Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice

Molecular Probe Crossing Blood–Brain Barrier for Bimodal Imaging–Guided Photothermal/Photodynamic Therapies of Intracranial Glioblastoma

(2020) Bo Li et al.   ADVANCED FUNCTIONAL MATERIALS

Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma

(2020) Zheyu Shen et al.   BIOMATERIALS

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review

(2020) Michael Fana et al.   International Journal of Nanomedicine

Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma

(2020) Hiroaki Kinoh et al.   ACS Nano

Design and validation of liposomal ApoE2 gene delivery system to evade blood-brain barrier for effective treatment of Alzheimer’s disease

(2020) Sanjay Arora et al.   MOLECULAR PHARMACEUTICS

Transferrin Receptor-Targeted PEG-PLA Polymeric Micelles for Chemotherapy Against Glioblastoma Multiforme

(2020) Ping Sun et al.   International Journal of Nanomedicine

Brain delivery of Plk1 inhibitor via chimaeric polypeptide polymersomes for safe and superb treatment of orthotopic glioblastoma

(2020) Qianyi Fan et al.   JOURNAL OF CONTROLLED RELEASE

Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation

(2020) Wenxing Gu et al.   JOURNAL OF CONTROLLED RELEASE

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09): a randomised, open-label, phase 3 trial

(2019) Ulrich Herrlinger et al.   LANCET

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

(2019) Rui Pedro Moura et al.   Expert Opinion on Drug Delivery

Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice

(2019) Huazhen Qin et al.   MOLECULAR PHARMACEUTICS

Systematic Evaluation of Transferrin-Modified Porous Silicon Nanoparticles for Targeted Delivery of Doxorubicin to Glioblastoma

(2019) Meihua Luo et al.   ACS Applied Materials & Interfaces

CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo

(2019) Huimin Fang et al.   BIOMACROMOLECULES

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

(2019) Sushant Lakkadwala et al.   JOURNAL OF CONTROLLED RELEASE

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

(2019) Jinbing Xie et al.   BIOMATERIALS

Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

(2019) Gyeungyun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma

(2018) Kelong Fan et al.   ACS Nano

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Protein Toxin Chaperoned by LRP-1-Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo

(2018) Yu Jiang et al.   ADVANCED MATERIALS

Transferrin-targeted, resveratrol-loaded liposomes for the treatment of glioblastoma

(2018) Aditi Jhaveri et al.   JOURNAL OF CONTROLLED RELEASE

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

(2018) Lakshmi Pallavi Ganipineni et al.   JOURNAL OF CONTROLLED RELEASE

Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy

(2018) Pengfei Zhao et al.   Chemical Science

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

(2018) Xiaoyue Chen et al.   Nature Communications

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

(2018) Yu Jiang et al.   ACS Nano

Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine

(2018) Yan Zou et al.   ADVANCED MATERIALS

Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes

(2018) Yanan Shi et al.   JOURNAL OF CONTROLLED RELEASE

C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs

(2018) Kiat Hwa Chan et al.   Scientific Reports

ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier

(2017) R. Dal Magro et al.   JOURNAL OF CONTROLLED RELEASE

ATN-161 Peptide Functionalized Reversibly Cross-Linked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice

(2017) Ning Zhang et al.   MOLECULAR PHARMACEUTICS

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

(2017) James R. Perry et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

(2016) Tingting Lin et al.   ACS Nano

Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

(2016) Benjamí Oller-Salvia et al.   CHEMICAL SOCIETY REVIEWS

A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment

(2016) Shiqian Gao et al.   JOURNAL OF CONTROLLED RELEASE

Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx?

(2016) Yan Zou et al.   JOURNAL OF CONTROLLED RELEASE

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

(2016) Brigitta G Baumert et al.   LANCET ONCOLOGY

Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma

(2016) Aniket S. Wadajkar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

New Strategies in Glioblastoma: Exploiting the New Biology

(2015) H. A. Fine   CLINICAL CANCER RESEARCH

Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts

(2015) Yinan Zhong et al.   JOURNAL OF CONTROLLED RELEASE

Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy

(2015) Ru Cheng et al.   Nano Today

Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy

(2013) Shixian Lv et al.   Acta Biomaterialia

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

(2012) Jian Chen et al.   CELL

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Clinical impact of serum proteins on drug delivery

(2011) Felix Kratz et al.   JOURNAL OF CONTROLLED RELEASE

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

(2011) R. Kurzrock et al.   MOLECULAR CANCER THERAPEUTICS

Temozolomide: therapeutic limitations in the treatment of adult high-grade gliomas

(2010) Marc C Chamberlain   Expert Review of Neurotherapeutics

Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain

(2010) Inge van Rooy et al.   JOURNAL OF CONTROLLED RELEASE