MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity

Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production

(2018) Daigo Sawaki et al.   CIRCULATION

Modulation of Vascular Reactivity by Perivascular Adipose Tissue (PVAT)

(2018) Claudia Agabiti-Rosei et al.   CURRENT HYPERTENSION REPORTS

Smooth Muscle Cell–Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With AgingNovelty and Significance

(2018) Seung Kyum Kim et al.   HYPERTENSION

Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

(2018) Aurelie Nguyen Dinh Cat et al.   Scientific Reports

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

(2018) Jaime Ibarrola et al.   Scientific Reports

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

(2016) Bastien Vergoni et al.   DIABETES

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

(2016) Aurelie Nguyen Dinh Cat et al.   DIABETES

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

(2016) Laura M. Pérez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of Mitochondrial Complex IV in Age-Dependent Obesity

(2016) Ines Soro-Arnaiz et al.   Cell Reports

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

(2015) S. B. Bender et al.   HYPERTENSION

Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through NoxNovelty and Significance

(2015) Karla Bianca Neves et al.   HYPERTENSION

Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 SynthaseNovelty and Significance

(2015) Riccardo Urbanet et al.   HYPERTENSION

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects

(2013) R. Garg et al.   DIABETES OBESITY & METABOLISM

The sirtuin family’s role in aging and age-associated pathologies

(2013) Jessica A. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium

(2013) M.B. Nolly et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

(2013) Maria S. Fernández-Alfonso et al.   International Journal of Endocrinology

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Extrarenal effects of aldosterone

(2012) Aurelie Nguyen Dinh Cat et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways

(2012) Ana M. Briones et al.   HYPERTENSION

“Is obesity linked to aging?”

(2011) Irene P. Tzanetakou et al.   AGEING RESEARCH REVIEWS

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

(2011) Chunhua Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Primary Aldosteronism and Metabolic Syndrome

(2011) F. Fallo et al.   HORMONE AND METABOLIC RESEARCH

Adipocyte-Derived Factors Regulate Vascular Smooth Muscle Cells Through Mineralocorticoid and Glucocorticoid Receptors

(2011) Aurelie Nguyen Dinh Cat et al.   HYPERTENSION

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice

(2010) Juha Ketonen et al.   CIRCULATION JOURNAL

Aldosterone/Mineralocorticoid Receptor Stimulation Induces Cellular Senescence in the Kidney

(2010) Yu-Yan Fan et al.   ENDOCRINOLOGY

Hypoxia enhances the relaxing influence of perivascular adipose tissue in isolated mice aorta

(2010) Nele Maenhaut et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

(2010) Alexander W. Krug et al.   HYPERTENSION

Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice

(2009) Ayumu Hirata et al.   CARDIOVASCULAR RESEARCH

Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

(2009) Adam S. Greenstein et al.   CIRCULATION

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Mineralocorticoid receptor activation in obesity hypertension

(2009) Miki Nagase et al.   HYPERTENSION RESEARCH

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

(2009) Cíntia dos Santos Costa et al.   OBESITY SURGERY

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Aldosterone Inhibits Insulin-Induced Glucose Uptake by Degradation of Insulin Receptor Substrate (IRS) 1 and IRS2 via a Reactive Oxygen Species-Mediated Pathway in 3T3-L1 Adipocytes

(2008) Tsutomu Wada et al.   ENDOCRINOLOGY

Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women

(2008) S B Pedersen et al.   INTERNATIONAL JOURNAL OF OBESITY

Primary aldosteronism: cardiovascular, renal and metabolic implications

(2008) Gian-Paolo Rossi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial nuclear receptors and transcription factors: Who's minding the cell?

(2007) Junghee Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH