2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Tumour angiogenesis regulation by the miR-200 family

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Src activation by β-adrenoreceptors is a key switch for tumour metastasis

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First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions

(2012) Xianbin Yang et al.   ACS Chemical Biology

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity

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Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer

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siRNA-optimized Modifications for Enhanced In Vivo Activity

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Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer

(2011) P. E. Vivas-Mejia et al.   CLINICAL CANCER RESEARCH

Making sense of cancer genomic data

(2011) Lynda Chin et al.   GENES & DEVELOPMENT

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

(2011) Norliana Khairuddin et al.   IMMUNOLOGY AND CELL BIOLOGY

Pharmacological Characterization of Chemically Synthesized Monomeric phi29 pRNA Nanoparticles for Systemic Delivery

(2011) Sherine Abdelmawla et al.   MOLECULAR THERAPY

Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs

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SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer

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Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models

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Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Quantitative evaluation of siRNA delivery in vivo

(2010) Y. Pei et al.   RNA

Use of Data-Biased Random Walks on Graphs for the Retrieval of Context-Specific Networks from Genomic Data

(2010) Kakajan Komurov et al.   PLoS Computational Biology

Lipidic Systems for In Vivo siRNA Delivery

(2009) Sherry Y. Wu et al.   AAPS Journal

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Stem-Loop RT-PCR Quantification of siRNAs In Vitro and In Vivo

(2009) Angie Cheng et al.   OLIGONUCLEOTIDES

Selective Protection of Nuclease-Sensitive Sites in siRNA Prolongs Silencing Effect

(2009) Anton A. Volkov et al.   OLIGONUCLEOTIDES

Ago2 Immunoprecipitation Identifies Predicted MicroRNAs in Human Embryonic Stem Cells and Neural Precursors

(2009) Loyal A. Goff et al.   PLoS One

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE