Crane et al.   INFECTION AND IMMUNITY

Uric acid and chronic kidney disease: which is chasing which?

(2013) R. J. Johnson et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms

(2009) J. C. Schefold et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION