IL‐33 activates mTORC1 and modulates glycolytic metabolism in CD8 + T cells

The harsh microenvironment in early breast cancer selects for a Warburg phenotype

(2021) Mehdi Damaghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

(2021) Michal A. Stanczak et al.   Nature Communications

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

(2021) Joseph T Clark et al.   eLife

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

(2021) Lanman Xu et al.   Frontiers in Immunology

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

(2020) Tsvetana Petrova et al.   Scientific Reports

Retinoic Acid Modulates Hyperactive T Cell Responses and Protects Vitamin A–Deficient Mice against Persistent Lymphocytic Choriomeningitis Virus Infection

(2020) Yuejin Liang et al.   JOURNAL OF IMMUNOLOGY

Metabolic signaling in T cells

(2020) Justin A. Shyer et al.   CELL RESEARCH

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection from Myocardial Infarction

(2020) Ni Xia et al.   CIRCULATION

Lung megakaryocytes are immune modulatory cells

(2020) Daphne N. Pariser et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars

(2019) Gemma Sangüesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

(2019) Aikaterini Hatzioannou et al.   NATURE IMMUNOLOGY

Role of mTOR in Glucose and Lipid Metabolism

(2018) Zhuo Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease

(2017) Sachiko Furukawa et al.   Scientific Reports

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection

(2017) Panpan Yi et al.   Scientific Reports

The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection

(2016) Vikram Mehraj et al.   AIDS

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response

(2016) Vikram Mehraj et al.   EBioMedicine

Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells

(2016) Violette Gautier et al.   Scientific Reports

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

(2015) D. K. Reichenbach et al.   BLOOD

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

(2015) Yuejin Liang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-infiltrating, interleukin-33-producing effector-memory CD8+T cells in resected hepatocellular carcinoma prolong patient survival

(2015) Stefan M. Brunner et al.   HEPATOLOGY

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

(2015) Claudia Baumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR: A gate to NK cell maturation and activation

(2014) Antoine Marçais et al.   CELL CYCLE

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

(2014) Dong Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+T and NK Cells

(2014) Xin Gao et al.   JOURNAL OF IMMUNOLOGY

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF- -Induced Foxp3 Expression

(2014) S. Ikeda et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

IL-33 Induces Nuocytes and Modulates Liver Injury in Viral Hepatitis

(2013) Y. Liang et al.   JOURNAL OF IMMUNOLOGY

Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation

(2012) Yeon-Sook Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin

(2012) Robert J. Salmond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Full-Length IL-33 Promotes Inflammation but not Th2 Response In Vivo in an ST2-Independent Fashion

(2012) I. G. Luzina et al.   JOURNAL OF IMMUNOLOGY

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

Interleukin-33 and the function of innate lymphoid cells

(2012) Ananda S. Mirchandani et al.   TRENDS IN IMMUNOLOGY

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+T cells

(2011) Qianting Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation

(2011) Jennifer Louten et al.   INTERNATIONAL IMMUNOLOGY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells

(2008) M. D. Smithgall et al.   INTERNATIONAL IMMUNOLOGY