DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway

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Dual‐Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1

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Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

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Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells

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Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition

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MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension

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Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability

(2020) Zijie Zhang et al.   NATURE GENETICS

Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease

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p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart

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The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA

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Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus

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The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

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Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis

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Dipeptidyl Peptidase 4 Inhibitors and the Risk of Bullous Pemphigoid Among Patients With Type 2 Diabetes

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Wwp2 maintains cartilage homeostasis through regulation of Adamts5

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Mad1 destabilizes p53 by preventing PML from sequestering MDM2

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Factors influencing osteogenic differentiation of human aortic valve interstitial cells

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Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

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MicroRNA-21 deficiency attenuated atherogenesis and decreased macrophage infiltration by targeting Dusp-8

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Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

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Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology

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Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves

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Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition

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Dual-specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice through TAK1 Suppression

(2018) Ping Ye et al.   HEPATOLOGY

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

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Calcific aortic valve stenosis: hard disease in the heart

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Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

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Altered MicroRNA Expression Is Responsible for the Pro‐Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves

(2017) Rui Song et al.   Journal of the American Heart Association

Management strategies and future challenges for aortic valve disease

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MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

(2016) Duk-Hwa Kwon et al.   Nature Communications

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

(2016) Yan-Xiao Ji et al.   Nature Communications

Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148

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COX2 Inhibition Reduces Aortic Valve Calcification In VivoSignificance

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

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Effective Gene Delivery to Valvular Interstitial Cells Using Adeno-Associated Virus Serotypes 2 and 3

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Conventional therapies fail to target inflammation and immune imbalance in subjects with stable coronary artery disease: A system-based approach

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The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

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Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease

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Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

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Role of Circulating Osteogenic Progenitor Cells in Calcific Aortic Stenosis

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Lipid Lowering on Progression of Mild to Moderate Aortic Stenosis: Meta-analysis of the Randomized Placebo-Controlled Clinical Trials on 2344 Patients

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