Mineralocorticoid receptor actions in cardiovascular development and disease

The Role of the Mineralocorticoid Receptor and Mineralocorticoid Receptor–Directed Therapies in Heart Failure

(2021) Morag J Young et al.   ENDOCRINOLOGY

MiRNA ‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

(2020) Ankita Garg et al.   EUROPEAN JOURNAL OF HEART FAILURE

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

(2020) Jennifer Maning et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identifying new cellular mechanisms of mineralocorticoid receptor activation in the heart

(2020) Morag J. Young et al.   JOURNAL OF HUMAN HYPERTENSION

Circadian rhythms and the molecular clock in cardiovascular biology and disease

(2019) Sandra Crnko et al.   Nature Reviews Cardiology

MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity

(2019) Clara Lefranc et al.   HYPERTENSION

Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling

(2019) Elizabeth K Fletcher et al.   JOURNAL OF ENDOCRINOLOGY

Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner

(2019) M. Elizabeth Moss et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mineralocorticoid Receptor and Endothelial Dysfunction in Hypertension

(2019) Jessica L. Faulkner et al.   CURRENT HYPERTENSION REPORTS

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

(2019) Peter J. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2

(2019) Alessandro Cannavo et al.   Frontiers in Pharmacology

Spironolactone suppresses aldosterone-induced Kv1.5 expression by attenuating mineralocorticoid receptor-Nox1/2/4-mediated ROS generation in neonatal rat atrial myocytes

(2019) Guihua Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to Disease

(2019) Alessandra Feraco et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes

(2018) Riko Koyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

(2018) Marc D. Ruben et al.   Science Translational Medicine

Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling

(2017) Maniselvan Kuppusamy et al.   ENDOCRINOLOGY

Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice

(2017) Elizabeth K Fletcher et al.   ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: informing cell-type-specific roles

(2017) Timothy J Cole et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Coregulators as mediators of mineralocorticoid receptor signalling diversity

(2017) Peter J Fuller et al.   JOURNAL OF ENDOCRINOLOGY

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice

(2017) Laura A. Bienvenu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mineralocorticoid Receptor Blockade Improves Insulin Sensitivity in the Rat Heart and a Possible Molecular Mechanism

(2016) Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages

(2016) Jimmy Z. Shen et al.   ENDOCRINOLOGY

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial InfarctionNovelty and Significance

(2016) Alexandre Gueret et al.   HYPERTENSION

Mineralocorticoid regulation of cell function: the role of rapid signalling and gene transcription pathways

(2016) Gregory S Y Ong et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice

(2015) Brian Bostick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2

(2015) Naveen K. Somanna et al.   CELLULAR SIGNALLING

Cardiomyocyte Mineralocorticoid Receptor Activation Impairs Acute Cardiac Functional Recovery After Ischemic InsultNovelty and Significance

(2015) Laura A. Bienvenu et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females

(2015) Guanghong Jia et al.   HYPERTENSION

GEMIN4 functions as a coregulator of the mineralocorticoid receptor

(2015) J. Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Atrial Natriuretic Peptide Locally Counteracts the Deleterious Effects of Cardiomyocyte Mineralocorticoid Receptor Activation

(2014) Hitoshi Nakagawa et al.   Circulation-Heart Failure

CCL2-Dependent Macrophage Recruitment Is Critical for Mineralocorticoid Receptor-Mediated Cardiac Fibrosis, Inflammation, and Blood Pressure Responses in Male Mice

(2014) J.Z. Shen et al.   ENDOCRINOLOGY

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

The role of the circadian clock in rheumatoid arthritis

(2013) Julie E Gibbs et al.   ARTHRITIS RESEARCH & THERAPY

Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling

(2012) Claudia Grossmann et al.   CHEMISTRY & BIOLOGY

Biphasic Action of Aldosterone on Akt Signaling in Cardiomyocytes

(2012) T. Nagoshi et al.   HORMONE AND METABOLIC RESEARCH

Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis

(2012) Amanda J. Rickard et al.   HYPERTENSION

Aldosterone Inhibits Antifibrotic Factors in Mouse Hypertensive Heart

(2012) Feriel Azibani et al.   HYPERTENSION

Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System

(2012) Celine Latouche et al.   HYPERTENSION

Cardiomyocyte Mineralocorticoid Receptor Function Post Myocardial Infarction

(2012) Daniela Fraccarollo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

(2011) Daniela Fraccarollo et al.   CIRCULATION

Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency

(2010) Damien Le Menuet et al.   CARDIOVASCULAR RESEARCH

The Mineralocorticoid Receptor Is a Constitutive Nuclear Factor in Cardiomyocytes due to Hyperactive Nuclear Localization Signals

(2010) Iván Hernández-Díaz et al.   ENDOCRINOLOGY

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure

(2010) Katharina Fischer et al.   MOLECULAR ENDOCRINOLOGY

Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display

(2010) Jun Yang et al.   MOLECULAR ENDOCRINOLOGY

Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins

(2009) Ana María Gómez et al.   CIRCULATION

Short Communication: Ischemia/Reperfusion Tolerance Is Time-of-Day–Dependent

(2009) David J. Durgan et al.   CIRCULATION RESEARCH

Role of the T-Type Calcium Channel CaV3.2 in the Chronotropic Action of Corticosteroids in Isolated Rat Ventricular Myocytes

(2009) Andrés Maturana et al.   ENDOCRINOLOGY

Glucocorticoids Activate Cardiac Mineralocorticoid Receptors During Experimental Myocardial Infarction

(2009) Anastasia S. Mihailidou et al.   HYPERTENSION

L-type Ca2+ current in ventricular cardiomyocytes

(2009) Jean-Pierre Benitah et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mineralocorticoid receptor and its coregulators

(2009) Jun Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The hsp90-FKBP52 Complex Links the Mineralocorticoid Receptor to Motor Proteins and Persists Bound to the Receptor in Early Nuclear Events

(2009) M. D. Galigniana et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart

(2008) Peter Wilson et al.   CLINICAL SCIENCE

A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function

(2008) John M. C. Connell et al.   ENDOCRINE REVIEWS

Corticosteroids and Redox Potential Modulate Spontaneous Contractions in Isolated Rat Ventricular Cardiomyocytes

(2008) Michel F. Rossier et al.   HYPERTENSION