Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review

(2020) Hua-Li Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis

(2019) Vitthal B Makane et al.   Future Medicinal Chemistry

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review

(2019) M. Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazole scaffolds in anti-tuberculosis drug discovery

(2019) Suparna S. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel Schiff bases and azol-β-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity

(2019) Yıldız Uygun Cebeci et al.   BIOORGANIC CHEMISTRY

Design, synthesis and in silico study of pyridine based 1,3,4-oxadiazole embedded hydrazinecarbothioamide derivatives as potent anti-tubercular agent

(2019) Ajay N. Ambhore et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

(2019) Wan-Yin Fang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review

(2019) Yu-Mei Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological activities and docking studies of piperazine incorporated 1, 3, 4-oxadiazole derivatives

(2019) Shipra Bhati et al.   JOURNAL OF MOLECULAR STRUCTURE

Chalcone derivatives and their antibacterial activities: Current development

(2019) Man Xu et al.   BIOORGANIC CHEMISTRY

Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships

(2019) Man Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key Review

(2018) K. P. Rakesh et al.   Anti-Cancer Agents in Medicinal Chemistry

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action

(2018) Rudolf Vosátka et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety

(2018) T.G. Shruthi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmaceutical significance of azepane based motifs for drug discovery: A critical review

(2018) Gao-Feng Zha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

(2018) Chuang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

S -substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents

(2017) Galina Karabanovich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzisoxazole: a privileged scaffold for medicinal chemistry

(2017) K. P. Rakesh et al.   MedChemComm

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

(2017) John N. Alumasa et al.   ACS Infectious Diseases

Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis

(2016) Julie V. Early et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity

(2016) Vijaya Rao Pidugu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents

(2016) N.C. Desai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitubercular activity of new 1,3,4-oxadiazoles bearing pyridyl and thiazolyl scaffolds

(2016) Sambhaji T. Dhumal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of a novel class of quinoline–oxadiazole hybrids as anti-tuberculosis agents

(2016) Puneet P. Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives

(2016) Nagabhushana Nayak et al.   CHINESE CHEMICAL LETTERS

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis

(2016) Guilherme Felipe dos Santos Fernandes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

(2016) Galina Karabanovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and characterization of a fluoro substituted novel pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds and their biological applications

(2016) Sharad C. Karad et al.   RSC Advances

Novel benzimidazole–oxadiazole hybrid molecules as promising antimicrobial agents

(2016) N. Shruthi et al.   RSC Advances

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

(2015) Subramanyam J. Tantry et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel 1,3,4-oxadiazole motifs bearing a quinoline nucleus: synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and cytotoxic activities

(2015) Gaurav G. Ladani et al.   NEW JOURNAL OF CHEMISTRY

Tetrazole regioisomers in the development of nitro group-containing antitubercular agents

(2015) Galina Karabanovich et al.   MedChemComm

DprE1 - from the Discovery to the Promising Tuberculosis Drug Target

(2014) Katarina Miku.sova et al.   CURRENT PHARMACEUTICAL DESIGN

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

(2014) Galina Karabanovich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bedaquiline for the treatment of resistant tuberculosis: Promises and pitfalls

(2014) Ashish Kumar Kakkar et al.   TUBERCULOSIS

Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity

(2013) Shuai Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New 2-benzylsulfanyl-nicotinic acid based 1,3,4-oxadiazoles: Their synthesis and biological evaluation

(2013) Navin B. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents

(2013) Rajesh A. Rane et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles

(2013) N.C. Desai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-piperazine derivatives and evaluation of their in vivo anticonvulsant activity

(2013) Kikkeri P. Harish et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of New (Pyrazol-3-yl)-1,3,4-oxadiazole Derivatives by Unexpected Aromatization During Oxidative Cyclization of 4,5-Dihydro-1H-pyrazole-3-carbohydrazones and Their Biological Activities

(2013) K. Jagadeesh Prathap et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Green approach towards synthesis of substituted pyrazole-1,4-dihydro,9-oxa,1,2,6,8-tetrazacyclopentano[b]naphthalene-5-one derivatives as antimycobacterial agents

(2013) Santosh S. Chobe et al.   MEDICINAL CHEMISTRY RESEARCH

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

(2013) P. Horrocks et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent

(2012) Rajesh A. Rane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: A natural product coupled approach to semicarbazones for antiepileptic activity

(2012) Harish Rajak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles

(2012) Abdulrahman I. Almansour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles

(2012) Dinneswara Reddy Guda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent

(2012) Juan Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antituberculosis Drug Research: A Critical Overview

(2012) Beena et al.   MEDICINAL RESEARCH REVIEWS

The structure–antituberculosis activity relationships study in a series of 5-aryl-2-thio-1,3,4-oxadiazole derivatives

(2011) Fliur Macaev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents

(2011) Mohamed Jawed Ahsan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel antitubercular 1,5-dimethyl-2-phenyl-4-([5-(arylamino)-1,3,4-oxadiazol-2-yl]methylamino)-1,2-dihydro-3H-pyrazol-3-one analogues

(2011) Mohamed Jawed Ahsan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current Status and Research Strategies in Tuberculosis Drug Development

(2011) Lynn G. Dover et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ethionamide Boosters: Synthesis, Biological Activity, and Structure−Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors

(2011) Marion Flipo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors

(2011) Marion Flipo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships for Amide-, Carbamate-, And Urea-Linked Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2011) Adrian Blaser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

(2011) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

(2011) Karen G. Anthony et al.   PLoS One

Exploring Drug Target Flexibility Usingin SituClick Chemistry: Application to a Mycobacterial Transcriptional Regulator

(2010) Nicolas Willand et al.   ACS Chemical Biology

Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents

(2010) G.V. Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Utilization of the Suzuki Coupling to Enhance the Antituberculosis Activity of Aryloxazoles

(2010) Marvin J. Miller et al.   HETEROCYCLES

Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems – A novel class of potential antibacterial, antifungal and antitubercular agents

(2009) B.P. Mallikarjuna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives

(2008) Suvarna G. Kini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs

(2008) Subash Velaparthi et al.   JOURNAL OF MEDICINAL CHEMISTRY

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: A novel class of potential antibacterial and antitubercular agents

(2007) S.D. Joshi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY