Cell cycle proliferation decisions: the impact of single cell analyses

Irreversible APC Cdh1 Inactivation Underlies the Point of No Return for Cell-Cycle Entry

(2016) Steven D. Cappell et al.   CELL

Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit

(2016) Jacob Stewart-Ornstein et al.   Cell Reports

Single-cell analysis of transcription kinetics across the cell cycle

(2016) Samuel O Skinner et al.   eLife

A Dynamical Framework for the All-or-None G1/S Transition

(2016) Alexis R. Barr et al.   Cell Systems

Variation is function: Are single cell differences functionally important?

(2015) Hannah Dueck et al.   BIOESSAYS

Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

(2015) John J. Tyson et al.   BMC BIOLOGY

Sequential replication-coupled destruction at G1/S ensures genome stability

(2015) Kate E. Coleman et al.   GENES & DEVELOPMENT

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Simultaneous measurement of passage through the restriction point and MCM loading in single cells

(2015) T. W. Håland et al.   NUCLEIC ACIDS RESEARCH

Multiple mechanisms determine the order of APC/C substrate degradation in mitosis

(2014) Dan Lu et al.   JOURNAL OF CELL BIOLOGY

PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length

(2014) Nana Naetar et al.   MOLECULAR CELL

A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation

(2014) Michael C. Weis et al.   PLoS One

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control

(2014) Peng Dong et al.   Nature Communications

Modelling mammalian cellular quiescence

(2014) G. Yao   Interface Focus

A novel cell-cycle-indicator, mVenus-p27K−, identifies quiescent cells and visualizes G0–G1 transition

(2014) Toshihiko Oki et al.   Scientific Reports

Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues

(2014) Norman Zielke et al.   Cell Reports

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

(2013) Sabrina L. Spencer et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Start and the restriction point

(2013) Amy Johnson et al.   CURRENT OPINION IN CELL BIOLOGY

Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset

(2013) Xi Yuan et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

(2013) Ran Kafri et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity

(2013) S. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase Portraits of the Proliferation-Quiescence Decision

(2013) T. Zhang   Science Signaling

Regulating DNA Replication in Bacteria

(2013) K. Skarstad et al.   Cold Spring Harbor Perspectives in Biology

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

(2012) Jérémy Huard et al.   FEBS Journal

The abbreviated pluripotent cell cycle

(2012) Kristina Kapinas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quiescent fibroblasts are protected from proteasome inhibition–mediated toxicity

(2012) Aster Legesse-Miller et al.   MOLECULAR BIOLOGY OF THE CELL

A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency

(2012) Diana Coronado et al.   Stem Cell Research

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Modeling the Cell Cycle: Why Do Certain Circuits Oscillate?

(2011) James E. Ferrell et al.   CELL

Origin licensing and p53 status regulate Cdk2 activity during G1

(2011) Kathleen R. Nevis et al.   CELL CYCLE

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

Universal patterns of stem cell fate in cycling adult tissues

(2011) A. M. Klein et al.   DEVELOPMENT

Stem cell self-renewal in intestinal crypt

(2011) Benjamin D. Simons et al.   EXPERIMENTAL CELL RESEARCH

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload

(2011) Marjorie A. Kuipers et al.   JOURNAL OF CELL BIOLOGY

Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

(2011) Karl A. Merrick et al.   MOLECULAR CELL

How APC/C–Cdc20 changes its substrate specificity in mitosis

(2011) Daisuke Izawa et al.   NATURE CELL BIOLOGY

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Essence of Quiescence

(2011) H. A. Coller   SCIENCE

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells

(2010) Cara L. Lunn et al.   CELL CYCLE

Measurement of single-cell dynamics

(2010) David G. Spiller et al.   NATURE

Quantitative Time-Lapse Fluorescence Microscopy in Single Cells

(2009) Dale Muzzey et al.   Annual Review of Cell and Developmental Biology

Eukaryotic DNA replication control: Lock and load, then fire

(2009) Dirk Remus et al.   CURRENT OPINION IN CELL BIOLOGY

Illuminating cell-cycle progression in the developing zebrafish embryo

(2009) M. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Temporal Organization of the Cell Cycle

(2008) John J. Tyson et al.   CURRENT BIOLOGY

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS

A role for Myc in facilitating transcription activation by E2F1

(2008) J Y Leung et al.   ONCOGENE

Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1

(2008) L. Sang et al.   SCIENCE