The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway

(2019) Qi Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Angiotensin-(1-7)-induced Mas receptor activation attenuates atherosclerosis through a nitric oxide-dependent mechanism in apolipoproteinE-KO mice

(2018) Guang Yang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats

(2018) Carmen Castardeli et al.   BIOMEDICINE & PHARMACOTHERAPY

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism

(2018) Evelyn Mendoza-Torres et al.   PHARMACOLOGICAL RESEARCH

Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance

(2018) Mohamed Abdo Rizk et al.   Infection and Drug Resistance

Favorable Vascular Actions of Angiotensin-(1–7) in Human ObesityNovelty and Significance

(2017) Francesca Schinzari et al.   HYPERTENSION

Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity

(2017) Junjiang Chen et al.   Molecular Medicine Reports

Vasodilator Effect of Angiotensin-(1-7) on Vascular Coronary Bed of Rats: Role of Mas, ACE and ACE2

(2017) Patricia Lanza de Moraes et al.   PROTEIN AND PEPTIDE LETTERS

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

(2017) Rhiannon Coulson et al.   Oncotarget

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

(2017) Juanjuan Xu et al.   Frontiers in Physiology

Angiotensin converting enzyme 2 and diminazene

(2016) Elena Velkoska et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Angiotensin (1-7) and Alamandine: Similarities and differences

(2016) Tawar Qaradakhi et al.   PHARMACOLOGICAL RESEARCH

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

(2016) Luiza A. Rabelo et al.   PLoS One

ACE2/Ang-(1–7)/Mas axis stimulates vascular repair-relevant functions of CD34+ cells

(2015) Neha Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of Angiotensin (1-7)-Mediated Signaling Preserves Endothelial Function Through Reducing Oxidative Stress in Diabetes

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina

(2015) G. Foureaux et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue

(2015) Carlos F. Santos et al.   PLoS One

Short-Term Treatment with Diminazene Aceturate Ameliorates the Reduction in Kidney ACE2 Activity in Rats with Subtotal Nephrectomy

(2015) Elena Velkoska et al.   PLoS One

Physical and immunological aspects of exercise in chronic diseases

(2014) Vasso Apostolopoulos et al.   Immunotherapy

Diminazene aceturate (Berenil), a new use for an old compound?

(2014) Shiby Kuriakose et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Angiotensin-(1-7) Augments Endothelium-dependent Relaxations of Porcine Coronary Arteries to Bradykinin by Inhibiting Angiotensin-Converting Enzyme 1

(2014) Gábor Raffai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

(2014) Jie Zhou et al.   Molecular BioSystems

Angiotensin-Converting Enzyme 2 Activation for Treatment of Pulmonary Hypertension

(2013) Florian Veit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diminazene Attenuates Pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models

(2013) Vinayak Shenoy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Discovery and Characterization of Alamandine

(2013) Roberto Queiroga Lautner et al.   CIRCULATION RESEARCH

Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins

(2013) Shiby Kuriakose et al.   Innate Immunity

Endothelial dysfunction : the early predictor of atherosclerosis

(2012) Mashudu Mudau et al.   Cardiovascular Journal of Africa

Diminazene Aceturate (Berenil) Modulates the Host Cellular and Inflammatory Responses to Trypanosoma congolense Infection

(2012) Shiby Kuriakose et al.   PLoS One

Angiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapy

(2011) Lin Zhou et al.   CANCER LETTERS

The Role of Nitric Oxide on Endothelial Function

(2011) Dimitris Tousoulis et al.   Current Vascular Pharmacology

Vascular Endothelial Function and Hypertension: Insights and Directions

(2010) Kodlipet Dharmashankar et al.   CURRENT HYPERTENSION REPORTS

A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit

(2009) Sudarshan Rai et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents

(2008) José A. Hernández Prada et al.   HYPERTENSION