Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?

Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOSμ) knockout mice

(2019) Xinmei Zhang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Resveratrol and Its Effects on the Vascular System

(2019) Johannes Breuss et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

(2019) Jay C. Jha et al.   DIABETOLOGIA

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

(2018) Grazia Tamma et al.   Oxidative Medicine and Cellular Longevity

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways

(2018) Shampa Chatterjee   Frontiers in Physiology

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice

(2018) Flávia Rezende et al.   Redox Biology

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased endothelial shear stress improves insulin-stimulated vasodilatation in skeletal muscle

(2018) Lauren K. Walsh et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOURCES OF VASCULAR NITRIC OXIDE AND REACTIVE OXYGEN SPECIES AND THEIR REGULATION

(2018) Jesús Tejero et al.   PHYSIOLOGICAL REVIEWS

Vascular function and endothelin-1: tipping the balance between vasodilation and vasoconstriction

(2017) Steven K. Nishiyama et al.   JOURNAL OF APPLIED PHYSIOLOGY

Crystal structures and atomic model of NADPH oxidase

(2017) Francesca Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Sensors of Blood Flow in Endothelial Cells

(2017) Sara Baratchi et al.   TRENDS IN MOLECULAR MEDICINE

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function

(2017) Abeer M. Mahmoud et al.   Redox Biology

Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH OxidaseHighlights

(2016) Justin D. La Favor et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in ObesityHighlights

(2016) Laura J. Den Hartigh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo

(2016) Na Wu et al.   Cardiovascular Diabetology

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE-/- mice

(2016) E. Di Marco et al.   CLINICAL SCIENCE

Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications

(2016) Rena M. Pollack et al.   DIABETES CARE

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

(2016) George B. Stefano et al.   EUROPEAN JOURNAL OF NUTRITION

Regulation of NADPH oxidases in skeletal muscle

(2016) Leonardo F. Ferreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin attenuates fluctuating glucose-induced endothelial dysfunction through enhancing GTPCH1-mediated eNOS recoupling and inhibiting NADPH oxidase

(2016) Huijie An et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study

(2016) Wilson KC Leung et al.   LIFE SCIENCES

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

(2016) Kiminori Sada et al.   PLoS One

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enzymatic regulation and functional relevance of NOX5

(2015) Feng Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice

(2015) Yet Hoi Hong et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nox2 Mediates Skeletal Muscle Insulin Resistance Induced by a High Fat Diet

(2015) Alvaro Souto Padron de Figueiredo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular function, insulin action, and exercise: an intricate interplay

(2015) Chao Zheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nitric oxide synthase in innate and adaptive immunity: an update

(2015) Christian Bogdan   TRENDS IN IMMUNOLOGY

Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue

(2015) Alexios S. Antonopoulos et al.   DIABETES

Intermittent High Glucose Implements Stress-Induced Senescence in Human Vascular Endothelial Cells: Role of Superoxide Production by NADPH Oxidase

(2015) Morihiko Maeda et al.   PLoS One

Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A Study from South Indian Patients

(2015) Ramu Adela et al.   PLoS One

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Regulation of NADPH Oxidase 5 by Protein Kinase C Isoforms

(2014) Feng Chen et al.   PLoS One

Endothelial NADPH oxidases: which NOX to target in vascular disease?

(2014) Grant R. Drummond et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase

(2014) Beili Shao et al.   Redox Biology

Early onset type 2 diabetes: risk factors, clinical impact and management

(2014) Emma Wilmot et al.   Therapeutic Advances in Chronic Disease

Hyperglycaemia modifies energy metabolism and reactive oxygen species formation in endothelial cells in vitro

(2013) Dorota Dymkowska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Redox Modulation of Endothelial Nitric Oxide Synthase by Glutaredoxin-1 through Reversible Oxidative Post-Translational Modification

(2013) Chun-An Chen et al.   BIOCHEMISTRY

Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice

(2013) Junjie Du et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Nox as a target for diabetic complications

(2013) Yves Gorin et al.   CLINICAL SCIENCE

Resveratrol Protects Vascular Endothelial Cells from High Glucose-Induced Apoptosis through Inhibition of NADPH Oxidase Activation-Driven Oxidative Stress

(2013) Feng Chen et al.   CNS Neuroscience & Therapeutics

Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5'-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes

(2013) Y. Zhao et al.   DIABETES

Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-Related Endothelial Cell Dysfunction

(2013) P. Sukumar et al.   DIABETES

Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II

(2013) Doug-Yoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity

(2013) Cynthia M. Lynch et al.   STROKE

Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia

(2013) Melanie J Sullivan-Gunn et al.   BMC Geriatrics

NOX5 Expression Is Increased in Intramyocardial Blood Vessels and Cardiomyocytes after Acute Myocardial Infarction in Humans

(2012) Nynke E. Hahn et al.   AMERICAN JOURNAL OF PATHOLOGY

Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells

(2012) Clintoria R. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels

(2012) Deepesh Pandey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Quantifying the Effect of Metformin Treatment and Dose on Glycemic Control

(2012) J. A. Hirst et al.   DIABETES CARE

The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

(2012) J. Y. Youn et al.   DIABETOLOGIA

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

(2012) Y Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity, insulin resistance, and skeletal muscle nitric oxide synthase

(2012) Raymond M. Kraus et al.   JOURNAL OF APPLIED PHYSIOLOGY

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

(2012) Nicholas A Graham et al.   Molecular Systems Biology

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

Enhanced endothelin-1 system activity with overweight and obesity

(2011) Brian R. Weil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreased production of neuronal NOS-derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis

(2011) LSA Capettini et al.   BRITISH JOURNAL OF PHARMACOLOGY

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

Endothelial Dysfunction in Diabetes: The role of reparatory mechanisms

(2011) A. Avogaro et al.   DIABETES CARE

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

The beta-isoform of neuronal nitric oxide synthase (nNOS) lacking the PDZ domain is localized at the sarcolemma

(2011) Oliver Baum et al.   FEBS LETTERS

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

Rosiglitazone Revisited

(2010) Steven E. Nissen et al.   ARCHIVES OF INTERNAL MEDICINE

Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition

(2010) Weiguo Chen et al.   BIOCHEMISTRY

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Cardiovascular Disease in Type 2 Diabetes From Population to Man to Mechanisms: The Kelly West Award Lecture 2008

(2010) M. Laakso   DIABETES CARE

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NO synthase: Structures and mechanisms

(2010) Simon Daff   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

(2009) Phyllis Chew et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

(2009) L. Gao et al.   CARDIOVASCULAR RESEARCH

Oxidative Stress and Insulin Resistance: The Coronary Artery Risk Development in Young Adults study

(2009) K. Park et al.   DIABETES CARE

Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose

(2009) Ashraf Taye et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise

(2009) DICK H. J. THIJSSEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

(2008) Qian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

(2008) Francis Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis

(2008) Melanie E. Ivey et al.   ATHEROSCLEROSIS

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

(2008) A. Ceriello et al.   DIABETES

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells

(2008) Alejandra Espinosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY