- Home
- Publications
- Publication Search
- Publication Details
Title
siRNA: Mechanism of action, challenges, and therapeutic approaches
Authors
Keywords
siRNA, Nucleic acids-based therapeutics, Nanocarriers, Delivery systems, Gene knockdown
Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 905, Issue -, Pages 174178
Publisher
Elsevier BV
Online
2021-05-25
DOI
10.1016/j.ejphar.2021.174178
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
- (2020) Sarah Bajan et al. Cells
- Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability
- (2020) Ander Maguregui et al. CHEMBIOCHEM
- Epithelial-mesenchymal transition and membrane microparticles: Potential implications for bronchiolitis obliterans syndrome after lung transplantation
- (2020) Benjamin Renaud-Picard et al. TRANSPLANT IMMUNOLOGY
- Recent Advances of Polycationic siRNA Vectors for Cancer Therapy
- (2020) Raut Bholakant et al. BIOMACROMOLECULES
- siRNA based drug design, quality, delivery and clinical translation
- (2020) Md Abdus Subhan et al. Nanomedicine-Nanotechnology Biology and Medicine
- Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
- (2020) Milad Ashrafizadeh et al. ACS Combinatorial Science
- Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators
- (2020) Milad Ashrafizadeh et al. CELLULAR SIGNALLING
- Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA
- (2019) Maria Abdul Ghafoor Raja et al. Asian Journal of Pharmaceutical Sciences
- siRNA therapeutics: a clinical reality
- (2019) Phei Er Saw et al. Science China-Life Sciences
- Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin
- (2019) Walhan Alshaer et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Efficient nanocarriers of siRNA therapeutics for cancer treatment
- (2019) Md Abdus Subhan et al. Translational Research
- A Novel Method for Controlled Gene Expression via Combined Bleomycin and Plasmid DNA Electrotransfer
- (2019) Sonam Chopra et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function
- (2019) Christina E Weinberg et al. NUCLEIC ACIDS RESEARCH
- Aptamers Chemistry: Chemical Modifications and Conjugation Strategies
- (2019) Fadwa Odeh et al. MOLECULES
- Tivanisiran, a novel siRNA for the treatment of dry eye disease
- (2018) Javier Moreno-Montañés et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model
- (2018) Walhan Alshaer et al. JOURNAL OF CONTROLLED RELEASE
- Connective tissue growth factor (CTGF) from basics to clinics
- (2018) Yasaman Ramazani et al. MATRIX BIOLOGY
- Liposomal Drug Delivery Systems and Anticancer Drugs
- (2018) Temidayo Olusanya et al. MOLECULES
- Respiratory viruses in transplant recipients: more than just a cold. Clinical syndromes and infection prevention principles
- (2017) Salma Abbas et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Antisense oligonucleotides: the next frontier for treatment of neurological disorders
- (2017) Carlo Rinaldi et al. Nature Reviews Neurology
- Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy
- (2017) K. John Pasi et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
- (2017) Kevin Fitzgerald et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
- (2017) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- TFOS DEWS II Definition and Classification Report
- (2017) Jennifer P. Craig et al. Ocular Surface
- Chemical and structural modifications of RNAi therapeutics
- (2016) Sook Hee Ku et al. ADVANCED DRUG DELIVERY REVIEWS
- Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines
- (2016) Jinho Park et al. ADVANCED DRUG DELIVERY REVIEWS
- Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics
- (2016) Soo Hyeon Lee et al. ADVANCED DRUG DELIVERY REVIEWS
- Delivery strategies and potential targets for siRNA in major cancer types
- (2016) So Jin Lee et al. ADVANCED DRUG DELIVERY REVIEWS
- Precise and efficient siRNA design: a key point in competent gene silencing
- (2016) E Fakhr et al. CANCER GENE THERAPY
- ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients
- (2016) Jens Gottlieb et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors
- (2016) Adeel Masood Butt et al. MOLECULAR PHARMACEUTICS
- Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial
- (2016) Jake Dunning et al. PLOS MEDICINE
- siRNAmod: A database of experimentally validated chemically modified siRNAs
- (2016) Showkat Ahmad Dar et al. Scientific Reports
- Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms
- (2015) Laura Novellasdemunt et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Who discovered messenger RNA?
- (2015) Matthew Cobb CURRENT BIOLOGY
- Phase 2, open-label extension (OLE) study of revusiran, an investigational RNAi therapeutic for the treatment of patients with transthyretin cardiac amyloidosis
- (2015) Julian D Gillmore et al. Orphanet Journal of Rare Diseases
- RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients
- (2015) Talia Golan et al. Oncotarget
- siRNA Versus miRNA as Therapeutics for Gene Silencing
- (2015) Jenny K W Lam et al. Molecular Therapy-Nucleic Acids
- First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors
- (2014) Beate Schultheis et al. JOURNAL OF CLINICAL ONCOLOGY
- Current issues of RNAi therapeutics delivery and development
- (2014) D. Haussecker JOURNAL OF CONTROLLED RELEASE
- Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment
- (2014) Manju Saraswathy et al. Materials Today
- Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
- (2014) Y Aye et al. ONCOGENE
- Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
- (2014) J. E. Zuckerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Getting Syk: spleen tyrosine kinase as a therapeutic target
- (2014) Robert L. Geahlen TRENDS IN PHARMACOLOGICAL SCIENCES
- 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
- (2014) Sherry Y. Wu et al. Nature Communications
- Complement disorders and hemolytic uremic syndrome
- (2013) Catherine Joseph et al. CURRENT OPINION IN PEDIATRICS
- First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement
- (2013) Josep Tabernero et al. Cancer Discovery
- Alpha-1 antitrypsin deficiency: a commonly overlooked cause of lung disease
- (2012) S. K. Brode et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- RNA-Based Therapeutics: Current Progress and Future Prospects
- (2012) John C. Burnett et al. CHEMISTRY & BIOLOGY
- Bronchiolitis Obliterans Syndrome
- (2011) Jamie L. Todd et al. CHEST
- Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
- (2011) Claudia Scholz et al. JOURNAL OF CONTROLLED RELEASE
- Unknown
- (2011) Gerd Gauglitz et al. MOLECULAR MEDICINE
- Hepatitis B prevention, diagnosis, treatment and care: a review
- (2011) E. J. Aspinall et al. OCCUPATIONAL MEDICINE-OXFORD
- Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients
- (2011) S. Weigt et al. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
- (2010) Jun Fang et al. ADVANCED DRUG DELIVERY REVIEWS
- RNAi-Based Treatment for Neovascular Age-Related Macular Degeneration by Sirna-027
- (2010) Peter K. Kaiser et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema
- (2010) Toshinori Yoshida et al. NATURE MEDICINE
- Lipid-based systemic delivery of siRNA
- (2009) Yu-Cheng Tseng et al. ADVANCED DRUG DELIVERY REVIEWS
- Origins and Mechanisms of miRNAs and siRNAs
- (2009) Richard W. Carthew et al. CELL
- Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
- (2009) Pia R. Kamstrup JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder
- (2009) Sancy A Leachman et al. MOLECULAR THERAPY
- Familial adenomatous polyposis
- (2009) Elizabeth Half et al. Orphanet Journal of Rare Diseases
- Age-Related Macular Degeneration
- (2008) Rama D. Jager et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search