Article
Environmental Sciences
Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi, Dejun Huang
Summary: The study revealed that Cd-induced promoter hypermethylation of RASSF1A and DAPK1, decreasing their expression and leading to higher level of cell proliferation. Furthermore, Cd at low concentrations could influence DNA methylation, which may serve as the proliferative mechanism of Cd.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Cell Biology
Yuliya S. Krasikova, Olga I. Lavrik, Nadejda I. Rechkunova
Summary: This review summarizes the structure of the XPA protein and its interactions with other proteins during nucleotide excision repair, as well as the regulation of XPA protein activity and expression and the network of post-translational modifications. It also discusses data that does not align with the current hypothesis about the functioning of the XPA protein.
Article
Multidisciplinary Sciences
Mihyun Kim, Hyun-Suk Kim, Areetha D'Souza, Kaitlyn Gallagher, Eunwoo Jeong, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A. Tainer, Jung-Eun Yeo, Walter J. Chazin, Orlando D. Scharer
Summary: The XPA and RPA proteins play essential roles in the assembly of the preincision complex in the nucleotide excision repair pathway. Mutations in the interaction sites of XPA and RPA inhibit the physical interaction and reduce the NER activity. The interaction between XPA-N and RPA32C is important for the initial association of XPA with NER complexes, while the interaction between XPA DBD and RPA70AB is needed for structural organization of the complex to license the dual incision reaction. The shape of the NER bubble is not colinear as previously thought, but rather the unwound DNA assumes a U-shape with the junctions localized in close proximity. The interaction between XPA and RPA70 is key for the organization of the NER preincision complex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yarui Zhang, Guomin Ou, Zhujing Ye, Zhou Zhou, Qianlin Cao, Mengting Li, Jingdong Wang, Jianping Cao, Hongying Yang
Summary: This study identified that RPRM regulates ATM protein levels and affects DNA repair and cellular radiosensitivity. The mechanism involves RPRM nuclear translocation through phosphorylation at serine 98 and the participation of IPO11. Additionally, RPRM overexpression sensitizes cells to genotoxic agents, while RPRM deficiency increases resistance to radiation-induced damage.
Article
Biochemistry & Molecular Biology
Maria J. J. Solares, Deborah F. F. Kelly
Summary: Genetic mutations in tumor suppressor genes can lead to cancer, with mutations in p53 potentially exacerbating toxic effects and impeding DNA interactions, emphasizing the need for new studies to assist in redesigning targeted therapies based on protein structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Stephanie McKenna, Lucia Garcia-Gutierrez
Summary: Melanoma treatment is therapeutically challenging, with resistance mechanisms to MAPK inhibition, where abnormal RASSF1A gene expression could be associated with therapy resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yang Chen, Yin Zhao, Xiaojing Yang, Xianyue Ren, Shengyan Huang, Sha Gong, Xirong Tan, Junyan Li, Shiwei He, Yingqin Li, Xiaohong Hong, Qian Li, Cong Ding, Xueliang Fang, Jun Ma, Na Liu
Summary: This study demonstrates that the deubiquitinase USP44 enhances the radiosensitivity of nasopharyngeal carcinoma cells by promoting the degradation of Ku80. Low expression of USP44 is associated with poor prognosis and tumor relapse in clinical settings.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jiajia Zhang, Zhenzhen Yan, Yukun Wang, Yaguang Wang, Xin Guo, Ju Jing, Xiangnan Dong, Shasha Dong, Xiuhua Liu, Xiaochun Yu, Chen Wu
Summary: The study examined mutations in the TP53 binding protein 1 (53BP1) gene in various human cancers, revealing that these mutations may disrupt the DNA damage repair function of 53BP1 and impact genomic stability.
Article
Cell Biology
Sha Song, Xianjue Ma
Summary: The study identifies a crucial E2 enzyme called Bruce that acts as a bridge between the cell surface signal and the activation of the Hippo pathway in Drosophila. Bruce works in synergy with the E3 ubiquitin ligase POSH to regulate growth and ubiquitination-mediated Ex degradation, thereby affecting Hippo pathway.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Yarong Dai, Maosheng Cheng, Siyan Zhang, Rongsong Ling, Jieqi Wen, Yifan Cheng, Boxuan Huang, Jinrong Li, Caifeng Dai, Shiqing Mao, Shuibin Lin, Huangxuan Shen, Yizhou Jiang
Summary: The study reveals the crucial role of m(6)A RNA modification in regulating injury repair, particularly in promoting cell proliferation and migration for faster corneal injury repair. The identification of stem cell regulatory factors AHNAK and DDIT4 as m(6)A targets provides novel insights for clinical therapy of corneal diseases.
STEM CELLS INTERNATIONAL
(2021)
Article
Cell Biology
Ying Zhang, Wei Wei, Changying Li, Siyuan Yan, Shanshan Wang, Shudong Xiao, Chenchen He, Jing Li, Zhi Qi, Benyi Li, Kuo Yang, Changlin Li
Summary: The study shows that idarubicin (IDA) can overcome resistance to abiraterone and enzalutamide in prostate cancer cells by inhibiting the expression of DNA repair protein XPA.
CELL DEATH & DISEASE
(2022)
Article
Biology
Changyu Zhu, Yadira M. Soto-Feliciano, John P. Morris, Chun-Hao Huang, Richard P. Koche, Yu-jui Ho, Ana Banito, Chun-Wei Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A. Armstrong, C. David Allis, Darjus F. Tschaharganeh, Scott W. Lowe
Summary: Mutations in genes involved in chromatin modification and remodeling are frequently observed in human cancers. This study shows that MLL3 co-activates the Cdkn2a tumor suppressor gene by linking chromatin remodeling to tumor suppression. Disruption of Kmt2c and Myc overexpression cooperate to promote hepatocellular carcinoma development in mice.
Article
Cell Biology
Jun-Long Zhao, Yu-Chen Ye, Chun-Chen Gao, Liang Wang, Kai-Xi Ren, Ru Jiang, Si-Jun Hu, Shi-Qian Liang, Jian Bai, Jia-Long Liang, Peng-Fei Ma, Yi-Yang Hu, Ben-Chang Li, Yong-Zhan Nie, Yan Chen, Xiao-Fei Li, Wei Zhang, Hua Han, Hong-Yan Qin
Summary: Activated Notch signaling regulates lactate metabolism and is involved in MDSC differentiation and TAM maturation. By reducing lactate levels, Notch signaling inhibits G-MDSC differentiation and enhances TAM maturation.
Article
Biochemistry & Molecular Biology
Stavroula Tsaridou, Georgia Velimezi, Frances Willenbrock, Maria Chatzifrangkeskou, Waheba Elsayed, Andreas Panagopoulos, Dimitris Karamitros, Vassilis Gorgoulis, Zoi Lygerou, Vassilis Roukos, Eric O'Neill, Dafni Eleftheria Pefani
Summary: This study identified a novel role for the tumor suppressor RASSF1A at rDNA break sites, providing mechanistic insight into how the DNA damage response is organized in a chromatin context and further evidence for how silencing of the RASSF1A tumor suppressor contributes to genome instability.
Article
Oncology
Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal, LaCreis R. Kidd
Article
Oncology
M. Lee Schmidt, Katharine R. Hobbing, Howard Donninger, Geoffrey J. Clark
Article
Biochemical Research Methods
Liqing He, Xiaoli Wei, Xipeng Ma, Xinmin Yin, Ming Song, Howard Donninger, Kavitha Yaddanapud, Craig J. McClain, Xiang Zhang
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2019)
Letter
Respiratory System
Desmond Harrell Stewart, Katherine Hobbing, M. Lee Schmidt, Howard Donninger, Geoffrey J. Clark
JOURNAL OF THORACIC DISEASE
(2019)
Article
Multidisciplinary Sciences
Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Jacquelyn Powers, Emilia M. Pinto, Thibaut Barnoud, Jessica C. Leung, Tetyana Martynyuk, Andrew Kossenkov, Aaron H. Philips, Heena Desai, Ryan Hausler, Gregory Kelly, Anh N. Le, Marilyn M. Li, Suzanne P. MacFarland, Louise C. Pyle, Kristin Zelley, Katherine L. Nathanson, Susan M. Domchek, Thomas P. Slavin, Jeffrey N. Weitzel, Jill E. Stopfer, Judy E. Garber, Vijai Joseph, Kenneth Offit, Jill S. Dolinsky, Stephanie Gutierrez, Kelly McGoldrick, Fergus J. Couch, Brooke Levin, Morris C. Edelman, Carolyn Fein Levy, Sheri L. Spunt, Richard W. Kriwacki, Gerard P. Zambetti, Raul C. Ribeiro, Maureen E. Murphy, Kara N. Maxwell
Review
Immunology
Chi Li, Howard Donninger, John Eaton, Kavitha Yaddanapudi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Thibaut Barnoud, Jessica C. Leung, Julia I-Ju Leu, Subhasree Basu, Adi Narayana, Reddy Poli, Joshua L. D. Parris, Alexandra Indeglia, Tetyana Martynyuk, Madeline Good, Keerthana Gnanapradeepan, Emilio Sanseviero, Rebecca Moeller, Hsin-Yao Tang, Joel Cassel, Andrew V. Kossenkov, Qin Liu, David W. Speicher, Dmitry I. Gabrilovich, Joseph M. Salvino, Donna L. George, Maureen E. Murphy
Article
Oncology
Desmond R. Harrell Stewart, M. Lee Schmidt, Howard Donninger, Geoffrey J. Clark
Review
Biochemistry & Molecular Biology
Thibaut Barnoud, Alexandra Indeglia, Maureen E. Murphy
Summary: The TP53 gene remains the most frequently mutated gene in cancer, driving intense research efforts to understand its role in tumor suppression. The journey towards understanding p53 function has been complex and challenging, leading to paradigm shifts and emerging challenges for future research. This review provides a valuable historical reference for those interested in p53 and highlights the importance of flexibility in the face of established paradigms.
Article
Oncology
Joshua L. D. Parris, Thibaut Barnoud, Julia I. -Ju Leu, Jessica C. Leung, Weili Ma, Nicole A. Kirven, Adi Naryana Reddy Poli, Andrew V. Kossenkov, Qin Liu, Joseph M. Salvino, Donna L. George, Ashani T. Weeraratna, Qing Chen, Maureen E. Murphy
Summary: This study showed that astrocytes enhance the sensitivity of melanoma tumors to MEK inhibitors, while ID3 acts as a mediator of adaptive resistance. By combining HSP70 inhibitors with MEK inhibitors, the survival rate of mice with NRAS-mutant melanoma was significantly improved.
CANCER RESEARCH COMMUNICATIONS
(2021)
Article
Biology
Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce Lee, William J. Quinn, Che-Pei Kung, Rexford Ahima, Joseph A. Baur, Kathryn E. Wellen, Qin Liu, Zachary T. Schug, Donna L. George, Maureen E. Murphy
Review
Cell Biology
Thibaut Barnoud, Joshua L. D. Parris, Maureen E. Murphy
JOURNAL OF MOLECULAR CELL BIOLOGY
(2019)
Article
Health Care Sciences & Services
Serena Yeung, Francesca Rinaldo, Jeffrey Jopling, Bingbin Liu, Rishab Mehra, N. Lance Downing, Michelle Guo, Gabriel M. Bianconi, Alexandre Alahi, Julia Lee, Brandi Campbell, Kayla Deru, William Beninati, Li Fei-Fei, Arnold Milstein
NPJ DIGITAL MEDICINE
(2019)