An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease

(2021) Hattapark Dejakaisaya et al.   EPILEPSIA

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice

(2020) Na Zhao et al.   NEUROCHEMICAL RESEARCH

Wnt signalling pathway and tau phosphorylation: A comprehensive study on known connections

(2020) Fatemeh Hadi et al.   CELL BIOCHEMISTRY AND FUNCTION

Transplantation of GABAergic Interneuron Progenitor Attenuates Cognitive Deficits of Alzheimer’s Disease Model Mice

(2020) Mei-Hong Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain

(2020) Shaomin Li et al.   JOURNAL OF NEUROCHEMISTRY

Association of Late-Onset Unprovoked Seizures of Unknown Etiology With the Risk of Developing Dementia in Older Veterans

(2020) Ophir Keret et al.   JAMA Neurology

Late-Onset Epilepsy With Unknown Etiology: A Pilot Study on Neuropsychological Profile, Cerebrospinal Fluid Biomarkers, and Quantitative EEG Characteristics

(2020) Elena Nardi Cesarini et al.   Frontiers in Neurology

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

(2020) Samuel S. Harris et al.   NEURON

Internalisation and toxicity of amyloid‐β 1‐42 are influenced by its conformation and assembly state rather than size

(2020) Devkee M. Vadukul et al.   FEBS LETTERS

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

(2020) Vidyasagar Naik Bukke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

(2019) Maria Calvo-Rodriguez et al.   Frontiers in Cellular Neuroscience

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

(2019) Dylan Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single amyloid-beta injection exacerbates 4-aminopyridine-induced seizures and changes synaptic coupling in the hippocampus

(2019) David Alcantara-Gonzalez et al.   HIPPOCAMPUS

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

(2019) Sara Hijazi et al.   MOLECULAR PSYCHIATRY

Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca2+ hyperexcitation

(2019) Julianna L. Sun et al.   NEUROBIOLOGY OF AGING

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

(2018) Benedikt Zott et al.   Annual Review of Neuroscience

Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

(2018) Giovanni Bellomo et al.   CHEMICAL COMMUNICATIONS

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

(2018) Liang Zhang et al.   NEUROBIOLOGY OF DISEASE

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

(2018) Varda Shoshan-Barmatz et al.   PHARMACOLOGICAL RESEARCH

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

(2018) Si-Qiang Ren et al.   Scientific Reports

Soluble Aβ1-40 Peptide Increases Excitatory Neurotransmission and Induces Epileptiform Activity in Hippocampal Neurons

(2018) Magdalena E. Cuevas et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease and late onset epilepsy of unknown origin: two faces of beta amyloid pathology

(2018) Cinzia Costa et al.   NEUROBIOLOGY OF AGING

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

(2017) Sumasri Guntupalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

The dialectic of Hebb and homeostasis

(2017) Gina G. Turrigiano   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later

(2017) Juho Joutsa et al.   JAMA Neurology

Role of Mitochondrial Amyloid-β in Alzheimer's Disease

(2017) John Xi Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease

(2016) Sofya Ziyatdinova et al.   Current Alzheimer Research

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?

(2016) Cinzia Costa et al.   NEUROBIOLOGY OF AGING

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

(2016) Niels R. Reinders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent progress on the role of GABAergic neurotransmission in the pathogenesis of Alzheimer’s disease

(2016) Ghulam Abbas et al.   REVIEWS IN THE NEUROSCIENCES

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity

(2016) James Gilbert et al.   Acta Neuropathologica Communications

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity

(2015) Andreas Müller-Schiffmann et al.   BRAIN

Amyloid-  Impairs Synaptic Inhibition via GABAA Receptor Endocytosis

(2015) D. Ulrich   JOURNAL OF NEUROSCIENCE

Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

(2015) Kathlyn J. Gan et al.   MOLECULAR BIOLOGY OF THE CELL

Study on the inter- and intra-peptide salt-bridge mechanism of Aβ23–28 oligomer interaction with small molecules: QM/MM method

(2015) Subramaniam Boopathi et al.   Molecular BioSystems

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease

(2015) Alessandro Tozzi et al.   NEUROBIOLOGY OF AGING

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons

(2014) B. Wang et al.   JOURNAL OF NEUROSCIENCE

Calcineurin Mediates Synaptic Scaling Via Synaptic Trafficking of Ca2+-Permeable AMPA Receptors

(2014) Seonil Kim et al.   PLOS BIOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ40 modulates GABAAreceptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway

(2013) Xiao-Qin Zhan et al.   JOURNAL OF NEUROCHEMISTRY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Synaptic Scaling Is Mediated by GluA2-Lacking AMPA Receptors in the Embryonic Spinal Cord

(2013) M. A. Garcia-Bereguiain et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

(2013) Elisa M. Ramser et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptic Scaling and Homeostatic Plasticity in the Mouse Visual Cortex In Vivo

(2013) Tara Keck et al.   NEURON

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Incidence of New-Onset Seizures in Mild to Moderate Alzheimer Disease

(2012) Michael C. Irizarry   ARCHIVES OF NEUROLOGY

Seizures in patients with Alzheimer’s disease or vascular dementia: A population-based nested case-control analysis

(2012) Patrick Imfeld et al.   EPILEPSIA

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurologic and motor dysfunctions in APP transgenic mice

(2012) Robert Lalonde et al.   REVIEWS IN THE NEUROSCIENCES

Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

(2011) Angelo Demuro et al.   JOURNAL OF CELL BIOLOGY

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Phosphorylation of AMPA Receptors Is Required for Sensory Deprivation-Induced Homeostatic Synaptic Plasticity

(2011) Anubhuti Goel et al.   PLoS One

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of Mitochondrial Motility by Calcium and Na/K-ATPase at Nodes of Ranvier of Myelinated Nerves

(2010) C. L. Zhang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unraveling Mechanisms of Homeostatic Synaptic Plasticity

(2010) Karine Pozo et al.   NEURON

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils

(2010) Yinon Shafrir et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Oligomers of β-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model

(2009) Renee C. Gaspar et al.   EXPERIMENTAL NEUROLOGY

β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure

(2009) Jorge Parodi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus

(2009) Hey-Kyoung Lee et al.   JOURNAL OF NEUROPHYSIOLOGY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

(2009) D.L. Vogt et al.   NEUROBIOLOGY OF AGING

Epileptic Seizures in AD Patients

(2009) A. J. Larner   NEUROMOLECULAR MEDICINE

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

(2009) Jorge J. Palop et al.   NEUROMOLECULAR MEDICINE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation

(2009) K. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Helix targeting reduces amyloid-  peptide toxicity

(2009) C. Nerelius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Metaplasticity: tuning synapses and networks for plasticity

(2008) Wickliffe C. Abraham   NATURE REVIEWS NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL