Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity

DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance

(2015) Euan A. Stronach et al.   NEOPLASIA

miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non-Small Cell Lung Cancer

(2013) J. Cai et al.   CANCER RESEARCH

Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells

(2013) Zhennan Gu et al.   CARCINOGENESIS

Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells

(2013) Hsing-Yu Chen et al.   EMBO Molecular Medicine

Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury

(2013) Zhen Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific activation of AKT protects cells from death induced by glucose deprivation

(2013) M Gao et al.   ONCOGENE

Fyn Kinases Play a Critical Role in Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation or Amyloid-β Peptide Treatment

(2012) Cai-Ping Du et al.   CNS Neuroscience & Therapeutics

Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease

(2012) Mateusz Kurzawski et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Diacylglycerol Kinase δ Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2)

(2012) Tracy M. Crotty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHLPP1 Gene Deletion Protects the Brain from Ischemic Injury

(2012) Bo Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kainic Acid-Induced Seizures Modulate Akt (SER473) Phosphorylation in the Hippocampus of Dopamine D2 Receptor Knockout Mice

(2012) Mark Dunleavy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

(2011) E E Vincent et al.   BRITISH JOURNAL OF CANCER

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Mechanical Regulation of Glycogen Synthase Kinase 3β (GSK3β) in Mesenchymal Stem Cells Is Dependent on Akt Protein Serine 473 Phosphorylation via mTORC2 Protein

(2011) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote pkcδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model

(2011) Hariharan Saminathan et al.   NEUROTOXICOLOGY

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus

(2010) Travis C. Jackson et al.   JOURNAL OF NEUROCHEMISTRY

Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis

(2010) Meng Qiao et al.   MOLECULAR CELL

Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6

(2009) Mei Hua Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications

(2009) Heping Yang et al.   HEPATOLOGY

Depletion of Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatases 1 and 2 by Bcr-Abl Promotes Chronic Myelogenous Leukemia Cell Proliferation through Continuous Phosphorylation of Akt Isoforms

(2009) Isao Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common Polymorphism in the Phosphatase PHLPP2 Results in Reduced Regulation of Akt and Protein Kinase C

(2009) John Brognard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

(2008) J Liu et al.   ONCOGENE

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes

(2008) Ling Wang et al.   TOXICOLOGICAL SCIENCES