Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity

GLP-1 regulation by food proteins and protein hydrolysates

(2021) Alba Miguéns-Gómez et al.   NUTRITION RESEARCH REVIEWS

Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

(2021) Ida Marie Modvig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Combination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet

(2021) Aphichat Trakooncharoenvit et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavone Hispidulin Stimulates Glucagon‐Like Peptide‐1 Secretion and Ameliorates Hyperglycemia in Streptozotocin‐Induced Diabetic Mice

(2020) Yao Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Induction of CCK and GLP-1 release in enteroendocrine cells by egg white peptides generated during gastrointestinal digestion

(2020) Marta Santos-Hernández et al.   FOOD CHEMISTRY

Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell lines

(2020) Takumi Nakamura et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein

(2020) Nanjaiah Lalitha et al.   PLoS One

Apigenin modulates hippocampal CREB-BDNF signaling in high fat, high fructose diet-fed rats

(2020) Jagan Kalivarathan et al.   Journal of Functional Foods

GLP-1 response to whey protein is less diminished by DPP-4 in comparison to responses to dextrin, a lipid, and casein in rats

(2020) Yuki Shimizu et al.   BRITISH JOURNAL OF NUTRITION

Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus

(2020) Carolyn F. Deacon   Nature Reviews Endocrinology

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

(2020) Ahsan Hameed et al.   Nutrients

GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art

(2020) Michael A. Nauck et al.   Molecular Metabolism

The Clinical Application of Mealtime Whey Protein for the Treatment of Postprandial Hyperglycaemia for People With Type 2 Diabetes: A Long Whey to Go

(2020) Kieran Smith et al.   Frontiers in Nutrition

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

(2020) Sandy Theysgeur et al.   MOLECULES

Continuous feeding with a combined high fat/high sucrose diet, rather than an individual high fat or high sucrose diet, rapidly enhances the GLP-1 secretory response to meal ingestion in diet-induced obese rats

(2019) Jukkrapong Pinyo et al.   NUTRITION

Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

(2019) Carolyn F. Deacon   Frontiers in Endocrinology

Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo

(2019) Rashmi Rajappa et al.   Frontiers in Pharmacology

Quercetin and its metabolite isorhamnetin promote glucose uptake through different signalling pathways in myotubes

(2019) Hao Jiang et al.   Scientific Reports

INFOGEST static in vitro simulation of gastrointestinal food digestion

(2019) André Brodkorb et al.   Nature Protocols

Genistein enhances the secretion of glucagon-like peptide-1 (GLP-1) via downregulation of inflammatory responses

(2019) Kanwal Rehman et al.   BIOMEDICINE & PHARMACOTHERAPY

Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type-2 diabetes mellitus

(2019) Hassan Braxas et al.   Canadian Journal of Diabetes

Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats

(2019) Aphichat Trakooncharoenvit et al.   EUROPEAN JOURNAL OF NUTRITION

Hidden “Digestome”: Current Analytical Approaches Provide Incomplete Peptide Inventories of Food Digests

(2019) Maristella De Cicco et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats

(2019) Jukkrapong Pinyo et al.   BRITISH JOURNAL OF NUTRITION

Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

(2019) Shital P. Patil et al.   International Journal of Peptide Research and Therapeutics

The incretin system in healthy humans: The role of GIP and GLP-1

(2019) Jens Juul Holst   METABOLISM-CLINICAL AND EXPERIMENTAL

Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

(2019) Sundaram R et al.   TOXICOLOGY MECHANISMS AND METHODS

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

What Is GLP-1 Really Doing in Obesity?

(2019) Tohru Hira et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

(2018) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats

(2018) Masaki Hayakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice

(2018) Hana Alkhalidy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

(2018) Yusaku Iwasaki et al.   Nature Communications

Hypoglycemic effect and mechanism of isoquercitrin as an inhibitor of dipeptidyl peptidase-4 in type 2 diabetic mice

(2018) Lei Zhang et al.   RSC Advances

(–)-Epicatechin in the control of glucose homeostasis: Involvement of redox-regulated mechanisms

(2018) Eleonora Cremonini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diversity of enteroendocrine cells investigated at cellular and subcellular levels: the need for a new classification scheme

(2018) Linda J. Fothergill et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake

(2018) Ogooluwa A. Ojelabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

(2018) Stephen T. Buckley et al.   Science Translational Medicine

Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats

(2018) Hebatollah E. Eitah et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Casein materials show different digestion patterns using an in vitro gastrointestinal model and different release of glucagon-like peptide-1 by enteroendocrine GLUTag cells

(2018) Yosuke Komatsu et al.   FOOD CHEMISTRY

Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

(2017) Tohru Hira et al.   EUROPEAN JOURNAL OF NUTRITION

Promotion of Glucose Uptake in C2C12 Myotubes by Cereal Flavone Tricin and Its Underlying Molecular Mechanism

(2017) Sohyun Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

(2017) Alice B. Nongonierma et al.   JOURNAL OF FOOD BIOCHEMISTRY

Acute selective bioactivity of grape seed proanthocyanidins on enteroendocrine secretions in the gastrointestinal tract

(2017) Àngela Casanova-Martí et al.   Food & Nutrition Research

Insulinotropic Effects of Whey: Mechanisms of Action, Recent Clinical Trials, and Clinical Applications

(2016) Rachel L. Adams et al.   ANNALS OF NUTRITION AND METABOLISM

Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats

(2016) Ruifeng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The bioactive effects of casein proteins on enteroendocrine cell health, proliferation and incretin hormone secretion

(2016) Anna L. Gillespie et al.   FOOD CHEMISTRY

Simulated GI digestion of dietary protein: Release of new bioactive peptides involved in gut hormone secretion

(2016) Juliette Caron et al.   FOOD RESEARCH INTERNATIONAL

Protein-Enriched Liquid Preloads Varying in Macronutrient Content Modulate Appetite and Appetite-Regulating Hormones in Healthy Adults

(2016) Anestis Dougkas et al.   JOURNAL OF NUTRITION

Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling

(2016) Nazima Bashir et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion

(2016) Masaki Kato et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The effect of encapsulated glutamine on gut peptide secretion in human volunteers

(2016) Claire L. Meek et al.   PEPTIDES

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

(2016) Ramona Pais et al.   PEPTIDES

Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion

(2016) Frank Reimann et al.   Journal of Diabetes Investigation

Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

(2016) Vincenzo Nobile et al.   Food & Nutrition Research

The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans

(2015) Mette J Mandøe et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Comparative effects of intraduodenal whey protein hydrolysate on antropyloroduodenal motility, gut hormones, glycemia, appetite, and energy intake in lean and obese men

(2015) Amy T Hutchison et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fed rats

(2015) Shingo Nakajima et al.   BRITISH JOURNAL OF NUTRITION

Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats

(2015) Tohru Hira et al.   BRITISH JOURNAL OF NUTRITION

GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

(2015) Kristine Færch et al.   DIABETES

An Analysis of Cosecretion and Coexpression of Gut Hormones From Male Rat Proximal and Distal Small Intestine

(2015) Berit Svendsen et al.   ENDOCRINOLOGY

Whey proteins have beneficial effects on intestinal enteroendocrine cells stimulating cell growth and increasing the production and secretion of incretin hormones

(2015) Anna L. Gillespie et al.   FOOD CHEMISTRY

(−)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones

(2015) Won-Young Song et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway

(2015) Masaki Kato et al.   PLoS One

Rice protein hydrolysates stimulate GLP-1 secretion, reduce GLP-1 degradation, and lower the glycemic response in rats

(2015) Yuki Ishikawa et al.   Food & Function

The aglycone of ginsenoside Rg3 enables glucagon-like peptide-1 secretion in enteroendocrine cells and alleviates hyperglycemia in type 2 diabetic mice

(2015) Ki-Suk Kim et al.   Scientific Reports

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans

(2014) Rune E. Kuhre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats

(2014) Gopalan Sriram Prasath et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Grape-Seed Procyanidins Prevent the Cafeteria-Diet-Induced Decrease of Glucagon-Like Peptide-1 Production

(2014) Noemi González-Abuín et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice

(2014) Md. Maroof Alam et al.   LIFE SCIENCES

Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety

(2013) Anita Belza et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation

(2013) Masahito Takikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucose-lowering effect of the DPP-4 inhibitor sitagliptin after glucose and non-glucose macronutrient ingestion in non-diabetic subjects

(2013) L. Ohlsson et al.   DIABETES OBESITY & METABOLISM

Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies

(2013) S. Calanna et al.   DIABETOLOGIA

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

(2013) Eleftheria Diakogiannaki et al.   DIABETOLOGIA

Oral Administration of Corn Zein Hydrolysate Stimulates GLP-1 and GIP Secretion and Improves Glucose Tolerance in Male Normal Rats and Goto-Kakizaki Rats

(2013) Noriyuki Higuchi et al.   ENDOCRINOLOGY

Nutrients related to GLP1 secretory responses

(2013) Asieh Mansour et al.   NUTRITION

High protein intake stimulates postprandial GLP1 and PYY release

(2013) Agatha A. van der Klaauw et al.   Obesity

Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men

(2012) Amy T Ryan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans

(2012) Jihyun Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells

(2012) Manami Oya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice

(2012) Myung Sunny Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

(2011) R.E. Steinert et al.   CLINICAL NUTRITION

Recent advances in pancreatic endocrine and exocrine secretion

(2011) Rashmi Chandra et al.   CURRENT OPINION IN GASTROENTEROLOGY

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

(2011) J. J. Holst et al.   DIABETES CARE

Glutamine Triggers and Potentiates Glucagon-Like Peptide-1 Secretion by Raising Cytosolic Ca2+and cAMP

(2011) Gwen Tolhurst et al.   ENDOCRINOLOGY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glutamine Reduces Postprandial Glycemia and Augments the Glucagon-Like Peptide-1 Response in Type 2 Diabetes Patients

(2011) Dorit Samocha-Bonet et al.   JOURNAL OF NUTRITION

Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract

(2011) Tsuyoshi Goto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

(2011) Thi-Mai Anh Dao et al.   PLoS One

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

(2010) M. A. Nauck et al.   DIABETOLOGIA

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

The Corn Protein, Zein Hydrolysate, Administered into the Ileum Attenuates Hyperglycemia via Its Dual Action on Glucagon-Like Peptide-1 Secretion and Dipeptidyl Peptidase-IV Activity in Rats

(2010) Taisuke Mochida et al.   ENDOCRINOLOGY

Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins

(2010) Maartje C. P. Geraedts et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Selected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716

(2010) Boris Le Nevé et al.   REGULATORY PEPTIDES

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

(2008) Jerry R Greenfield et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus?

(2008) Juris J Meier et al.   Nature clinical practice. Endocrinology & metabolism