Article
Pharmacology & Pharmacy
Yanrong Ma, Fenglin Ran, Mingyan Xin, Xueyan Gou, Xinyi Wang, Xinan Wu
Summary: In this study, albumin-bound kynurenic acid was identified as an endogenous biomarker for the renal tubular OATs-MRP4 channel. It can be used to adjust the dosage of drugs secreted by this channel or predict kidney injury.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Nan Fan, Yun Yu, Lvyu Li, Heng Xia, Xiangxian Dong, Yongkun Li, Huan Chen, Weigang Duan
Summary: Uricase-deficient rats exhibit growth retardation, increased urine excretion, altered organ indexes, elevated serum uric acid levels, and mild organ injuries compared to wild-type rats, suggesting a different biological pattern and potential renal and hepatic damage caused by uricase deficiency.
Review
Biochemistry & Molecular Biology
Robert Eckenstaler, Ralf A. Benndorf
Summary: Urate homeostasis in humans is a complex and highly heritable process that involves metabolic urate biosynthesis, renal urate reabsorption, and renal and extrarenal urate excretion. ABCG2 plays a crucial role in urate transport and is associated with early-onset gout.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Layla Nabai, Aziz Ghahary, John Jackson
Summary: Excessive fibrosis following surgical procedures is a challenging condition with no effective preventive or therapeutic option. The use of a controlled release drug delivery system loaded with kynurenic acid (KynA) has been shown to effectively prevent fibrosis in closed wounds. In vitro and in vivo experiments demonstrated that KynA microspheres effectively reduced collagen deposition and alpha-smooth muscle actin expression, suggesting a novel therapeutic option for the prevention or treatment of post-surgical fibrosis.
Article
Biochemistry & Molecular Biology
Isaac Rodriguez-Rovira, Angela Lopez-Sainz, Maria Encarnacion Palomo-Buitrago, Belen Perez, Francesc Jimenez-Altayo, Victoria Campuzano, Gustavo Egea
Summary: Redox stress is involved in the pathogenesis of aortic aneurysm in Marfan syndrome. Allopurinol, a xanthine oxidoreductase inhibitor, acts as an antioxidant without changing uric acid levels and can block aortopathy in a MFS mouse model. This study aimed to evaluate the impact of hyperuricaemia on aortopathy pathogenesis in MFS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
W. Kedzierski, I Sadok, S. Kowalik, I Janczarek, M. Staniszewska
Summary: This study evaluated the effects of two different types of exercise (short-time intense exercise and endurance exercise) on tryptophan metabolism in horses of the same breed. The results showed that both types of exercise led to an increase in tryptophan metabolites, especially kynurenic acid, which had beneficial effects on the mental state of the horses.
Review
Immunology
Ana Elisa Del'Arco, Deivison Silva Argolo, Gilles Guillemin, Maria de Fatima Dias Costa, Silvia Lima Costa, Alexandre Moraes Pinheiro
Summary: Neuroinflammation is a common feature in neurological disorders and can be both neuroprotective and neurotoxic. The kynurenine pathway, involved in immune regulation, neuroprotection, and neurotoxicity, is frequently activated during neuroinflammation. Studying the kynurenine pathway in the context of Neospora caninum infection can provide insights into its role in the neuroinflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ching Lo, Chih-Lung Lin, Wei-Yu Fang, Balint Lorinczi, Istvan Szatmari, Wan-Hsuan Chang, Ferenc Fulop, Sheng-Nan Wu
Summary: Kynurenic acid and its derivative have modulatory effects on M-type K+ currents in pituitary cells and hippocampal neurons, while also exerting mild effects on other ionic currents. This may be one mechanism through which they modulate excitability in cells in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Patrycja Ziuzia, Zuzanna Janiec, Magdalena Wrobel-Kwiatkowska, Zbigniew Lazar, Magdalena Rakicka-Pustulka
Summary: This study isolated and identified 15 yeast strains from lime honey samples in Poland and evaluated their ability to biosynthesize value-added chemicals. The results showed that a strain called Y. lipolytica No. 12 could grow on fructose and produce 3.9 mg/L of kynurenic acid. This study highlights the potential of honey as a source of wild-type yeasts with valuable production properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Omar Taleb, Mohammed Maammar, Christian Klein, Michel Maitre, Ayikoe Guy Mensah-Nyagan
Summary: Xanthurenic acid (XA) is a metabolite of the kynurenine pathway synthesized in the brain from dietary or microbial tryptophan, suspected to modulate some pathophysiological mechanisms of neuropsychiatric and/or neurodegenerative diseases. Studies have shown that XA may play an important role in the endocrine system and could affect normal dopaminergic activity in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
J. Matthew Hinkley, Gong Xin Yu, Robert A. Standley, Giovanna Distefano, Vladimir Tolstikov, Niven R. Narain, Bennett P. Greenwood, Shraddha Karmacharya, Michael A. Kiebish, Elvis Alvarez Carnero, Fanchao Yi, Rick B. Vega, Bret H. Goodpaster, Stephen J. Gardell, Paul M. Coen
Summary: Age and physical activity have different effects on muscle metabolites, with higher levels of kynurenine metabolites in older adults' muscles and higher levels of kynurenic acid and NAD(+) metabolites in active adults' muscles, which are associated with cardiorespiratory fitness and muscle oxidative capacity. Additionally, elevated levels of acylcarnitines in muscles of physically active individuals may indicate impaired metabolic health. Surprisingly, acute endurance exercise induces similar changes in whole-body substrate utilization, muscle acylcarnitines, and ketone bodies, regardless of activity levels.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Biochemistry & Molecular Biology
Ping Chen, Xiaofei Geng
Summary: Parkinson's disease (PD) is characterized by the death of dopamine (DA) neurons and the accumulation of α-synuclein fibrils in the substantia nigra pars compacta (SNpc), along with central nervous system inflammation. Elevated levels of central inflammatory factors disrupt the kynurenine pathway (KP) in PD, leading to reduced neuroprotective metabolite KYNA and increased neurotoxic metabolite QUIN, exacerbating excitotoxicity and inflammation. KYNA analogs, precursor drugs, and KP enzyme modulators may offer potential therapeutic strategies for PD.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
William O. Jonsson, Jonathan Ponette, Oscar Horwath, Tomas Rydenstam, Karin Soderlund, Bjorn Ekblom, Michele Azzolini, Jorge L. Ruas, Eva Blomstrand
Summary: Administration of BCAA can enhance mitochondrial biogenesis and lower plasma levels of aromatic amino acids, kynurenine, and kynurenic acid. However, BCAA did not affect muscle kynurenine levels, suggesting that kynurenine metabolism was altered in tissues other than muscle.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Adrian Matencio, Fabrizio Caldera, Alberto Rubin Pedrazzo, Yousef Khazaei Monfared, Nilesh K. Dhakar, Francesco Trotta
Summary: In this study, the interaction between Kynurenic acid (KYNA) and various cyclodextrins (CDs) was investigated, with HP beta-CD demonstrating the strongest complexation constant. The formation of inclusion complexes was found to be influenced by pH and temperature, with thermodynamic parameters and molecular docking calculations providing insights into the complexation mechanism.
Article
Agriculture, Multidisciplinary
Longjun Shu, Meifeng Yang, Naixin Liu, Yixiang Liu, Huiling Sun, Siyu Wang, Yue Zhang, Yilin Li, Xinwang Yang, Ying Wang
Summary: This study optimized a plant-derived peptide RDP1-M3 for anti-hyperuricemia, showing enhanced efficacy in alleviating hyperuricemia and inhibiting XOD in mice, as well as influencing the expression of various proteins related to uric acid metabolism in vivo.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Transplantation
Mendy ter Avest, Romy N. Bouwmeester, Caroline Duineveld, Kioa L. Wijnsma, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, David M. Burger, Jack F. M. Wetzels, Nicole C. A. J. van de Kar, Rob ter Heine
Summary: This study evaluated the pharmacokinetics and pharmacodynamics of eculizumab in patients with atypical haemolytic uraemic syndrome (aHUS) and proposed improved dosing strategies. The study found that individualized dosing strategy could improve treatment response and reduce treatment costs by prolonging the dosing interval.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Rosa Vargas-Poussou, Felix Claverie-Martin, Caroline Prot-Bertoye, Valentina Carotti, Jenny van der Wijst, Ana Perdomo-Ramirez, Gloria M. Fraga-Rodriguez, Marguerite Hureaux, Caro Bos, Femke Latta, Pascal Houillier, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Summary: This study identifies TRPM7 as a potential candidate gene for hereditary HSH, and the mutations in TRPM7 gene result in impaired magnesium transport, leading to hypomagnesaemia and secondary hypocalcaemia.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Pediatrics
Tjessa Bondue, Lambertus van den Heuvel, Elena Levtchenko, Roland Brock
Summary: Inherited kidney diseases affect different nephron segments and can lead to kidney failure. Advances in genetic testing have increased our understanding of the molecular basis and pathophysiology of these diseases, revealing new potential therapeutic targets. RNA-based therapies, which have revolutionized molecular therapy, are now emerging in the field of kidney diseases.
PEDIATRIC NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lotte E. E. Tholen, Heidi Schigt, Sanne G. E. Kleuskens, Caro Bos, Cornelia G. G. Spruijt, Brigith Willemsen, Michiel Vermeulen, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Summary: We identified BAIAP2L2 as a novel transcriptional target of HNF1 beta, which plays a role in maintaining epithelial cell integrity in the kidney.
Article
Multidisciplinary Sciences
Fjodor A. Yousef Yengej, Jitske Jansen, Carola M. E. Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G. Hoenderop, Bart Smeets, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers
Summary: Kidney organoids derived from induced pluripotent stem cells (iPSC) have limited expansion capacity and immaturity, hindering specific applications. In this study, the newly developed tubuloid protocols are used to purify and propagate kidney epithelium from d7+18 iPSC-derived organoids, generating iPSC organoid-derived (iPSCod) tubuloids. These tubuloids can be exponentially expanded for at least 2.5 months while maintaining important tubular transporter expression. They provide easy apical access and enable functional evaluation of secretion and electrolyte reabsorption processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Urology & Nephrology
David Loureiro Ramada, Joost de Vries, Jeroen Vollenbroek, Nazia Noor, Odyl ter Beek, Silvia M. M. Mihaila, Fokko Wieringa, Rosalinde Masereeuw, Karin Gerritsen, Dimitrios Stamatialis
Summary: Haemodialysis is expensive and has limitations in removing uraemic solutes, causing poor patient quality of life and large carbon footprint. Innovative dialysis technologies, such as portable, wearable and implantable artificial kidney systems, are being developed to address these issues. Challenges include the need for continuous regeneration of dialysate and improving toxin removal. Efforts to overcome these challenges include developing dialysate recycling systems and novel membranes combined with bioartificial kidneys.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Food Science & Technology
Yi Yang, Milos Mihajlovic, Manoe J. Janssen, Rosalinde Masereeuw
Summary: This study investigated the role of uremic toxin indoxyl sulfate (IS) in accelerating cellular senescence and promoting kidney fibrosis. The findings suggest that IS accelerates senescence in proximal tubule epithelial cells through TNF-alpha and NF-kappa B signaling early on, and the epithelial-mesenchymal transition process at later time points.
Article
Oncology
Christoph Thomssen, Martina Vetter, Eva J. J. Kantelhardt, Christoph Meisner, Marcus Schmidt, Pierre M. M. Martin, Florian Clatot, Doris Augustin, Volker Hanf, Daniela Paepke, Wolfgang Meinerz, Gerald Hoffmann, Wolfgang Wiest, Fred C. G. J. Sweep, Manfred Schmitt, Fritz Jaenicke, Sibylle Loibl, Gunter von Minckwitz, Nadia Harbeck
Summary: The NNBC-3 Europe trial aimed to assess the risk of recurrence in node-negative breast cancer patients and to determine whether taxanes can improve disease-free survival in high-risk patients. The study found that patients with high-risk node-negative breast cancer have a favorable prognosis in the first few years after diagnosis regardless of the type of chemotherapy.
Review
Biochemistry & Molecular Biology
Sabbir Ahmed, Joost C. de Vries, Jingyi Lu, Milan H. Verrijn Stuart, Silvia M. Mihaila, Robin W. M. Vernooij, Rosalinde Masereeuw, Karin G. F. Gerritsen
Summary: Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. Conventional dialysis techniques are not efficient in removing PBUTs due to their plasma protein binding. Therefore, novel approaches are being developed and validated in animal models before clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Joao Faria, Sabbir Ahmed, Dimitrios Stamatialis, Marianne C. Verhaar, Rosalinde Masereeuw, Karin G. F. Gerritsen, Silvia M. Mihaila
Summary: Patients with end-stage kidney disease suffer from high levels of protein-bound uremic toxins. Conventional dialysis methods are ineffective in removing these toxins. A potential solution could be a bioartificial kidney composed of membranes with proximal tubule epithelial cells that actively secrete these toxins. However, the development of this bioartificial kidney is hampered by a lack of knowledge regarding the cytocompatibility of the dialysis fluid. This study shows that the dialysis fluid does not affect the viability or function of the cells, and efficiently clears the toxins from the perfusion fluid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Lotte E. Tholen, Femke Latta, Joost H. A. Martens, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Summary: Mutations in the HNF18 gene cause a rare and heterogeneous disease characterized by renal cysts, diabetes, and electrolyte disturbances. This study identified new targets of HNF18 that are involved in cell polarity pathways. Functional experiments showed that mutant Hnf1b cells had decreased tight junction integrity and altered cell morphology. These findings highlight the importance of HNF18 in regulating tight junction integrity and cell structure in the distal part of the nephron.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Letter
Medicine, Research & Experimental
Henricus A. M. Mutsaers, Camilla Merrild, Rikke Norregaard, Oleguer Plana-Ripoll
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cornelis J. Slingerland, Vladyslav Lysenko, Samhita Chaudhuri, Charlotte M. J. Wesseling, Devon Barnes, Rosalinde Masereeuw, Nathaniel I. Martin
Summary: A study found that novel semisynthetic polymyxins have reduced toxicity and exhibit synergistic effects against polymyxin-resistant bacteria.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Lara W. Zeper, Edward R. Smith, Anique D. ter Braake, Paul T. Tinnemans, Jeroen H. F. de Baaij, Joost G. J. Hoenderop
Summary: Circulating calciprotein particles (CPP) have been identified as potential drivers of the calcification process in chronic kidney disease. This study compared CPP produced using different protocols in terms of particle morphology, composition, particle number, and in vitro calcification potency. The results showed that the composition of CPP and the method of quantification play a role in determining their calcification potency, and synthetic CPP are not comparable to endogenous CPP in terms of calcification propensity.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)