Inhibition of thioredoxin-interacting protein and inflammasome assembly using verapamil mitigates diabetic retinopathy and pancreatic injury

A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Müller cells

(2020) Jingxia Du et al.   EXPERIMENTAL EYE RESEARCH

Morin attenuates STZ-induced diabetic retinopathy in experimental animals

(2020) Bo Jiang et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Oxidative stress-mediated TXNIP loss causes RPE dysfunction

(2019) Min Ji Cho et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy

(2018) Karim M. Tawfik et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardioprotective Mechanisms of Exenatide in Isoprenaline-induced Myocardial Infarction

(2018) Ahmed M. Darwesh et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

(2018) Shyam S. Chaurasia et al.   Scientific Reports

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways

(2018) Feng Zhou et al.   Frontiers in Endocrinology

Blockade of store-operated calcium entry alleviates high glucose-induced neurotoxicity via inhibiting apoptosis in rat neurons

(2016) Zhenkuan Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study

(2016) Yulia Khodneva et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

(2015) Hanitriniaina Rabeony et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cellsviaactivating ROS-TXNIP-NLRP3 inflammasome

(2015) Wei Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Ameliorative effect of acetyl-l-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats

(2014) Lamiaa M. Farghaly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes

(2014) Ahmed M. Abu El-Asrar et al.   MEDIATORS OF INFLAMMATION

Thioredoxin-Interacting Protein Stimulates Its Own Expression via a Positive Feedback Loop

(2014) Junqin Chen et al.   MOLECULAR ENDOCRINOLOGY

Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

(2014) Hongming Miao et al.   Cell Reports

Pentoxifylline decreases glycemia levels and TNF-alpha, iNOS and COX-2 expressions in diabetic rat pancreas

(2014) Francisca Adilfa O Garcia et al.   SpringerPlus

Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury

(2013) M F El-Azab et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

(2013) Guanlan Xu et al.   NATURE MEDICINE

TXNIP shuttling: missing link between oxidative stress and inflammasome activation

(2013) Troy Lane et al.   Frontiers in Physiology

Role of Intravitreal Inflammatory Cytokines and Angiogenic Factors in Proliferative Diabetic Retinopathy

(2012) Jinzi Zhou et al.   CURRENT EYE RESEARCH

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats

(2012) C.R. Lima et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-diabetic and anti-cataract effects of Chromolaena odorata Linn., in streptozotocin-induced diabetic rats

(2012) M. Onkaramurthy et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Alterations to the Blood–Retinal Barrier in Diabetes: Cytokines and Reactive Oxygen Species

(2011) Tiffany Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity

(2011) Mohammed MH Al-Gayyar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines

(2011) Mona F. El-Azab et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein

(2009) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory

(2008) Pooi-See Chan et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS