Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

(2020) Pankaj Deo et al.   Nature Microbiology

Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

(2018) Tate Tabtieng et al.   JOURNAL OF VIROLOGY

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis

(2018) Eusondia Arnett et al.   PLoS Pathogens

Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

(2018) Michael D. Stutz et al.   Frontiers in Immunology

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

(2018) Ranja Salvamoser et al.   CELL DEATH AND DIFFERENTIATION

SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells

(2018) Grant R. Campbell et al.   Cell Host & Microbe

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Mycobacterium tuberculosis : Rewiring host cell signaling to promote infection

(2017) Michael D. Stutz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?

(2017) Irina V. Lyadova   MEDIATORS OF INFLAMMATION

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis

(2017) Kaitlyn Schaaf et al.   Scientific Reports

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

(2016) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammatory signaling in human tuberculosis granulomas is spatially organized

(2016) Mohlopheni J Marakalala et al.   NATURE MEDICINE

The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome

(2016) Anthony M. Cadena et al.   mBio

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

(2016) Mary Speir et al.   Nature Microbiology

Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection

(2015) Nelson C. Di Paolo et al.   IMMUNITY

Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis

(2015) Teresa Repasy et al.   MICROBES AND INFECTION

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics

(2014) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phase I Dose-Escalation Study of LCL161, an Oral Inhibitor of Apoptosis Proteins Inhibitor, in Patients With Advanced Solid Tumors

(2014) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo

(2013) Teresa Repasy et al.   PLoS Pathogens

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells

(2012) Robert Blomgran et al.   Cell Host & Microbe

Efferocytosis Is an Innate Antibacterial Mechanism

(2012) Constance J. Martin et al.   Cell Host & Microbe

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2r KO Mice

(2012) S. Tanaka et al.   JOURNAL OF IMMUNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

(2010) Erin McElvania TeKippe et al.   PLoS One

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

(2008) D. A. Steimer et al.   BLOOD

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence

(2008) Huixian Gan et al.   NATURE IMMUNOLOGY