Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study

(2021) Hany M. Dabbous et al.   ARCHIVES OF VIROLOGY

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

(2021) Gordon J. Lockbaum et al.   Viruses-Basel

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

In silico Analysis Revealed Potential Anti-SARS-CoV-2 Main Protease Activity by the Zonulin Inhibitor Larazotide Acetate

(2021) Simone Di Micco et al.   Frontiers in Chemistry

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

(2021) Jerzy Osipiuk et al.   Nature Communications

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

(2021) Zinuo Chen et al.   Cell and Bioscience

A Comprehensive Review of Viral Characteristics, Transmission, Pathophysiology, Immune Response, and Management of SARS-CoV-2 and COVID-19 as a Basis for Controlling the Pandemic

(2021) Chris R. Triggle et al.   Frontiers in Immunology

Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

(2021) Chun-Hui Zhang et al.   ACS Central Science

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study

(2021) Krishnaprasad Baby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors

(2021) Naoya Kitamura et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery

(2020) Ariane Sternberg et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

(2020) Joseph M. Grimes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus

(2020) Kuldeep Dhama et al.   Travel Medicine and Infectious Disease

Modeling the Onset of Symptoms of COVID-19

(2020) Joseph R. Larsen et al.   Frontiers in Public Health

Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

(2020) Augusto Di Castelnuovo et al.   European Journal of Internal Medicine

High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment

(2020) Biswajit Naik et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cysteine focused covalent inhibitors against the main protease of SARS-CoV-2

(2020) Archi Sundar Paul et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

(2020) Wioletta Rut et al.   Science Advances

Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease

(2020) Qingxin Li et al.   Microorganisms

Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches

(2020) Magda Gioia et al.   BIOCHEMICAL PHARMACOLOGY

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

(2020) Yixin Xie et al.   Frontiers in Molecular Biosciences

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

(2019) Elma Mons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach

(2019) Carmine Ostacolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lipophilic organic pollutants induce changes in phospholipid and membrane protein composition leading to Vero cell morphological change

(2014) Ting T. Liao et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

(2014) Shyam Krishnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol–alkyne addition

(2013) Stefanie Sommer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells

(2008) Claudriana Locatelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY