Renin-Angiotensin System in Pathogenesis of Atherosclerosis and Treatment of CVD

Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

(2021) Anastasia V. Poznyak et al.   Frontiers in Pharmacology

Infection and atherosclerosis: TLR-dependent pathways

(2020) Bowei Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

(2020) Tawar Qaradakhi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Signaling Pathways and Key Genes Involved in Regulation of foam Cell Formation in Atherosclerosis

(2020) Anastasia V. Poznyak et al.   Cells

Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules

(2020) Krishnappa Ramya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dietary nitrate attenuated endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for NADPH oxidase

(2020) Rou Peng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The emerging role of cell senescence in atherosclerosis

(2020) Chang-Meng Wu et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Angiotensin II, Hypercholesterolemia, and Vascular Smooth Muscle Cells: A Perfect Trio for Vascular Pathology

(2020) Amanda St. Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NADPH Oxidases and Their Role in Atherosclerosis

(2020) Anastasia V. Poznyak et al.   Biomedicines

Endothelial Dysfunction in Diabetes

(2020) Yusuke Takeda et al.   Biomedicines

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7

(2020) Gabriela M. Silva et al.   Frontiers in Physiology

Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance

(2020) JOSEPH A. BAUER et al.   ANTICANCER RESEARCH

Inflammation in Atherosclerosis—No Longer a Theory

(2020) Peter Libby   CLINICAL CHEMISTRY

Medical Therapy for Heart Failure Caused by Ischemic Heart Disease

(2019) Islam Y. Elgendy et al.   CIRCULATION RESEARCH

The renin angiotensin aldosterone system and its therapeutic targets

(2019) Katrina M. Mirabito Colafella et al.   EXPERIMENTAL EYE RESEARCH

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

(2019) Antonella Fiordelisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?

(2019) Cesar A. Meza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mast Cells as Potential Accelerators of Human Atherosclerosis—From Early to Late Lesions

(2019) Petri T. Kovanen   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Counter-regulatory renin–angiotensin system in cardiovascular disease

(2019) Maria Paz Ocaranza et al.   Nature Reviews Cardiology

Plasminflammation—An Emerging Pathway to Bradykinin Production

(2019) Coen Maas   Frontiers in Immunology

Double-Blind, Randomized, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Eplerenone in Japanese Patients With Chronic Heart Failure (J-EMPHASIS-HF)

(2018) Hiroyuki Tsutsui et al.   CIRCULATION JOURNAL

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

(2017) Meng-Yu Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Oxidative Stress on the Heart and Vasculature

(2017) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease

(2017) Carlos M. Ferrario et al.   PHARMACOLOGICAL RESEARCH

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

(2017) Larissa B. Teixeira et al.   Scientific Reports

Effect of Angiotensin II Type I Receptor Blockade with Valsartan on Carotid Artery Atherosclerosis: A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo (EFFERVESCENT)

(2016) Ronnie Ramadan et al.   AMERICAN HEART JOURNAL

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Early Aldosterone Blockade in Acute Myocardial Infarction

(2016) Farzin Beygui et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease

(2016) Bogusz Trojanowicz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Comparison of angiotensin-(1–7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice

(2015) Jianmin Yang et al.   ATHEROSCLEROSIS

Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches

(2015) Kyoung-Ha Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Angiotensin Converting Enzyme 2 Activator (DIZE) Modulates Metabolic Profiles in Mice, Decreasing Lipogenesis

(2015) Simone Macedo et al.   PROTEIN AND PEPTIDE LETTERS

Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats

(2015) Marilda L.A. De Maria et al.   PROTEIN AND PEPTIDE LETTERS

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

(2015) Rodrigo A. Fraga-Silva et al.   VASCULAR PHARMACOLOGY

Oxidative Stress and Early Atherosclerosis: Novel Antioxidant Treatment

(2014) Dimitris Tousoulis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling

(2014) Clare A. McKinney et al.   CLINICAL SCIENCE

Angiotensin II and Vascular Injury

(2014) Augusto C. Montezano et al.   CURRENT HYPERTENSION REPORTS

ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis

(2014) Yue Hui Zhang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

(2014) Fan Jiang et al.   Nature Reviews Cardiology

Diminazene Attenuates Pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models

(2013) Vinayak Shenoy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Angiotensin-(1–7) Dose-Dependently Inhibits Atherosclerotic Lesion Formation and Enhances Plaque Stability by Targeting Vascular Cells

(2013) Jian Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effect of AVE 0991, nebivolol and doxycycline on inflammatory mediators in an apoE-knockout mouse model of atherosclerosis

(2013) Jacek Jawien et al.   MEDICAL SCIENCE MONITOR

Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism

(2013) Adam P. McGraw et al.   Journal of the American Heart Association

Aliskiren Effect on Plaque Progression in Established Atherosclerosis Using High Resolution 3D MRI (ALPINE): A Double‐Blind Placebo‐Controlled Trial

(2013) Georgeta Mihai et al.   Journal of the American Heart Association

Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis

(2012) Alessandro Durante et al.   CURRENT PHARMACEUTICAL DESIGN

Mineralocorticoid receptor blockade inhibits accelerated atherosclerosis induced by a low sodium diet in apolipoprotein E-deficient mice

(2012) Ayelet Raz-Pasteur et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Measuring and targeting aldosterone and renin in atherosclerosis—A review of clinical data

(2011) Marieke A. Hillaert et al.   AMERICAN HEART JOURNAL

NADPH oxidase-dependent formation of reactive oxygen species contributes to angiotensin II-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells

(2011) Zongpei Jiang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice

(2010) Sonja Tesanovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7)

(2010) Sérgio Henrique S. Santos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pleiotropic Effects of Inhibitors of the RAAS in the Diabetic Population: Above and Beyond Blood Pressure Lowering

(2010) Haisam Ismail et al.   Current Diabetes Reports

Serum Potassium and Clinical Outcomes in the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS)

(2008) Bertram Pitt et al.   CIRCULATION