Combination of Drugs and Cell Transplantation: More Beneficial Stem Cell-Based Regenerative Therapies Targeting Neurological Disorders

Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01

(2021) Jinghua Piao et al.   Cell Stem Cell

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

(2020) Carlos W. Gantner et al.   Cell Stem Cell

In vivo monitoring of remnant undifferentiated neural cells following human iPS cell‐derived neural stem/progenitor cells transplantation

(2020) Yuji Tanimoto et al.   Stem Cells Translational Medicine

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

(2020) Jeffrey S. Schweitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advantages and Recent Developments of Autologous Cell Therapy for Parkinson’s Disease Patients

(2020) Teresia M. Osborn et al.   Frontiers in Cellular Neuroscience

Zonisamide promotes survival of human‐induced pluripotent stem cell‐derived dopaminergic neurons in the striatum of female rats

(2020) Yoshifumi Miyawaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

(2020) Takahiro Kitahara et al.   Stem Cell Reports

Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

(2020) Shinya Yamanaka   Cell Stem Cell

Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington’s Disease

(2020) Yongwoo Yoon et al.   Frontiers in Neuroscience

Protection induced by estradiol benzoate in the MPP+ rat model of Parkinson's disease is associated with the regulation of the inflammatory cytokine profile in the nigro striatum

(2020) Yoshajandith Aguirre-Vidal et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury

(2019) Suvi Pöyhönen et al.   Frontiers in Physiology

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

(2019) Andrew F. Adler et al.   Cell Reports

Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson’s disease models

(2019) Bin Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Glial cell line–derived neurotrophic factor receptor Rearranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo

(2019) Arun Kumar Mahato et al.   MOVEMENT DISORDERS

A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation

(2018) Yukihiro Matsuyama et al.   JOURNAL OF NEUROSURGERY-SPINE

Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model

(2018) Zeinab Namjoo et al.   METABOLIC BRAIN DISEASE

Drug Repositioning for Effective Prostate Cancer Treatment

(2018) Beste Turanli et al.   Frontiers in Physiology

Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials

(2018) Anke Guhr et al.   Stem Cell Reports

Targeting axonal degeneration and demyelination using combination administration of 17β-estradiol and Schwann cells in the rat model of spinal cord injury

(2018) Zeinab Namjoo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

(2018) Satoshi Nori et al.   Stem Cell Reports

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands

(2017) Deniz Kirik et al.   NEUROBIOLOGY OF DISEASE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

(2017) Yulia A. Sidorova   Frontiers in Pharmacology

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

(2016) Roberto Würth et al.   DRUG DISCOVERY TODAY

Administration of low dose estrogen attenuates persistent inflammation, promotes angiogenesis, and improves locomotor function following chronic spinal cord injury in rats

(2016) Supriti Samantaray et al.   JOURNAL OF NEUROCHEMISTRY

Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway

(2016) Mona Bains et al.   NEUROSCIENCE LETTERS

Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships

(2016) H. H. Ross et al.   PHYSICAL THERAPY

Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors

(2016) Mitsuko Katsukawa et al.   STEM CELLS AND DEVELOPMENT

Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1

(2016) Kaneyasu Nishimura et al.   Stem Cell Reports

Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury

(2015) Ke Li et al.   EXPERIMENTAL NEUROLOGY

X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation

(2015) Bumpei Samata et al.   JOURNAL OF NEUROSCIENCE METHODS

Spatiotemporal PET Imaging of Dynamic Metabolic Changes After Therapeutic Approaches of Induced Pluripotent Stem Cells, Neuronal Stem Cells, and a Chinese Patent Medicine in Stroke

(2015) H. Zhang et al.   JOURNAL OF NUCLEAR MEDICINE

Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice

(2015) Jessica A. Kauhausen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats

(2015) Weihua Chu et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice

(2015) Mélanie Bourque et al.   NEUROENDOCRINOLOGY

Effects of ROCK inhibitor Y27632 and EGFR inhibitor PD168393 on human neural precursors co-cultured with rat auditory brainstem explant

(2015) E. Novozhilova et al.   NEUROSCIENCE

Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration

(2015) Hiroshi Shirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates

(2015) Hiroki Iwai et al.   Stem Cells Translational Medicine

Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors

(2015) Kaneyasu Nishimura et al.   Stem Cells Translational Medicine

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

(2015) Hideki Yagi et al.   PLoS One

Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons

(2014) Tomo Ehashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery

(2013) Daniel Tornero et al.   BRAIN

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

(2013) Maria Sundberg et al.   STEM CELLS

Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell–derived dopaminergic neurons

(2013) Tatsuya Yoshikawa et al.   Frontiers in Cellular Neuroscience

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

(2012) Katsutoshi Sekine et al.   NEURON

Characterizing the Radioresponse of Pluripotent and Multipotent Human Stem Cells

(2012) Mary L. Lan et al.   PLoS One

Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity

(2012) Yoshiomi Kobayashi et al.   PLoS One

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination

(2011) Stephanie D. Boomkamp et al.   GLIA

Axonal Regrowth after Spinal Cord Injury via Chondroitinase and the Tissue Plasminogen Activator (tPA)/Plasmin System

(2011) N. Bukhari et al.   JOURNAL OF NEUROSCIENCE

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Human Pluripotent Stem Cell Therapy for Huntington’s Disease: Technical, Immunological, and Safety Challenges

(2011) Camille Nicoleau et al.   Neurotherapeutics

Roles of 17 -Estradiol Involve Regulation of Reelin Expression and Synaptogenesis in the Dentate Gyrus

(2010) R. A. Bender et al.   CEREBRAL CORTEX

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury

(2010) Masahiko Abematsu et al.   JOURNAL OF CLINICAL INVESTIGATION

17β-Estradiol protects Schwann cells against H2O2-induced cytotoxicity and increases transplanted Schwann cell survival in a cervical hemicontusion spinal cord injury model

(2010) Akkradate Siriphorn et al.   JOURNAL OF NEUROCHEMISTRY

Zonisamide Attenuates MPTP Neurotoxicity in Marmosets

(2010) Mohammed Emamussalehin Choudhury et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice

(2010) Hironori Yokoyama et al.   METABOLIC BRAIN DISEASE

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

(2009) Lachlan H. Thompson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction

(2009) Cinzia Costa et al.   EXPERIMENTAL NEUROLOGY

The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: Clinical relevance

(2009) Patricia K. Sonsalla et al.   EXPERIMENTAL NEUROLOGY

Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells

(2009) Koji Ohira et al.   NATURE NEUROSCIENCE

Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats

(2008) Masahiro Ichikawa et al.   BRAIN RESEARCH