Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

Cardioprotective Angiotensin-(1–7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 ReceptorNovelty and Significance

(2016) Ségolène Galandrin et al.   HYPERTENSION

Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1–7) and angiotensin-(1–9)

(2015) Francisco Westermeier et al.   PHARMACOLOGICAL RESEARCH

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists

(2015) Geisa A. Santos et al.   Frontiers in Pharmacology

Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor

(2015) G. Michael Felker et al.   JACC-Heart Failure

Relative affinity of angiotensin peptides and novel ligands at AT1and AT2receptors

(2015) Sanja Bosnyak et al.   CLINICAL SCIENCE

Autocrine and Paracrine Function of Angiotensin 1-7 in Tissue Repair During Hypertension

(2014) W. Meng et al.   AMERICAN JOURNAL OF HYPERTENSION

Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins

(2014) Claudio M. Costa-Neto et al.   CLINICAL SCIENCE

Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice

(2014) Ricardo A. Peña Silva et al.   HYPERTENSION

Angiotensin-(1–7)

(2014) Robson Augusto Santos   HYPERTENSION

Effects of the angiotensin-(1-7)/Mas/PI3K/Akt/nitric oxide axis and the possible role of atrial natriuretic peptide in an acute atrial tachycardia canine model

(2014) Jun Zhao et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Pyridostigmine Restores Cardiac Autonomic Balance after Small Myocardial Infarction in Mice

(2014) Marina T. Durand et al.   PLoS One

Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes

(2014) Mariam H. M. Yousif et al.   Journal of Diabetes Research

Discovery and Characterization of Alamandine

(2013) Roberto Queiroga Lautner et al.   CIRCULATION RESEARCH

Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus

(2013) Marilia G.A.G. Pereira et al.   HYPERTENSION

β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury

(2012) Ki-Seok Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

(2012) Guido Boerrigter et al.   Circulation-Heart Failure

Possible mechanism of the cardio-renal protective effects of AVE-0991, a non-peptide Mas-receptor agonist, in diabetic rats

(2012) Kulwinder Singh et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart

(2012) Elisandra Gava et al.   REGULATORY PEPTIDES

Differential  -Arrestin-Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs

(2012) B. Zimmerman et al.   Science Signaling

Acute and chronic angiotensin-(1–7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats

(2011) Gábor Raffai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines

(2011) Guido Boerrigter et al.   Circulation-Heart Failure

Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats

(2011) Asia Rehman et al.   HYPERTENSION

Angiotensin-(1-7) Blockade Attenuates Captopril- or Hydralazine-induced Cardiovascular Protection in Spontaneously Hypertensive Rats Treated With NG-nitro-l-Arginine Methyl Ester

(2011) Ibrahim F Benter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice

(2010) Sonja Tesanovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor

(2010) Silvia Quintão Savergnini et al.   HYPERTENSION

β-Arrestin: A signaling molecule and potential therapeutic target for heart failure

(2010) Nabila Noor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

(2009) Enzo et al.   Frontiers in Bioscience-Landmark

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

(2009) Jihee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The angiotensin-(1–7) receptor agonist AVE0991 is cardioprotective in diabetic rats

(2008) Linda Ebermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction

(2008) Luiza A. Rabelo et al.   Journal of the American Society of Hypertension

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS