Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease

Pulmonary pathology of COVID-19

(2021) Alain C. Borczuk   CURRENT OPINION IN PULMONARY MEDICINE

The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

(2021) Giovanni Zarrilli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?

(2021) Nicole de Buhr et al.   mBio

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Geographical overlap between alpha-1 antitrypsin deficiency and COVID-19 infection in Italy: casual or causal?

(2020) Andrea Vianello et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Cytokine storm and the prospects for immunotherapy with COVID-19

(2020) Leonard H. Calabrese   CLEVELAND CLINIC JOURNAL OF MEDICINE

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

(2020) Claire S Whyte et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors

(2020) Mathieu Artifoni et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies

(2020) Jennifer L. Sauter et al.   HISTOPATHOLOGY

Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulation: a systematic review and meta-analysis

(2020) Syed Shahzad Hasan et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

The Enigma of Endothelium in COVID-19

(2020) Savneet Kaur et al.   Frontiers in Physiology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Immunopathology of Hyperinflammation in COVID-19

(2020) Joshua N. Gustine et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

(2020) Yun Young Lee et al.   BIOMATERIALS

Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 'Cytokine Storm'

(2020) Sonali Narain et al.   CHEST

Lung Histopathology in COVID-19 as Compared to SARS and H1N1 Influenza: A Systematic Review

(2020) Lida P. Hariri et al.   CHEST

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preventing the development of severe CoVID 19 by modifying immunothrombosis

(2020) Gerwyn Morris et al.   LIFE SCIENCES

Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19

(2020) Paul P. Dobesh et al.   PHARMACOTHERAPY

Bioinspired DNase‐I‐Coated Melanin‐Like Nanospheres for Modulation of Infection‐Associated NETosis Dysregulation

(2020) Hee Ho Park et al.   Advanced Science

Neutrophils and COVID-19: The road so far

(2020) Luiz Henrique Agra Cavalcante-Silva et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

(2020) Jeffrey R Strich et al.   JOURNAL OF INFECTIOUS DISEASES

Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia

(2020) Leo Nicolai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19

(2020) Xiyuan Bai et al.   MEDICAL HYPOTHESES

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

(2020) Léonie A. N. Staats et al.   Cells

The regulatory roles of neutrophils in adaptive immunity

(2019) Yang Li et al.   Cell Communication and Signaling

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

(2018) Omar Elaskalani et al.   Cell Communication and Signaling

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

(2018) Theodora A. M. Claushuis et al.   JOURNAL OF IMMUNOLOGY

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

(2018) Danielle M. Clancy et al.   Cell Reports

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

(2018) Eva Guiducci et al.   Frontiers in Immunology

The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function

(2018) Harriet R. Manley et al.   Frontiers in Immunology

Brg1 inhibits E-cadherin expression in lung epithelial cells and disrupts epithelial integrity

(2017) Ting Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

‘MCC’ protein interacts with E-cadherin and β-catenin strengthening cell–cell adhesion of HCT116 colon cancer cells

(2017) F A Benthani et al.   ONCOGENE

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

(2016) Patricia C. Liaw et al.   BLOOD REVIEWS

Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

(2016) Bárbara Nery Porto et al.   Frontiers in Immunology

Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species

(2015) Halla Björnsdottir et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1–, NF-κB–, and p53-Dependent Pathway

(2009) Tomoko Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE