Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

Smart Responsive Quercetin-Conjugated Glycol Chitosan Prodrug Micelles for Treatment of Inflammatory Bowel Diseases

(2021) Cuiyun Shen et al.   MOLECULAR PHARMACEUTICS

Personalized Medicine of Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacogenetics, Therapeutic Drug Monitoring, and Beyond

(2021) Antonello Di Paolo et al.   Frontiers in Pharmacology

Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease

(2021) Liucan Wang et al.   Journal of Inflammation Research

Host engulfment pathway controls inflammation in inflammatory bowel disease

(2020) Ibrahim M. Sayed et al.   FEBS Journal

Controlled release of sulfasalazine loaded amidated pectin microparticles through Eudragit S 100 coated capsule for management of inflammatory bowel disease

(2020) Rohitas Deshmukh et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Nanoparticles Derived from the Natural Antioxidant Rosmarinic Acid Ameliorate Acute Inflammatory Bowel Disease

(2020) Chan Ho Chung et al.   ACS Nano

Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease

(2020) Minakshi Prasad et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells

(2020) Zhengguo Zhang et al.   Cancers

Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease

(2020) Tripti Khare et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

(2020) Chunhua Yang et al.   JOURNAL OF CONTROLLED RELEASE

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

(2020) Bruno Lamas et al.   Particle and Fibre Toxicology

Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity

(2020) Jian-Guo Gao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease

(2020) Xin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Mesopore to Macropore Transformation of Metal–Organic Framework for Drug Delivery in Inflammatory Bowel Disease

(2020) Yi Yin et al.   Advanced Healthcare Materials

Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy

(2020) Eden Mariam Jacob et al.   Nanomaterials

Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

(2020) Peng Liu et al.   Acta Pharmaceutica Sinica B

Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors

(2019) Yanzuo Chen et al.   ACS Nano

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-based Data

(2019) Stephanie Coward et al.   GASTROENTEROLOGY

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release

(2019) Nieves Iglesias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals

(2019) Panna Vass et al.   JOURNAL OF CONTROLLED RELEASE

Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

(2019) Xin Xu et al.   Nano Research

Infliximab in inflammatory bowel disease

(2019) Konstantinos Papamichael et al.   Therapeutic Advances in Chronic Disease

Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease

(2019) Davide Di Fusco et al.   Frontiers in Pharmacology

The future of nanomedicine in optimising the treatment of inflammatory bowel disease

(2019) Lauren J. Mohan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Interfering with leukocyte trafficking in Crohn’s Disease

(2019) Sujata Biswas et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review

(2019) Maartje M. van de Meeberg et al.   DIGESTION

Real World Experience With Ustekinumab in Children and Young Adults at a Tertiary Care Pediatric Inflammatory Bowel Disease Center

(2019) Judy R. Dayan et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Can naturally occurring nanoparticle-based targeted drug delivery effectively treat inflammatory bowel disease?

(2019) Chunhua Yang et al.   Expert Opinion on Drug Delivery

Krill Oil-Incorporated Liposomes As An Effective Nanovehicle To Ameliorate The Inflammatory Responses Of DSS-Induced Colitis

(2019) Jin-Hee Kim et al.   International Journal of Nanomedicine

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

(2019) Qingdong Guan   Journal of Immunology Research

Self-Regulated Carboxyphenylboronic Acid-Modified Mesoporous Silica Nanoparticles with “Touch Switch” Releasing Property for Insulin Delivery

(2018) Lin Hou et al.   ACS Applied Materials & Interfaces

Nanocarrier-Mediated Chemo-Immuno Therapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma

(2018) Qi Liu et al.   ACS Nano

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

(2018) Niranjan G. Kotla et al.   ADVANCED DRUG DELIVERY REVIEWS

Review article: predictors of response to vedolizumab and ustekinumab in inflammatory bowel disease

(2018) A. Barré et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Enzyme-Responsive Charge-Reversal Polymer-Mediated Effective Gene Therapy for Intraperitoneal Tumors

(2018) Nasha Qiu et al.   BIOMACROMOLECULES

Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases

(2018) Qijuan Sun et al.   CARBOHYDRATE POLYMERS

Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease

(2018) Britt Christensen et al.   Clinical Gastroenterology and Hepatology

Study the effects of mesenchymal stem cell conditioned medium injection in mouse model of acute colitis

(2018) Sedigheh Pouya et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Preparation and release characteristics of mesalazine loaded calcium pectin-silica gel beads based on callus cultures pectins for colon-targeted drug delivery

(2018) Elena A. Günter et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease

(2018) Yilin Guo et al.   MOLECULES

Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease

(2018) Hai-Qin Ma et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Rhamnogalacturonan, a chemically-defined polysaccharide, improves intestinal barrier function in DSS-induced colitis in mice and human Caco-2 cells

(2018) Daniele Maria-Ferreira et al.   Scientific Reports

Emerging Therapies for Inflammatory Bowel Disease

(2018) Roni Weisshof et al.   ADVANCES IN THERAPY

Exosomes as a novel cell‐free therapeutic approach in gastrointestinal diseases

(2018) Kaveh Baghaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

JAK inhibition in inflammatory bowel disease

(2017) Pablo Olivera et al.   Expert Review of Clinical Immunology

Management Strategies to Improve Outcomes of Patients With Inflammatory Bowel Diseases

(2017) Jean-Frederic Colombel et al.   GASTROENTEROLOGY

Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics

(2017) Konstantinos H. Katsanos et al.   Gut and Liver

Predicting Hospitalization and Outpatient Corticosteroid Use in Inflammatory Bowel Disease Patients Using Machine Learning

(2017) Akbar K Waljee et al.   INFLAMMATORY BOWEL DISEASES

Trends in Narcotic and Corticosteroid Prescriptions in Patients with Inflammatory Bowel Disease in the United States Ambulatory Care Setting from 2003 to 2011

(2017) Neeraj Narula et al.   INFLAMMATORY BOWEL DISEASES

Modified apple polysaccharide prevents colitis through modulating IL-22 and IL-22BP expression

(2017) Yuhua Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of Non-Starch Polysaccharides on Inflammatory Bowel Disease

(2017) Ying Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease

(2017) L.C.S. De Vries et al.   Journal of Crohns & Colitis

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

(2017) Mingzhen Zhang et al.   Journal of Crohns & Colitis

Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier

(2017) Fredrik E.O. Holmberg et al.   Journal of Tissue Engineering and Regenerative Medicine

Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

(2017) Zhongbin Deng et al.   MOLECULAR THERAPY

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

(2017) Sufeng Zhang et al.   Nano Today

Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model

(2017) Chiara Dianzani et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease

(2017) Fei Mao et al.   Oncotarget

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

(2017) Fei Mao et al.   Biomed Research International

Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

(2017) Chenghui Zhu et al.   JOURNAL OF NANOBIOTECHNOLOGY

ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling

(2017) Jinquan Li et al.   Scientific Reports

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

(2016) Qixiong Zhang et al.   BIOMATERIALS

Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa

(2016) Seyed Yaser Vafaei et al.   CARBOHYDRATE POLYMERS

RNA interference-based nanosystems for inflammatory bowel disease therapy

(2016) Jian Guo et al.   International Journal of Nanomedicine

Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis

(2016) Qiang-Song Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mercaptopurine and inflammatory bowel disease: the other thiopurine

(2016) Fernando Bermejo San José et al.   REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

(2016) Abdul Muheem et al.   SAUDI PHARMACEUTICAL JOURNAL

Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

(2016) Yungang Wang et al.   Oncotarget

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions

(2016) Stephen M. Vindigni et al.   Therapeutic Advances in Gastroenterology

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Inflammatory Bowel Diseases (Crohn´s Disease and Ulcerative Colitis): Cost of Treatment in Serbia and the Implications

(2016) Marina Kostić et al.   Applied Health Economics and Health Policy

Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases

(2015) Meghna Talekar et al.   AAPS Journal

Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats

(2015) Ines Castangia et al.   Acta Biomaterialia

Inflammatory Bowel Disease: Pathogenesis, Causative Factors, Issues, Drug Treatment Strategies, and Delivery Approaches

(2015) Deependra Singh et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Size-dependent nanoparticulate drug delivery in inflammatory bowel diseases

(2015) John Youshia et al.   Expert Opinion on Drug Delivery

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

(2015) Susan Hua et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

The epidemiology of inflammatory bowel disease

(2015) Johan Burisch et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

(2015) Sufeng Zhang et al.   Science Translational Medicine

Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis

(2015) Jia Yang et al.   PLoS One

Bimodal Tumor-Targeting from Microenvironment Responsive Hyaluronan Layer-by-Layer (LbL) Nanoparticles

(2014) Erik C. Dreaden et al.   ACS Nano

Classical and recent advances in the treatment of inflammatory bowel diseases

(2014) H. Sales-Campos et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Therapeutic applications of hydrogels in oral drug delivery

(2014) Lindsey A Sharpe et al.   Expert Opinion on Drug Delivery

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Nanotechnology in the treatment of inflammatory bowel diseases

(2014) Angelo Viscido et al.   Journal of Crohns & Colitis

Intestinal barrier in inflammatory bowel disease

(2014) Lena Antoni   WORLD JOURNAL OF GASTROENTEROLOGY

Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticles

(2014) Bo Xiao et al.   Journal of Materials Chemistry B

Orally administered liposomal formulations for colon targeted drug delivery

(2014) Susan Hua   Frontiers in Pharmacology

Drug delivery strategies in the therapy of inflammatory bowel disease

(2013) Christian Lautenschläger et al.   ADVANCED DRUG DELIVERY REVIEWS

Meta-analysis using individual patient data: efficacy and durability of topical alicaforsen for the treatment of active ulcerative colitis

(2013) S. Vegter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease

(2013) Christian Lautenschläger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis

(2013) Ana Beloqui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The burden of inflammatory bowel disease in Europe

(2013) Johan Burisch et al.   Journal of Crohns & Colitis

Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles

(2013) Hamed Laroui et al.   MOLECULAR THERAPY

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

(2013) Baomei Wang et al.   MOLECULAR THERAPY

Dietary and commensal derived nutrients: shaping mucosal and systemic immunity

(2012) Sean P Spencer et al.   CURRENT OPINION IN IMMUNOLOGY

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

(2012) Bo Xiao et al.   Expert Opinion on Drug Delivery

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

(2012) Long Binh Vong et al.   GASTROENTEROLOGY

Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies

(2012) Régis Coco et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

(2012) Eva-Maria Collnot et al.   JOURNAL OF CONTROLLED RELEASE

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa—A first in vivo study in human patients

(2012) Carsten Schmidt et al.   JOURNAL OF CONTROLLED RELEASE

P351 Long term treatment with autologous red blood cells loaded with dexamethasone 21-phosphate in pediatric patients affected by steroid-dependent Crohn's disease: In the era of biologics can steroids be reconsidered?

(2012) B. Papadatou et al.   Journal of Crohns & Colitis

Targeting the leukocyte activation cascade: Getting to the site of inflammation using microfabricated assays

(2012) Enoch Kim et al.   LAB ON A CHIP

Potential prospects of nanomedicine for targeted therapeutics in inflammatory bowel diseases

(2012) Madharasi VA Pichai   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory bowel disease: is it a primary immunodeficiency?

(2011) Erik Glocker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

(2011) Hang Thi Thu Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual TNF-α/Cyclin D1 Gene Silencing With an Oral Polymeric Microparticle System as a Novel Strategy for the Treatment of Inflammatory Bowel Disease

(2011) Christina Kriegel et al.   Clinical and Translational Gastroenterology

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(d,l-lactide-co-glycolide) nanospheres for inflammatory bowel disease

(2010) Kohei Tahara et al.   BIOMATERIALS

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

(2010) Christina Kriegel et al.   JOURNAL OF CONTROLLED RELEASE

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Human erythrocytes as nanoparticle carriers for magnetic particle imaging

(2010) D E Markov et al.   PHYSICS IN MEDICINE AND BIOLOGY

pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model

(2009) Abdallah Makhlof et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

(2009) Hamed Laroui et al.   GASTROENTEROLOGY

Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease

(2008) M D Bhavsar et al.   GENE THERAPY

Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer

(2008) Robert S. Chapkin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY