Evidence of cancer-promoting roles for AMPK and related kinases

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

(2015) M Momcilovic et al.   BRITISH JOURNAL OF CANCER

The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator

(2015) Brandon Faubert et al.   CANCER LETTERS

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

(2015) Carlos T. Pineda et al.   CELL

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer

(2015) Petra Popovics et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer

(2015) Roland Hubaux et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

(2015) Emily Jane Gallagher et al.   PHYSIOLOGICAL REVIEWS

Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation

(2015) Evrim Gurpinar et al.   TRENDS IN CELL BIOLOGY

Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators

(2015) Takafumi Miyamoto et al.   Cell Reports

AMPK: a cellular energy sensor primarily regulated by AMP

(2014) Graeme J. Gowans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

(2014) Manami Kodaka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

(2014) Ming Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

Risk Prediction for Late-Stage Ovarian Cancer by Meta-analysis of 1525 Patient Samples

(2014) Markus Riester et al.   JNCI-Journal of the National Cancer Institute

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

(2014) Jonathan M. Goodwin et al.   MOLECULAR CELL

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis

(2014) Nathan Benaich et al.   Cell Reports

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

(2013) Sourav Banerjee et al.   BIOCHEMICAL JOURNAL

Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes

(2013) Bárbara Mesquita et al.   BREAST CANCER RESEARCH AND TREATMENT

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1

(2013) Rachel E. Bell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Normal and cancer cell metabolism: lymphocytes and lymphoma

(2012) Brian J. Altman et al.   FEBS Journal

Inactivation of MARK4, an AMP-activated Protein Kinase (AMPK)-related Kinase, Leads to Insulin Hypersensitivity and Resistance to Diet-induced Obesity

(2012) Chao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity

(2012) Hayley M. O’Neill et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

(2012) Lidan Liu et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

(2012) H B Nguyen et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Wnt/Myc interactions in intestinal cancer: Partners in crime

(2011) Kevin Myant et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma

(2011) T. Namiki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells

(2010) Zchong-Zcho Wu et al.   BIOCHEMICAL PHARMACOLOGY

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis

(2010) J. K. Lennerz et al.   MOLECULAR AND CELLULAR BIOLOGY

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

The regulation and function of mammalian AMPK-related kinases

(2009) N. J. Bright et al.   Acta Physiologica

Snf1-related protein kinases (SnRKs) act within an intricate network that links metabolic and stress signalling in plants

(2009) Nigel G. Halford et al.   BIOCHEMICAL JOURNAL

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

(2009) Nicolas Humbert et al.   EMBO JOURNAL

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Phosphatidylinositol Ether Lipid Analogues Induce AMP-Activated Protein Kinase Dependent Death in LKB1-Mutant Non Small Cell Lung Cancer Cells

(2008) R. M. Memmott et al.   CANCER RESEARCH

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci

(2008) Katsuya Tsuchihara et al.   CANCER SCIENCE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL