The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

(2013) Amos A. Fatokun et al.   AMINO ACIDS

The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions

(2013) Karl Walter Bock   BIOLOGICAL CHEMISTRY

Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease

(2013) Shunsuke Ito et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats

(2013) Maimaiti Yisireyili et al.   LIFE SCIENCES

Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor

(2013) J. H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators

(2013) Michal L Melamed et al.   BMC Nephrology

Relation of Plasma Indoxyl Sulfate Levels and Estimated Glomerular Filtration Rate to Left Ventricular Diastolic Dysfunction

(2012) Bummei Sato et al.   AMERICAN JOURNAL OF CARDIOLOGY

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

(2012) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress

(2012) Gulinuer Muteliefu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation

(2012) Guofeng Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production

(2012) Yoshiharu Itoh et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The role of protein-bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis

(2012) Cheng-Jui Lin et al.   ATHEROSCLEROSIS

Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor

(2012) Vipul C. Chitalia et al.   CIRCULATION

Activation of Aryl Hydrocarbon Receptor Mediates Indoxyl Sulfate-Induced Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells

(2012) Ippei Watanabe et al.   CIRCULATION JOURNAL

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uremic solutes from colon microbes

(2012) Timothy W. Meyer et al.   KIDNEY INTERNATIONAL

Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry

(2011) Wentao Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Activation of Aryl Hydrocarbon Receptor Induces Vascular Inflammation and Promotes Atherosclerosis in Apolipoprotein E−/− Mice

(2011) Dalei Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation

(2011) Sourabh Kharait et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly

(2011) P. Monica Lind et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism

(2011) Yu-Sen Peng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Colonic Contribution to Uremic Solutes

(2011) P. A. Aronov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lack of modulatory effect of simvastatin on indoxyl sulfate-induced activation of cultured endothelial cells

(2011) Chien-Te Lee et al.   LIFE SCIENCES

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice

(2011) Suguru Yamamoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Vascular Incompetence in Dialysis Patients-Protein-Bound Uremic Toxins and Endothelial Dysfunction

(2011) Noémie Jourde-Chiche et al.   SEMINARS IN DIALYSIS

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells

(2011) Helén Andersson et al.   TOXICOLOGY

Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice

(2011) Violeta Arsenescu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

(2010) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-κB Pathway

(2010) Natsumi Masai et al.   CIRCULATION JOURNAL

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

(2010) S. Lekawanvijit et al.   EUROPEAN HEART JOURNAL

Relationship between an increased serum kynurenine/tryptophan ratio and atherosclerotic parameters in hemodialysis patients

(2010) Akihiko KATO et al.   Hemodialysis International

Indoxyl Sulfate Induces Leukocyte-Endothelial Interactions through Up-regulation of E-selectin

(2010) Shunsuke Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

(2010) Anna K. Kopec et al.   TOXICOLOGICAL SCIENCES

Cytochrome P4501A1 Is Required for Vascular Dysfunction and Hypertension Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

(2010) Phillip G. Kopf et al.   TOXICOLOGICAL SCIENCES

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice

(2010) Sung Gu Han et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1

(2010) P.G. Kopf et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls

(2010) Zuzana Majkova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ROS and PDFG-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

(2009) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Aryl-hydrocarbon receptor-dependent alteration of FAK/RhoA in the inhibition of HUVEC motility by 3-methylcholanthrene

(2009) Chih-Cheng Chang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs

(2009) Yean Jung Choi et al.   ENVIRONMENT INTERNATIONAL

Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy

(2009) Tamehachi Namikoshi et al.   HYPERTENSION RESEARCH

Indoxyl Sulfate Promotes Proliferation of Human Aortic Smooth Muscle Cells by Inducing Oxidative Stress

(2009) Gulinuer Muteliefu et al.   JOURNAL OF RENAL NUTRITION

Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients

(2009) N JOURDE-CHICHE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

(2009) H. Fujii et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms

(2009) J. C. Schefold et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease

(2009) Krystyna Pawlak et al.   THROMBOSIS RESEARCH

Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent

(2009) Zuzana Majkova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease

(2008) Krystyna Pawlak et al.   ATHEROSCLEROSIS

The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects

(2008) Fumio Matsumura   BIOCHEMICAL PHARMACOLOGY

Significance of the Nongenomic, Inflammatory Pathway in Mediating the Toxic Action of TCDD To Induce Rapid and Long-Term Cellular Responses in 3T3-L1 Adipocytes†

(2008) Wen Li et al.   BIOCHEMISTRY

Hypertension, Cardiac Hypertrophy, and Impaired Vascular Relaxation Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin are Associated with Increased Superoxide

(2008) Phillip G. Kopf et al.   Cardiovascular Toxicology

Dioxins and Cardiovascular Disease Mortality

(2008) Olivier Humblet et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Association of polychlorinated biphenyls with hypertension in the 1999–2002 National Health and Nutrition Examination Survey

(2008) Charles J. Everett et al.   ENVIRONMENTAL RESEARCH

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3‐dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study

(2008) P. Niinisalo et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway

(2008) Elizabeth Oesterling et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells

(2008) Dan Meng et al.   TOXICOLOGY LETTERS